Matches in SemOpenAlex for { <https://semopenalex.org/work/W209365524> ?p ?o ?g. }
Showing items 1 to 73 of
73
with 100 items per page.
- W209365524 endingPage "600" @default.
- W209365524 startingPage "598" @default.
- W209365524 abstract "Attachment of C3b to activators of the alternative pathway of complement results in a decrease in regulatory activity expressed by Factor H. Decay-accelerating factor (DAF) and Factor H were found to exhibit quantitatively similar decreases in regulatory activity toward the C3 convertase (C3b,Bb) bound to activators, such as zymosan (Zym) and rabbit erythrocytes (ER), compared to non-activators, such as sheep (ES) and bovine (EB) erythrocytes. Purified DAF and Factor H, in 0.1% NP-40, were assayed by measuring the amount required to release 50% of the radiolabelled Bb in 10 min from C3b,Bb on Zym or cross-linked erythrocytes. The relative effectiveness (i.e. the restriction index, RI) of DAF for accelerating the decay of C3b,Bb on the various particles was: ES (1.0), ER (0.04) and Zym (0.03). The RI for Factor H was: ES (1.0), ER (0.04) and Zym (0.07). The rate of decay of C3b,Bb induced by DAF and Factor H showed similar restriction. The results suggest that the regulatory properties of DAF are reduced if the cells on which it resides become activators of the alternative pathway as a result of transformation, virus infection or surface alteration. These findings may explain reports of dysfunctional DAF on alternative pathway-activating cells." @default.
- W209365524 created "2016-06-24" @default.
- W209365524 creator A5041083283 @default.
- W209365524 date "1990-12-01" @default.
- W209365524 modified "2023-09-24" @default.
- W209365524 title "Reduced activity of DAF on complement enzymes bound to alternative pathway activators. Similarity with Factor H." @default.
- W209365524 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1384886" @default.
- W209365524 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1703989" @default.
- W209365524 hasPublicationYear "1990" @default.
- W209365524 type Work @default.
- W209365524 sameAs 209365524 @default.
- W209365524 citedByCount "2" @default.
- W209365524 crossrefType "journal-article" @default.
- W209365524 hasAuthorship W209365524A5041083283 @default.
- W209365524 hasConcept C111684460 @default.
- W209365524 hasConcept C14356644 @default.
- W209365524 hasConcept C153911025 @default.
- W209365524 hasConcept C159654299 @default.
- W209365524 hasConcept C181199279 @default.
- W209365524 hasConcept C182629451 @default.
- W209365524 hasConcept C189446657 @default.
- W209365524 hasConcept C202751555 @default.
- W209365524 hasConcept C203014093 @default.
- W209365524 hasConcept C2778870864 @default.
- W209365524 hasConcept C55493867 @default.
- W209365524 hasConcept C8487232 @default.
- W209365524 hasConcept C86803240 @default.
- W209365524 hasConcept C9478725 @default.
- W209365524 hasConceptScore W209365524C111684460 @default.
- W209365524 hasConceptScore W209365524C14356644 @default.
- W209365524 hasConceptScore W209365524C153911025 @default.
- W209365524 hasConceptScore W209365524C159654299 @default.
- W209365524 hasConceptScore W209365524C181199279 @default.
- W209365524 hasConceptScore W209365524C182629451 @default.
- W209365524 hasConceptScore W209365524C189446657 @default.
- W209365524 hasConceptScore W209365524C202751555 @default.
- W209365524 hasConceptScore W209365524C203014093 @default.
- W209365524 hasConceptScore W209365524C2778870864 @default.
- W209365524 hasConceptScore W209365524C55493867 @default.
- W209365524 hasConceptScore W209365524C8487232 @default.
- W209365524 hasConceptScore W209365524C86803240 @default.
- W209365524 hasConceptScore W209365524C9478725 @default.
- W209365524 hasIssue "4" @default.
- W209365524 hasLocation W2093655241 @default.
- W209365524 hasOpenAccess W209365524 @default.
- W209365524 hasPrimaryLocation W2093655241 @default.
- W209365524 hasRelatedWork W1484225284 @default.
- W209365524 hasRelatedWork W1518532260 @default.
- W209365524 hasRelatedWork W1548166821 @default.
- W209365524 hasRelatedWork W1550517269 @default.
- W209365524 hasRelatedWork W1551112026 @default.
- W209365524 hasRelatedWork W1866736421 @default.
- W209365524 hasRelatedWork W1872408728 @default.
- W209365524 hasRelatedWork W1936615645 @default.
- W209365524 hasRelatedWork W1972398559 @default.
- W209365524 hasRelatedWork W1983395201 @default.
- W209365524 hasRelatedWork W2021620327 @default.
- W209365524 hasRelatedWork W2076082618 @default.
- W209365524 hasRelatedWork W2088497640 @default.
- W209365524 hasRelatedWork W2097781680 @default.
- W209365524 hasRelatedWork W2132566631 @default.
- W209365524 hasRelatedWork W2152356475 @default.
- W209365524 hasRelatedWork W2324494420 @default.
- W209365524 hasRelatedWork W2339037907 @default.
- W209365524 hasRelatedWork W2405936392 @default.
- W209365524 hasRelatedWork W2980129206 @default.
- W209365524 hasVolume "71" @default.
- W209365524 isParatext "false" @default.
- W209365524 isRetracted "false" @default.
- W209365524 magId "209365524" @default.
- W209365524 workType "article" @default.