FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2093661044> ?p ?o ?g. }

• W2093661044 endingPage "3022" @default.
• W2093661044 startingPage "3017" @default.
• W2093661044 abstract "The crystal structure of intercellular adhesion molecule-2 (ICAM-2) revealed significant differences in the presentation of the critical acidic residue important for integrin binding between I and non-I-domain integrin ligands. Based on this crystal structure, we mutagenized ICAM-2 to localize the binding site for the integrin lymphocyte function-associated antigen-1 (LFA-1). The integrin binding site runs diagonally across the GFC β-sheet and includes residues on the CD edge of the β-sandwich. The site is oblong and runs along a flat ridge on the upper half of domain 1, which is proposed to dock to a groove in the I domain of LFA-1, with the critical Glu-37 residue ligating the Mg 2+ in the I domain. Previous mutagenesis of ICAM-1 and ICAM-3, interpreted in light of the recently determined ICAM-1 and ICAM-2 structures, suggests similar binding sites. By contrast, major differences are seen with vascular cell adhesion molecule-1 (VCAM-1), which binds α 4 integrins that lack an I domain. The binding site on VCAM-1 includes the lower portion of domain 1 and the upper part of domain 2, whereas the LFA-1 binding site on ICAM is confined to the upper part of domain 1." @default.
• W2093661044 created "2016-06-24" @default.
• W2093661044 creator A5003615852 @default.
• W2093661044 creator A5019041253 @default.
• W2093661044 creator A5059830031 @default.
• W2093661044 date "1999-03-16" @default.
• W2093661044 modified "2023-09-27" @default.
• W2093661044 title "Lymphocyte function-associated antigen-1 binding residues in intercellular adhesion molecule-2 (ICAM-2) and the integrin binding surface in the ICAM subfamily" @default.
• W2093661044 cites W1523384705 @default.
• W2093661044 cites W1550140963 @default.
• W2093661044 cites W1555059577 @default.
• W2093661044 cites W1608238983 @default.
• W2093661044 cites W1651594003 @default.
• W2093661044 cites W1754157939 @default.
• W2093661044 cites W1964638756 @default.
• W2093661044 cites W1972470306 @default.
• W2093661044 cites W1988719059 @default.
• W2093661044 cites W1991022642 @default.
• W2093661044 cites W2001790124 @default.
• W2093661044 cites W2004374847 @default.
• W2093661044 cites W2008708467 @default.
• W2093661044 cites W2020971843 @default.
• W2093661044 cites W2023610452 @default.
• W2093661044 cites W2037672200 @default.
• W2093661044 cites W2039805883 @default.
• W2093661044 cites W2052043921 @default.
• W2093661044 cites W2054088267 @default.
• W2093661044 cites W2057784785 @default.
• W2093661044 cites W2069911462 @default.
• W2093661044 cites W2074619197 @default.
• W2093661044 cites W2081029926 @default.
• W2093661044 cites W2084762695 @default.
• W2093661044 cites W2092017901 @default.
• W2093661044 cites W2099675490 @default.
• W2093661044 cites W2104821162 @default.
• W2093661044 cites W2107553760 @default.
• W2093661044 cites W2140305004 @default.
• W2093661044 cites W2141699093 @default.
• W2093661044 cites W2157015192 @default.
• W2093661044 cites W2160378662 @default.
• W2093661044 cites W2220655641 @default.
• W2093661044 doi "https://doi.org/10.1073/pnas.96.6.3017" @default.
• W2093661044 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/15887" @default.
• W2093661044 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10077629" @default.
• W2093661044 hasPublicationYear "1999" @default.
• W2093661044 type Work @default.
• W2093661044 sameAs 2093661044 @default.
• W2093661044 citedByCount "32" @default.
• W2093661044 countsByYear W20936610442013 @default.
• W2093661044 countsByYear W20936610442014 @default.
• W2093661044 countsByYear W20936610442015 @default.
• W2093661044 countsByYear W20936610442016 @default.
• W2093661044 countsByYear W20936610442017 @default.
• W2093661044 countsByYear W20936610442018 @default.
• W2093661044 countsByYear W20936610442022 @default.
• W2093661044 crossrefType "journal-article" @default.
• W2093661044 hasAuthorship W2093661044A5003615852 @default.
• W2093661044 hasAuthorship W2093661044A5019041253 @default.
• W2093661044 hasAuthorship W2093661044A5059830031 @default.
• W2093661044 hasBestOaLocation W20936610441 @default.
• W2093661044 hasConcept C107824862 @default.
• W2093661044 hasConcept C12554922 @default.
• W2093661044 hasConcept C134659918 @default.
• W2093661044 hasConcept C1491633281 @default.
• W2093661044 hasConcept C16224149 @default.
• W2093661044 hasConcept C170493617 @default.
• W2093661044 hasConcept C185592680 @default.
• W2093661044 hasConcept C195687474 @default.
• W2093661044 hasConcept C2778593620 @default.
• W2093661044 hasConcept C2909375385 @default.
• W2093661044 hasConcept C55493867 @default.
• W2093661044 hasConcept C85789140 @default.
• W2093661044 hasConcept C86803240 @default.
• W2093661044 hasConcept C95444343 @default.
• W2093661044 hasConceptScore W2093661044C107824862 @default.
• W2093661044 hasConceptScore W2093661044C12554922 @default.
• W2093661044 hasConceptScore W2093661044C134659918 @default.
• W2093661044 hasConceptScore W2093661044C1491633281 @default.
• W2093661044 hasConceptScore W2093661044C16224149 @default.
• W2093661044 hasConceptScore W2093661044C170493617 @default.
• W2093661044 hasConceptScore W2093661044C185592680 @default.
• W2093661044 hasConceptScore W2093661044C195687474 @default.
• W2093661044 hasConceptScore W2093661044C2778593620 @default.
• W2093661044 hasConceptScore W2093661044C2909375385 @default.
• W2093661044 hasConceptScore W2093661044C55493867 @default.
• W2093661044 hasConceptScore W2093661044C85789140 @default.
• W2093661044 hasConceptScore W2093661044C86803240 @default.
• W2093661044 hasConceptScore W2093661044C95444343 @default.
• W2093661044 hasIssue "6" @default.
• W2093661044 hasLocation W20936610441 @default.
• W2093661044 hasLocation W20936610442 @default.
• W2093661044 hasLocation W20936610443 @default.
• W2093661044 hasLocation W20936610444 @default.
• W2093661044 hasOpenAccess W2093661044 @default.
• W2093661044 hasPrimaryLocation W20936610441 @default.
• W2093661044 hasRelatedWork W1967573362 @default.
• W2093661044 hasRelatedWork W1990330796 @default.
• W2093661044 hasRelatedWork W1991995593 @default.

• next