FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2093586136> ?p ?o ?g. }

• W2093586136 endingPage "224" @default.
• W2093586136 startingPage "213" @default.
• W2093586136 abstract "In most mesenchymal tissues a subcompartment of multipotent progenitor cells is responsible for the maintenance and repair of the tissue following trauma. With increasing age, the ability of tissues to repair themselves is diminished, which may be due to reduced functional capacity of the progenitor cells. The purpose of this study was to investigate the effect of aging on rat mesenchymal progenitor cells. Mesenchymal progenitor cells were isolated from Wistar rats aged 3, 7, 12 and 56 weeks. Viability, capacity for differentiation and cellular aging were examined. Cells from the oldest group accumulated raised levels of oxidized proteins and lipids and showed decreased levels of antioxidative enzyme activity. This was reflected in decreased fibroblast colony-forming unit (CFU-f) numbers, increased levels of apoptosis and reduced proliferation and potential for differentiation. These data suggest that the reduced ability to maintain mesenchymal tissue homeostasis in aged mammals is not purely due to a decline in progenitor cells numbers but also to a loss of progenitor functionality due to the accumulation of oxidative damage, which may in turn be a causative factor in a number of age-related pathologies such as arthritis, tendinosis and osteoporosis." @default.
• W2093586136 created "2016-06-24" @default.
• W2093586136 creator A5002866332 @default.
• W2093586136 creator A5065423789 @default.
• W2093586136 date "2006-06-01" @default.
• W2093586136 modified "2023-10-18" @default.
• W2093586136 title "Age-related impairment of mesenchymal progenitor cell function" @default.
• W2093586136 cites W128190313 @default.
• W2093586136 cites W1508246447 @default.
• W2093586136 cites W1584738578 @default.
• W2093586136 cites W1590457525 @default.
• W2093586136 cites W1590867470 @default.
• W2093586136 cites W1966012405 @default.
• W2093586136 cites W1966763839 @default.
• W2093586136 cites W1967322347 @default.
• W2093586136 cites W1968814931 @default.
• W2093586136 cites W1969144177 @default.
• W2093586136 cites W1970181548 @default.
• W2093586136 cites W1970191803 @default.
• W2093586136 cites W1981043866 @default.
• W2093586136 cites W1982555416 @default.
• W2093586136 cites W1984190184 @default.
• W2093586136 cites W1984995716 @default.
• W2093586136 cites W1987957447 @default.
• W2093586136 cites W1989016250 @default.
• W2093586136 cites W1992935708 @default.
• W2093586136 cites W1996803044 @default.
• W2093586136 cites W1998461585 @default.
• W2093586136 cites W2000330544 @default.
• W2093586136 cites W2001478552 @default.
• W2093586136 cites W2001627351 @default.
• W2093586136 cites W2002320509 @default.
• W2093586136 cites W2003928089 @default.
• W2093586136 cites W2006847107 @default.
• W2093586136 cites W2007194140 @default.
• W2093586136 cites W2007638378 @default.
• W2093586136 cites W2013875783 @default.
• W2093586136 cites W2018686812 @default.
• W2093586136 cites W2019668164 @default.
• W2093586136 cites W2021134616 @default.
• W2093586136 cites W2024209230 @default.
• W2093586136 cites W2028419771 @default.
• W2093586136 cites W2028922560 @default.
• W2093586136 cites W2031349710 @default.
• W2093586136 cites W2031812736 @default.
• W2093586136 cites W2034390132 @default.
• W2093586136 cites W2035176325 @default.
• W2093586136 cites W2035368716 @default.
• W2093586136 cites W2036011375 @default.
• W2093586136 cites W2036676765 @default.
• W2093586136 cites W2040400696 @default.
• W2093586136 cites W2041632213 @default.
• W2093586136 cites W2042041984 @default.
• W2093586136 cites W2042297829 @default.
• W2093586136 cites W2045456080 @default.
• W2093586136 cites W2046873552 @default.
• W2093586136 cites W2051478899 @default.
• W2093586136 cites W2053247751 @default.
• W2093586136 cites W2059485125 @default.
• W2093586136 cites W2062822095 @default.
• W2093586136 cites W2067256604 @default.
• W2093586136 cites W2068409711 @default.
• W2093586136 cites W2069444350 @default.
• W2093586136 cites W2072807932 @default.
• W2093586136 cites W2073192310 @default.
• W2093586136 cites W2074687883 @default.
• W2093586136 cites W2080205733 @default.
• W2093586136 cites W2087030052 @default.
• W2093586136 cites W2089750948 @default.
• W2093586136 cites W2090102540 @default.
• W2093586136 cites W2091526175 @default.
• W2093586136 cites W2093355627 @default.
• W2093586136 cites W2095666785 @default.
• W2093586136 cites W2097462469 @default.
• W2093586136 cites W2098036900 @default.
• W2093586136 cites W2104908670 @default.
• W2093586136 cites W2109477623 @default.
• W2093586136 cites W2109794889 @default.
• W2093586136 cites W2118622683 @default.
• W2093586136 cites W2119739306 @default.
• W2093586136 cites W2122888633 @default.
• W2093586136 cites W2128118061 @default.
• W2093586136 cites W2129778797 @default.
• W2093586136 cites W2134465683 @default.
• W2093586136 cites W2157191016 @default.
• W2093586136 cites W2159999899 @default.
• W2093586136 cites W2169268511 @default.
• W2093586136 cites W2315512556 @default.
• W2093586136 cites W4240284563 @default.
• W2093586136 cites W4247351964 @default.
• W2093586136 cites W4251969693 @default.
• W2093586136 doi "https://doi.org/10.1111/j.1474-9726.2006.00213.x" @default.
• W2093586136 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16842494" @default.
• W2093586136 hasPublicationYear "2006" @default.
• W2093586136 type Work @default.
• W2093586136 sameAs 2093586136 @default.
• W2093586136 citedByCount "195" @default.
• W2093586136 countsByYear W20935861362012 @default.

• next