Matches in SemOpenAlex for { <https://semopenalex.org/work/W2093650117> ?p ?o ?g. }
- W2093650117 endingPage "467" @default.
- W2093650117 startingPage "461" @default.
- W2093650117 abstract "CDK11p110 (cyclin-dependent kinase 11p110, formerly known as PITSLRE) is a member of the CDK superfamily. It associates with cyclin L and is involved in the regulation of transcription and in premRNA splicing. During staurosporine-, Fas- and tumour necrosis factor α-induced apoptosis, CDK11p110, is cleaved by caspases to generate smaller 46–50 kDa proteins containing the catalytic kinase domain. Ectopic expression of the caspase-processed form CDK11p46 induces apoptosis. The mechanisms that regulate activation and stability of CDK11 isoforms are still unclear. In the present study, we demonstrate that in human melanoma cells CDK11p110 and CDK11p46 interact with Hsp90 (heat-shock protein 90) and its co-chaperone cdc37. Furthermore, we show that the treatment of cells with the Hsp90-specific inhibitor geldanamycin leads to ubiquitination and enhanced degradation of both CDK11p110 and CDK11p46 through a proteasome-dependent pathway. We also determined that geldanamycin-triggered degradation of CDK11p46 slows down the progression of apoptosis. These results indicate that Hsp90 and cdc37 stabilize CDK11 kinase, and suggest that this stabilization is crucial for its pro-apoptotic function." @default.
- W2093650117 created "2016-06-24" @default.
- W2093650117 creator A5016199544 @default.
- W2093650117 creator A5091061674 @default.
- W2093650117 date "2004-12-07" @default.
- W2093650117 modified "2023-10-17" @default.
- W2093650117 title "Regulation of stability of cyclin-dependent kinase CDK11p110 and a caspase-processed form, CDK11p46, by Hsp90" @default.
- W2093650117 cites W1487458087 @default.
- W2093650117 cites W1489973637 @default.
- W2093650117 cites W1516006437 @default.
- W2093650117 cites W1555549645 @default.
- W2093650117 cites W1584701845 @default.
- W2093650117 cites W1785240290 @default.
- W2093650117 cites W1903912050 @default.
- W2093650117 cites W1966910195 @default.
- W2093650117 cites W1969434661 @default.
- W2093650117 cites W1974087698 @default.
- W2093650117 cites W1974723796 @default.
- W2093650117 cites W1981427321 @default.
- W2093650117 cites W1984182384 @default.
- W2093650117 cites W1985672745 @default.
- W2093650117 cites W1986242330 @default.
- W2093650117 cites W1992195472 @default.
- W2093650117 cites W1993444408 @default.
- W2093650117 cites W1997198762 @default.
- W2093650117 cites W1998627317 @default.
- W2093650117 cites W2001105873 @default.
- W2093650117 cites W2002588761 @default.
- W2093650117 cites W2010388401 @default.
- W2093650117 cites W2019850601 @default.
- W2093650117 cites W2031486619 @default.
- W2093650117 cites W2033318049 @default.
- W2093650117 cites W2035306088 @default.
- W2093650117 cites W2036904418 @default.
- W2093650117 cites W2042699875 @default.
- W2093650117 cites W2046044279 @default.
- W2093650117 cites W2061108580 @default.
- W2093650117 cites W2074579328 @default.
- W2093650117 cites W2082390299 @default.
- W2093650117 cites W2083078196 @default.
- W2093650117 cites W2087958744 @default.
- W2093650117 cites W2088938008 @default.
- W2093650117 cites W2089292957 @default.
- W2093650117 cites W2089865526 @default.
- W2093650117 cites W2096955693 @default.
- W2093650117 cites W2112030347 @default.
- W2093650117 cites W2112133866 @default.
- W2093650117 cites W2120316538 @default.
- W2093650117 cites W2120913484 @default.
- W2093650117 cites W2126581529 @default.
- W2093650117 cites W2127882116 @default.
- W2093650117 cites W2136809856 @default.
- W2093650117 cites W2137357847 @default.
- W2093650117 cites W2139306838 @default.
- W2093650117 cites W2150518523 @default.
- W2093650117 cites W2158797202 @default.
- W2093650117 cites W2160364430 @default.
- W2093650117 cites W2175029576 @default.
- W2093650117 cites W2334181606 @default.
- W2093650117 cites W4244307718 @default.
- W2093650117 doi "https://doi.org/10.1042/bj20040848" @default.
- W2093650117 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1134131" @default.
- W2093650117 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15344906" @default.
- W2093650117 hasPublicationYear "2004" @default.
- W2093650117 type Work @default.
- W2093650117 sameAs 2093650117 @default.
- W2093650117 citedByCount "24" @default.
- W2093650117 countsByYear W20936501172012 @default.
- W2093650117 countsByYear W20936501172013 @default.
- W2093650117 countsByYear W20936501172014 @default.
- W2093650117 countsByYear W20936501172015 @default.
- W2093650117 countsByYear W20936501172016 @default.
- W2093650117 countsByYear W20936501172018 @default.
- W2093650117 countsByYear W20936501172019 @default.
- W2093650117 countsByYear W20936501172020 @default.
- W2093650117 countsByYear W20936501172022 @default.
- W2093650117 crossrefType "journal-article" @default.
- W2093650117 hasAuthorship W2093650117A5016199544 @default.
- W2093650117 hasAuthorship W2093650117A5091061674 @default.
- W2093650117 hasBestOaLocation W20936501172 @default.
- W2093650117 hasConcept C104317684 @default.
- W2093650117 hasConcept C104615370 @default.
- W2093650117 hasConcept C124320809 @default.
- W2093650117 hasConcept C155985219 @default.
- W2093650117 hasConcept C184235292 @default.
- W2093650117 hasConcept C190283241 @default.
- W2093650117 hasConcept C205260736 @default.
- W2093650117 hasConcept C27740335 @default.
- W2093650117 hasConcept C2775932338 @default.
- W2093650117 hasConcept C2779084600 @default.
- W2093650117 hasConcept C2780297055 @default.
- W2093650117 hasConcept C29537977 @default.
- W2093650117 hasConcept C31573885 @default.
- W2093650117 hasConcept C55493867 @default.
- W2093650117 hasConcept C82495950 @default.
- W2093650117 hasConcept C86803240 @default.
- W2093650117 hasConcept C91096171 @default.
- W2093650117 hasConcept C95444343 @default.