FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2093594136> ?p ?o ?g. }

• W2093594136 abstract "You have accessJournal of UrologyUrodynamics/Incontinence/Female Urology: Basic Research II1 Apr 2015MP12-17 PROTECTIVE EFFECT OF A RHO-KINASE INHIBITOR ON CHRONIC ISCHEMIA-RELATED BLADDER DYSFUNCTION Hidenori Akaihata, Masanori Nomiya, Nobuhiro Haga, Nobuhiro Kushida, Kei Ishibashi, Ken Aikawa, Osamu Yamaguchi, and Yoshiyuki Kojima Hidenori AkaihataHidenori Akaihata More articles by this author , Masanori NomiyaMasanori Nomiya More articles by this author , Nobuhiro HagaNobuhiro Haga More articles by this author , Nobuhiro KushidaNobuhiro Kushida More articles by this author , Kei IshibashiKei Ishibashi More articles by this author , Ken AikawaKen Aikawa More articles by this author , Osamu YamaguchiOsamu Yamaguchi More articles by this author , and Yoshiyuki KojimaYoshiyuki Kojima More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2015.02.792AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Recent studies have suggested that aging-associated changes in pelvic vasculature such as atherosclerosis eventually result in chronic bladder ischemia, which may play a key role in the development of lower urinary tract symptoms. Currently, it has been shown that the RhoA/Rho-kinase (ROK) pathway is substantially involved in the pathogenesis of atherosclerosis. On the other hand, there are many studies reporting that alteration of the RhoA/ROK pathway is at least partly involved in bladder overactivity. However, it has not been established whether inhibition of the RhoA/ROK pathway affects chronic ischemia-related bladder dysfunction. The aim of study is to investigate the effect of fasudil, a ROK inhibitor, on chronic ischemia-related bladder dysfunction by using a rat model of chronic bladder ischemia. METHODS Adult Sprague-Dawley male rats (16 weeks old) were divided into control, arterial endothelial injury (AI), and AI with fasudil treatment (AI/Fa) groups. The AI group underwent balloon endothelial injury of bilateral iliac arteries and received a 2 percent cholesterol diet for 8 weeks to induce chronic bladder ischemia. The AI/Fa group was given fasudil (30 mg/kg/day) orally once daily after arterial endothelial injury and received a 2 percent cholesterol diet for 8 weeks. The control group received a regular diet for 8 weeks. After cystometrogram (CMG) recording, the bladders and common iliac arteries were harvested for pharmacological and histological examinations. RESULTS The mean arterial wall thickness of the common iliac arteries was significantly greater in the AI group than in the control group. The collagen ratio in the muscle layer in the AI group was significantly increased as compared with the control group. In the organ bath study, contractile responses of muscle strips to various stimuli were significantly less in the AI group than in the control group. In the CMG, the micturition interval was significantly shorter in the AI group than in the control group. In the AI/Fa group, arterial wall thickening was significantly suppressed compared with the AI group. The collagen ratio in the muscle layer was significantly decreased in AI/Fa group as compared with AI group. Furthermore, significant improvements were seen in muscle strip contractility and cystometric parameters in the AI/Fa group compared with the AI group. CONCLUSIONS The present results suggest that chronic treatment with fasudil may prevent neointimal formation and chronic ischemia-related bladder dysfunction, resulting in improvement of bladder hyperactivity. © 2015 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 193Issue 4SApril 2015Page: e134 Advertisement Copyright & Permissions© 2015 by American Urological Association Education and Research, Inc.Metrics Author Information Hidenori Akaihata More articles by this author Masanori Nomiya More articles by this author Nobuhiro Haga More articles by this author Nobuhiro Kushida More articles by this author Kei Ishibashi More articles by this author Ken Aikawa More articles by this author Osamu Yamaguchi More articles by this author Yoshiyuki Kojima More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ..." @default.
• W2093594136 created "2016-06-24" @default.
• W2093594136 creator A5032118890 @default.
• W2093594136 creator A5033408219 @default.
• W2093594136 creator A5042828451 @default.
• W2093594136 creator A5052084624 @default.
• W2093594136 creator A5053487648 @default.
