Matches in SemOpenAlex for { <https://semopenalex.org/work/W2093643588> ?p ?o ?g. }
- W2093643588 endingPage "581" @default.
- W2093643588 startingPage "572" @default.
- W2093643588 abstract "Mutations in the TRPS1 gene lead to the tricho-rhino-phalangeal syndrome, which is characterized by skeletal defects and abnormal hair development. The TRPS1 gene encodes an atypical member of the GATA-type family of transcription factors. Here we show that mice with a disrupted Trps1 gene develop a chondrodysplasia characterized by diminished chondrocyte proliferation and decreased apoptosis in growth plates. Our analyses revealed that Trps1 is a repressor of Stat3 expression, which in turn controls chondrocyte proliferation and survival by regulating the expression of cyclin D1 and Bcl2. Our conclusion is supported (i) by siRNA-mediated depletion of Stat3 in Trps1-deficient chondrocytes, which normalized the expression of cyclin D1 and Bcl2, (ii) by overexpression of Trps1 in ATDC5 chondrocytes, which diminished Stat3 levels and increased proliferation and apoptosis, and (iii) by mutational analysis of the GATA-binding sites in the Stat3 gene, which revealed that their integrity is critical for the direct association with Trps1 and for Trps1-mediated repression of Stat3. Altogether our findings identify Trps1 as a novel regulator of chondrocytes proliferation and survival through the control of Stat3 expression." @default.
- W2093643588 created "2016-06-24" @default.
- W2093643588 creator A5008868788 @default.
- W2093643588 creator A5012571112 @default.
- W2093643588 creator A5018676958 @default.
- W2093643588 creator A5018979358 @default.
- W2093643588 creator A5059584902 @default.
- W2093643588 creator A5062755297 @default.
- W2093643588 creator A5074285020 @default.
- W2093643588 creator A5079584981 @default.
- W2093643588 creator A5081852407 @default.
- W2093643588 creator A5084059039 @default.
- W2093643588 creator A5084231014 @default.
- W2093643588 date "2007-12-01" @default.
- W2093643588 modified "2023-09-24" @default.
- W2093643588 title "Trps1 regulates proliferation and apoptosis of chondrocytes through Stat3 signaling" @default.
- W2093643588 cites W1489960151 @default.
- W2093643588 cites W1569766571 @default.
- W2093643588 cites W1971019443 @default.
- W2093643588 cites W1977370355 @default.
- W2093643588 cites W1977967095 @default.
- W2093643588 cites W1979710500 @default.
- W2093643588 cites W1981166298 @default.
- W2093643588 cites W2004527202 @default.
- W2093643588 cites W2031368804 @default.
- W2093643588 cites W2037499635 @default.
- W2093643588 cites W2050341669 @default.
- W2093643588 cites W2060109348 @default.
- W2093643588 cites W2063098208 @default.
- W2093643588 cites W2068042118 @default.
- W2093643588 cites W2072788472 @default.
- W2093643588 cites W2079360448 @default.
- W2093643588 cites W2092261637 @default.
- W2093643588 cites W2099410181 @default.
- W2093643588 cites W2099555406 @default.
- W2093643588 cites W2103461739 @default.
- W2093643588 cites W2119100530 @default.
- W2093643588 cites W2120609024 @default.
- W2093643588 cites W2145133713 @default.
- W2093643588 cites W2146094329 @default.
- W2093643588 cites W2146857985 @default.
- W2093643588 cites W2163528858 @default.
- W2093643588 cites W2165982976 @default.
- W2093643588 cites W4237398626 @default.
- W2093643588 cites W4240710787 @default.
- W2093643588 cites W4249713142 @default.
- W2093643588 cites W4313347835 @default.
- W2093643588 doi "https://doi.org/10.1016/j.ydbio.2007.10.001" @default.
- W2093643588 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17997399" @default.
- W2093643588 hasPublicationYear "2007" @default.
- W2093643588 type Work @default.
- W2093643588 sameAs 2093643588 @default.
- W2093643588 citedByCount "104" @default.
- W2093643588 countsByYear W20936435882012 @default.
- W2093643588 countsByYear W20936435882013 @default.
- W2093643588 countsByYear W20936435882014 @default.
- W2093643588 countsByYear W20936435882015 @default.
- W2093643588 countsByYear W20936435882016 @default.
- W2093643588 countsByYear W20936435882017 @default.
- W2093643588 countsByYear W20936435882018 @default.
- W2093643588 countsByYear W20936435882019 @default.
- W2093643588 countsByYear W20936435882020 @default.
- W2093643588 countsByYear W20936435882021 @default.
- W2093643588 countsByYear W20936435882022 @default.
- W2093643588 countsByYear W20936435882023 @default.
- W2093643588 crossrefType "journal-article" @default.
- W2093643588 hasAuthorship W2093643588A5008868788 @default.
- W2093643588 hasAuthorship W2093643588A5012571112 @default.
- W2093643588 hasAuthorship W2093643588A5018676958 @default.
- W2093643588 hasAuthorship W2093643588A5018979358 @default.
- W2093643588 hasAuthorship W2093643588A5059584902 @default.
- W2093643588 hasAuthorship W2093643588A5062755297 @default.
- W2093643588 hasAuthorship W2093643588A5074285020 @default.
- W2093643588 hasAuthorship W2093643588A5079584981 @default.
- W2093643588 hasAuthorship W2093643588A5081852407 @default.
- W2093643588 hasAuthorship W2093643588A5084059039 @default.
- W2093643588 hasAuthorship W2093643588A5084231014 @default.
- W2093643588 hasConcept C104317684 @default.
- W2093643588 hasConcept C120089663 @default.
- W2093643588 hasConcept C150194340 @default.
- W2093643588 hasConcept C153911025 @default.
- W2093643588 hasConcept C158448853 @default.
- W2093643588 hasConcept C186310378 @default.
- W2093643588 hasConcept C190283241 @default.
- W2093643588 hasConcept C199835354 @default.
- W2093643588 hasConcept C202751555 @default.
- W2093643588 hasConcept C2778923194 @default.
- W2093643588 hasConcept C2781403057 @default.
- W2093643588 hasConcept C29537977 @default.
- W2093643588 hasConcept C502942594 @default.
- W2093643588 hasConcept C54355233 @default.
- W2093643588 hasConcept C62112901 @default.
- W2093643588 hasConcept C62478195 @default.
- W2093643588 hasConcept C86339819 @default.
- W2093643588 hasConcept C86803240 @default.
- W2093643588 hasConcept C95444343 @default.
- W2093643588 hasConceptScore W2093643588C104317684 @default.
- W2093643588 hasConceptScore W2093643588C120089663 @default.