FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2093658225> ?p ?o ?g. }

• W2093658225 endingPage "669" @default.
• W2093658225 startingPage "665" @default.
• W2093658225 abstract "The objective of our present study was to develop a warfarin dosing algorithm for the Omani patients, as performances of warfarin dosing algorithms vary across populations with impact on the daily maintenance dose. We studied the functional polymorphisms of CYP2C9, CYP4F2 and VKORC1 genes to evaluate their impact on the warfarin maintenance dose in an admixed Omani patient cohort with Caucasian, African and Asian ancestries. We observed a 64-fold inter-patient variability for warfarin to achieve stable international normalized ratio in these patients. Univariate analysis revealed that age, gender, weight, atrial fibrillation, deep vein thrombosis/pulmonary embolism and variant genotypes of CYP2C9 and VKORC1 loci were significantly associated with warfarin dose in the studied patient population. However, multiple regression model showed that only the atrial fibrillation, and homozygous CYP2C9 variant genotypes (*2/*3 and *3/*3) and VKORC1 GA and AA genotypes remained significant. A multivariate model, which included demographic, clinical and pharmacogenetic variables together explained 63% of the overall inter-patient variability in warfarin dose requirement in this microgeographically defined, ethnically admixed Omani patient cohort on warfarin. This locally developed model performed much better than the International Warfarin Pharmacogenetics Consortium (IWPC) model as the latter could only explain 34% of the inter-patient variability in Omani patients. VKORC1 3673G>A polymorphism emerged as the single most important predictor of warfarin dose variability, even in this admixed population (partial R2=0.45)." @default.
• W2093658225 created "2016-06-24" @default.
• W2093658225 creator A5020074672 @default.
• W2093658225 creator A5027670612 @default.
• W2093658225 creator A5034369403 @default.
• W2093658225 creator A5044688594 @default.
• W2093658225 creator A5049941422 @default.
• W2093658225 creator A5055401424 @default.
• W2093658225 creator A5059563268 @default.
• W2093658225 creator A5065908058 @default.
• W2093658225 creator A5080988958 @default.
• W2093658225 date "2012-08-02" @default.
• W2093658225 modified "2023-10-12" @default.
• W2093658225 title "Warfarin pharmacogenetics: development of a dosing algorithm for Omani patients" @default.
• W2093658225 cites W1515782956 @default.
• W2093658225 cites W1905856654 @default.
• W2093658225 cites W1984715426 @default.
• W2093658225 cites W1997429036 @default.
• W2093658225 cites W2006484761 @default.
• W2093658225 cites W2006914590 @default.
• W2093658225 cites W2016935074 @default.
• W2093658225 cites W2017538702 @default.
• W2093658225 cites W2020554169 @default.
• W2093658225 cites W2025626547 @default.
• W2093658225 cites W2037171637 @default.
• W2093658225 cites W2043674997 @default.
• W2093658225 cites W2060258790 @default.
• W2093658225 cites W2068476516 @default.
• W2093658225 cites W2074183872 @default.
• W2093658225 cites W2079096317 @default.
• W2093658225 cites W2101980933 @default.
• W2093658225 cites W2115471029 @default.
• W2093658225 cites W2116304562 @default.
• W2093658225 cites W2126321110 @default.
• W2093658225 cites W2151936813 @default.
• W2093658225 cites W2157082037 @default.
• W2093658225 cites W2159208695 @default.
• W2093658225 doi "https://doi.org/10.1038/jhg.2012.94" @default.
• W2093658225 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22854539" @default.
• W2093658225 hasPublicationYear "2012" @default.
• W2093658225 type Work @default.
• W2093658225 sameAs 2093658225 @default.
• W2093658225 citedByCount "28" @default.
• W2093658225 countsByYear W20936582252012 @default.
• W2093658225 countsByYear W20936582252013 @default.
• W2093658225 countsByYear W20936582252014 @default.
• W2093658225 countsByYear W20936582252015 @default.
• W2093658225 countsByYear W20936582252016 @default.
• W2093658225 countsByYear W20936582252017 @default.
• W2093658225 countsByYear W20936582252018 @default.
• W2093658225 countsByYear W20936582252019 @default.
• W2093658225 countsByYear W20936582252020 @default.
• W2093658225 countsByYear W20936582252021 @default.
• W2093658225 countsByYear W20936582252022 @default.
• W2093658225 countsByYear W20936582252023 @default.
• W2093658225 crossrefType "journal-article" @default.
• W2093658225 hasAuthorship W2093658225A5020074672 @default.
• W2093658225 hasAuthorship W2093658225A5027670612 @default.
• W2093658225 hasAuthorship W2093658225A5034369403 @default.
• W2093658225 hasAuthorship W2093658225A5044688594 @default.
• W2093658225 hasAuthorship W2093658225A5049941422 @default.
• W2093658225 hasAuthorship W2093658225A5055401424 @default.
• W2093658225 hasAuthorship W2093658225A5059563268 @default.
• W2093658225 hasAuthorship W2093658225A5065908058 @default.
• W2093658225 hasAuthorship W2093658225A5080988958 @default.
• W2093658225 hasBestOaLocation W20936582251 @default.
• W2093658225 hasConcept C104317684 @default.
• W2093658225 hasConcept C126322002 @default.
• W2093658225 hasConcept C135763542 @default.
• W2093658225 hasConcept C2776301958 @default.
• W2093658225 hasConcept C2776318485 @default.
• W2093658225 hasConcept C2776765323 @default.
• W2093658225 hasConcept C2777288759 @default.
• W2093658225 hasConcept C2779161974 @default.
• W2093658225 hasConcept C27924281 @default.
• W2093658225 hasConcept C2908647359 @default.
• W2093658225 hasConcept C3946865 @default.
• W2093658225 hasConcept C526171541 @default.
• W2093658225 hasConcept C54355233 @default.
• W2093658225 hasConcept C55775858 @default.
• W2093658225 hasConcept C62231903 @default.
• W2093658225 hasConcept C71924100 @default.
• W2093658225 hasConcept C72563966 @default.
• W2093658225 hasConcept C86803240 @default.
• W2093658225 hasConcept C99454951 @default.
• W2093658225 hasConceptScore W2093658225C104317684 @default.
• W2093658225 hasConceptScore W2093658225C126322002 @default.
• W2093658225 hasConceptScore W2093658225C135763542 @default.
• W2093658225 hasConceptScore W2093658225C2776301958 @default.
• W2093658225 hasConceptScore W2093658225C2776318485 @default.
• W2093658225 hasConceptScore W2093658225C2776765323 @default.
• W2093658225 hasConceptScore W2093658225C2777288759 @default.
• W2093658225 hasConceptScore W2093658225C2779161974 @default.
• W2093658225 hasConceptScore W2093658225C27924281 @default.
• W2093658225 hasConceptScore W2093658225C2908647359 @default.
• W2093658225 hasConceptScore W2093658225C3946865 @default.
• W2093658225 hasConceptScore W2093658225C526171541 @default.
• W2093658225 hasConceptScore W2093658225C54355233 @default.

• next