Matches in SemOpenAlex for { <https://semopenalex.org/work/W2093622405> ?p ?o ?g. }
- W2093622405 endingPage "11" @default.
- W2093622405 startingPage "1" @default.
- W2093622405 abstract "Pancreatic cancer is one of the most fatal malignancies with increasing incidence and high mortality. Possibilities for early diagnosis are limited and there is currently no efficient therapy. Molecular markers that have been introduced into diagnosis and treatment of other solid tumors remain unreciprocated in this disease. Recent discoveries have shown that certain microRNAs (miRNAs) take part in fundamental molecular processes associated with pancreatic cancer initiation and progression including cell cycle, DNA repair, apoptosis, invasivity, and metastasis. The mechanism involves both positive and negative regulation of expression of protooncogenes and tumor suppressor genes. Various miRNAs are expressed at different levels among normal pancreatic tissue, chronic pancreatitis, and pancreatic cancer and may therefore serve as a tool to differentiate chronic pancreatitis from early stages of cancer. Other miRNAs can indicate the probable course of the disease or determine the survival prognosis. In addition, there is a growing interest directed at the understanding of miRNA-induced molecular mechanisms. The possibility of intervention in the molecular mechanisms of miRNAs regulation could begin a new generation of pancreatic cancer therapies. This review summarizes the recent reports describing functions of miRNAs in cellular processes underlying pancreatic cancerogenesis and their utility in diagnosis, survival prognosis, and therapy." @default.
- W2093622405 created "2016-06-24" @default.
- W2093622405 creator A5033228752 @default.
- W2093622405 creator A5052949409 @default.
- W2093622405 creator A5061530548 @default.
- W2093622405 creator A5065070816 @default.
- W2093622405 date "2015-01-01" @default.
- W2093622405 modified "2023-10-10" @default.
- W2093622405 title "MicroRNAs in Pancreatic Cancer: Involvement in Carcinogenesis and Potential Use for Diagnosis and Prognosis" @default.
- W2093622405 cites W1595577626 @default.
- W2093622405 cites W1671611542 @default.
- W2093622405 cites W1931508686 @default.
- W2093622405 cites W1964064067 @default.
- W2093622405 cites W1969208117 @default.
- W2093622405 cites W1969669359 @default.
- W2093622405 cites W1975412433 @default.
- W2093622405 cites W1976324983 @default.
- W2093622405 cites W1979538859 @default.
- W2093622405 cites W1979673666 @default.
- W2093622405 cites W1980244442 @default.
- W2093622405 cites W1981337389 @default.
- W2093622405 cites W1981889510 @default.
- W2093622405 cites W1983991097 @default.
- W2093622405 cites W1986042144 @default.
- W2093622405 cites W1986110037 @default.
- W2093622405 cites W1988927152 @default.
- W2093622405 cites W1989500961 @default.
- W2093622405 cites W1991988066 @default.
- W2093622405 cites W1992303379 @default.
- W2093622405 cites W1995399248 @default.
- W2093622405 cites W2000982792 @default.
- W2093622405 cites W2003334487 @default.
- W2093622405 cites W2004671522 @default.
- W2093622405 cites W2008945738 @default.
- W2093622405 cites W2014200421 @default.
- W2093622405 cites W2014783179 @default.
- W2093622405 cites W2019640214 @default.
- W2093622405 cites W2019867275 @default.
- W2093622405 cites W2020080445 @default.
- W2093622405 cites W2022916389 @default.
- W2093622405 cites W2023602651 @default.
- W2093622405 cites W2024585236 @default.
- W2093622405 cites W2026468262 @default.
- W2093622405 cites W2026595595 @default.
- W2093622405 cites W2035987476 @default.
- W2093622405 cites W2037044064 @default.
- W2093622405 cites W2038167014 @default.
- W2093622405 cites W2038699538 @default.
- W2093622405 cites W2040935952 @default.
- W2093622405 cites W2041282134 @default.
- W2093622405 cites W2047213909 @default.
- W2093622405 cites W2048607245 @default.
- W2093622405 cites W2051227958 @default.
- W2093622405 cites W2052783034 @default.
- W2093622405 cites W2056424427 @default.
- W2093622405 cites W2056494524 @default.
- W2093622405 cites W2059848983 @default.
- W2093622405 cites W2065827036 @default.
- W2093622405 cites W2066868410 @default.
- W2093622405 cites W2067708466 @default.
- W2093622405 cites W2068588364 @default.
- W2093622405 cites W2070602415 @default.
- W2093622405 cites W2071596702 @default.
- W2093622405 cites W2076118448 @default.
- W2093622405 cites W2078626338 @default.
- W2093622405 cites W2079251691 @default.
- W2093622405 cites W2083918554 @default.
- W2093622405 cites W2084169171 @default.
- W2093622405 cites W2088832018 @default.
- W2093622405 cites W2090268947 @default.
- W2093622405 cites W2090961656 @default.
- W2093622405 cites W2093894988 @default.
- W2093622405 cites W2098653030 @default.
- W2093622405 cites W2105632406 @default.
- W2093622405 cites W2106246776 @default.
- W2093622405 cites W2107723175 @default.
- W2093622405 cites W2108775841 @default.
- W2093622405 cites W2109694492 @default.
- W2093622405 cites W2111663113 @default.
- W2093622405 cites W2112087504 @default.
- W2093622405 cites W2112666597 @default.
- W2093622405 cites W2113311589 @default.
- W2093622405 cites W2113574124 @default.
- W2093622405 cites W2113601196 @default.
- W2093622405 cites W2115093090 @default.
- W2093622405 cites W2118407487 @default.
- W2093622405 cites W2123079914 @default.
- W2093622405 cites W2123962115 @default.
- W2093622405 cites W2124488916 @default.
- W2093622405 cites W2125120607 @default.
- W2093622405 cites W2129615821 @default.
- W2093622405 cites W2134021858 @default.
- W2093622405 cites W2135926882 @default.
- W2093622405 cites W2140737952 @default.
- W2093622405 cites W2142046891 @default.
- W2093622405 cites W2142636026 @default.
- W2093622405 cites W2142801414 @default.
- W2093622405 cites W2145820920 @default.