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- W2093642906 abstract "5-methylnicotinamide is an inhibitor of poly(ADP-ribose) synthetase, and it enhances the cytotoxicity of alkylating agents and of radiation in mouse lymphoma L1210 cells. We have isolated a spontaneous variant L1210 cell which shows increased resistance to 5-methylnicotinamide and has a reduced potentiation of cell-killing by methylnitrosourea and by γ-radiation. This observation is further evidence in support of the participation of (ADP-ribose)n in DNA excision repair and in cell survival. This variant may be of use in the molecular analysis of this component of DNA repair." @default.
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- W2093642906 date "1980-10-01" @default.
- W2093642906 modified "2023-09-23" @default.
- W2093642906 title "5-Methylnicotinamide-resistant variant of mouse lymphoma L1210 cells" @default.
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- W2093642906 doi "https://doi.org/10.1016/0006-291x(80)90051-0" @default.
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