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• W2093585687 abstract "TRK oncogenes are observed in a consistent fraction of papillary thyroid carcinoma (PTC); they arise from the fusion of the 3' terminal sequences of the NTRK1/NGF receptor gene with 5' terminal sequences of various activating genes, such as TPM3, TPR and TFG. TRK oncoproteins display constitutive tyrosine-kinase activity, leading to in vitro and in vivo transformation. In this review studies performed during the last 20 years will be summarized. The following topics will be illustrated: (a) frequency of TRK oncogenes and correlation with radiation and tumor histopathological features; (b) molecular mechanisms underlying NTRK1 oncogenic rearrangements; (c) molecular and biochemical characterization of TRK oncoproteins, and their mechanism of action; (d) role of activating sequences in the activation of TRK oncoproteins." @default.
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• W2093585687 date "2010-05-01" @default.
• W2093585687 modified "2023-09-25" @default.
• W2093585687 title "Rearrangements of NTRK1 gene in papillary thyroid carcinoma" @default.
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• W2093585687 doi "https://doi.org/10.1016/j.mce.2009.10.009" @default.
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