• W2093594136 creator A5076149190 @default.
• W2093594136 creator A5081989746 @default.
• W2093594136 creator A5085526247 @default.
• W2093594136 date "2015-04-01" @default.
• W2093594136 modified "2023-10-01" @default.
• W2093594136 title "MP12-17 PROTECTIVE EFFECT OF A RHO-KINASE INHIBITOR ON CHRONIC ISCHEMIA-RELATED BLADDER DYSFUNCTION" @default.
• W2093594136 doi "https://doi.org/10.1016/j.juro.2015.02.792" @default.
• W2093594136 hasPublicationYear "2015" @default.
• W2093594136 type Work @default.
• W2093594136 sameAs 2093594136 @default.
• W2093594136 citedByCount "0" @default.
• W2093594136 crossrefType "journal-article" @default.
• W2093594136 hasAuthorship W2093594136A5032118890 @default.
• W2093594136 hasAuthorship W2093594136A5033408219 @default.
• W2093594136 hasAuthorship W2093594136A5042828451 @default.
• W2093594136 hasAuthorship W2093594136A5052084624 @default.
• W2093594136 hasAuthorship W2093594136A5053487648 @default.
• W2093594136 hasAuthorship W2093594136A5076149190 @default.
• W2093594136 hasAuthorship W2093594136A5081989746 @default.
• W2093594136 hasAuthorship W2093594136A5085526247 @default.
• W2093594136 hasConcept C126322002 @default.
• W2093594136 hasConcept C184235292 @default.
• W2093594136 hasConcept C201800478 @default.
• W2093594136 hasConcept C2776048814 @default.
• W2093594136 hasConcept C2777093181 @default.
• W2093594136 hasConcept C2778609687 @default.
• W2093594136 hasConcept C2780942790 @default.
• W2093594136 hasConcept C541997718 @default.
• W2093594136 hasConcept C62478195 @default.
• W2093594136 hasConcept C71924100 @default.
• W2093594136 hasConcept C77411442 @default.
• W2093594136 hasConcept C86803240 @default.
• W2093594136 hasConcept C95444343 @default.
• W2093594136 hasConceptScore W2093594136C126322002 @default.
• W2093594136 hasConceptScore W2093594136C184235292 @default.
• W2093594136 hasConceptScore W2093594136C201800478 @default.
• W2093594136 hasConceptScore W2093594136C2776048814 @default.
• W2093594136 hasConceptScore W2093594136C2777093181 @default.
• W2093594136 hasConceptScore W2093594136C2778609687 @default.
• W2093594136 hasConceptScore W2093594136C2780942790 @default.
• W2093594136 hasConceptScore W2093594136C541997718 @default.
• W2093594136 hasConceptScore W2093594136C62478195 @default.
• W2093594136 hasConceptScore W2093594136C71924100 @default.
• W2093594136 hasConceptScore W2093594136C77411442 @default.
• W2093594136 hasConceptScore W2093594136C86803240 @default.
• W2093594136 hasConceptScore W2093594136C95444343 @default.
• W2093594136 hasIssue "4S" @default.
• W2093594136 hasLocation W20935941361 @default.
• W2093594136 hasOpenAccess W2093594136 @default.
• W2093594136 hasPrimaryLocation W20935941361 @default.
• W2093594136 hasRelatedWork W1750949018 @default.
• W2093594136 hasRelatedWork W1988653710 @default.
• W2093594136 hasRelatedWork W2020985989 @default.
• W2093594136 hasRelatedWork W2041492288 @default.
• W2093594136 hasRelatedWork W2096917683 @default.
• W2093594136 hasRelatedWork W2126320858 @default.
• W2093594136 hasRelatedWork W3016757020 @default.
• W2093594136 hasRelatedWork W3147902037 @default.
• W2093594136 hasRelatedWork W3206158417 @default.
• W2093594136 hasRelatedWork W50052632 @default.
• W2093594136 hasVolume "193" @default.
• W2093594136 isParatext "false" @default.
• W2093594136 isRetracted "false" @default.
• W2093594136 magId "2093594136" @default.
• W2093594136 workType "article" @default.