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• W2093639780 abstract "Primary brain injury in stroke is followed by an excitotoxic cascade, oxidative stress and further neural damage. Glutathione is critical and depleted in oxidative stress. Since cysteine is limiting in glutathione synthesis, this study investigated the effect of dietary sulfur amino acid (SAA) deficiency on neural damage in a rat model of global hemispheric hypoxia-ischemia (GHHI). Animals were fed with SAA deficient (deficient) or control diet for 3 days, subjected to right common carotid artery ligation and hypoxia, and diet continued for 3 more days. Histologically evaluated neural damage at 7 days post hypoxia-ischemia was greater in deficient rats, shown by mean (±SEM) global and hippocampal grid scores of 2.5±0.7 and 34.9±9.3%, respectively, vs. controls' scores of 0.1±0.1 and 0.1±0.1%, respectively. Mean brain (±SEM) reduced glutathione was not different between groups at 6 h post hypoxia-ischemia, but was decreased in deficient animals 3 days later in neocortex (1.46 μmoles/g wet weight±0.05 vs. 1.67±0.04 in controls) and thalamus (1.60 μmoles/g wet weight±0.05 vs. 1.78±0.03 in controls). Administration of a cysteine precursor to deficient animals did not ameliorate neural damage. These findings suggest that well-nourished but not deficient animals tolerate a mild brain insult. The decline in brain glutathione in the deficient animals may be one of several contributing mechanisms." @default.
• W2093639780 created "2016-06-24" @default.
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• W2093639780 date "2002-01-01" @default.
• W2093639780 modified "2023-09-27" @default.
• W2093639780 title "The Effects of Dietary Sulfur Amino Acid Deficiency on Rat Brain Glutathione Concentration and Neural Damage in Global Hemispheric Hypoxia-Ischemia" @default.
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• W2093639780 doi "https://doi.org/10.1080/1028415021000055952" @default.
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