FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2093667089> ?p ?o ?g. }

• W2093667089 endingPage "2783" @default.
• W2093667089 startingPage "2774" @default.
• W2093667089 abstract "Abstract The human plasma protein β2-glycoprotein I (β2-GPI) is the major target of autoantibodies associated with antiphospholipid syndrome. However, the biologic function of this abundant protein is still unclear. Here we identify β2-GPI as a complement regulator. β2-GPI circulates in the plasma in an inactive circular form. On surface binding, such as to apoptotic cells, β2-GPI changes conformation to an elongated form that acquires C3/C3b binding activities. β2-GPI apparently changes conformation of C3, so that the regulator factor H attaches and induces subsequent degradation by the protease factor I. β2-GPI also mediates further cleavage of C3/C3b compared with factor H alone. Our data provide important insights into innate immune regulation by plasma protein β2-GPI, which may be exploited in the prevention and therapy of autoimmune disease antiphospholipid syndrome." @default.
• W2093667089 created "2016-06-24" @default.
• W2093667089 creator A5013169595 @default.
• W2093667089 creator A5016671333 @default.
• W2093667089 creator A5045171143 @default.
• W2093667089 creator A5064615638 @default.
• W2093667089 creator A5065108689 @default.
• W2093667089 creator A5074615051 @default.
• W2093667089 creator A5081808654 @default.
• W2093667089 date "2011-09-08" @default.
• W2093667089 modified "2023-09-27" @default.
• W2093667089 title "β2-glycoprotein I, the major target in antiphospholipid syndrome, is a special human complement regulator" @default.
• W2093667089 cites W1500801849 @default.
• W2093667089 cites W1766730806 @default.
• W2093667089 cites W1923802408 @default.
• W2093667089 cites W1939870037 @default.
• W2093667089 cites W1973359543 @default.
• W2093667089 cites W1977109595 @default.
• W2093667089 cites W1980635457 @default.
• W2093667089 cites W1991721757 @default.
• W2093667089 cites W1995507202 @default.
• W2093667089 cites W2000886437 @default.
• W2093667089 cites W2010518173 @default.
• W2093667089 cites W2013188880 @default.
• W2093667089 cites W2014456395 @default.
• W2093667089 cites W2037699290 @default.
• W2093667089 cites W2046838002 @default.
• W2093667089 cites W2051279034 @default.
• W2093667089 cites W2053398588 @default.
• W2093667089 cites W2058984594 @default.
• W2093667089 cites W2075445217 @default.
• W2093667089 cites W2079127176 @default.
• W2093667089 cites W2084233988 @default.
• W2093667089 cites W2089900609 @default.
• W2093667089 cites W2093223457 @default.
• W2093667089 cites W2096428341 @default.
• W2093667089 cites W2097046783 @default.
• W2093667089 cites W2101831374 @default.
• W2093667089 cites W2102727554 @default.
• W2093667089 cites W2109060641 @default.
• W2093667089 cites W2113891001 @default.
• W2093667089 cites W2120945493 @default.
• W2093667089 cites W2134496796 @default.
• W2093667089 cites W2136648677 @default.
• W2093667089 cites W2143891179 @default.
• W2093667089 cites W2148045758 @default.
• W2093667089 cites W2151163209 @default.
• W2093667089 cites W2152403136 @default.
• W2093667089 cites W2160957830 @default.
• W2093667089 cites W3021852519 @default.
• W2093667089 cites W4239387674 @default.
• W2093667089 doi "https://doi.org/10.1182/blood-2011-02-339564" @default.
• W2093667089 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21757614" @default.
• W2093667089 hasPublicationYear "2011" @default.
• W2093667089 type Work @default.
• W2093667089 sameAs 2093667089 @default.
• W2093667089 citedByCount "75" @default.
• W2093667089 countsByYear W20936670892012 @default.
• W2093667089 countsByYear W20936670892013 @default.
• W2093667089 countsByYear W20936670892014 @default.
• W2093667089 countsByYear W20936670892015 @default.
• W2093667089 countsByYear W20936670892016 @default.
• W2093667089 countsByYear W20936670892017 @default.
• W2093667089 countsByYear W20936670892018 @default.
• W2093667089 countsByYear W20936670892019 @default.
• W2093667089 countsByYear W20936670892020 @default.
• W2093667089 countsByYear W20936670892021 @default.
• W2093667089 countsByYear W20936670892022 @default.
• W2093667089 countsByYear W20936670892023 @default.
• W2093667089 crossrefType "journal-article" @default.
• W2093667089 hasAuthorship W2093667089A5013169595 @default.
• W2093667089 hasAuthorship W2093667089A5016671333 @default.
• W2093667089 hasAuthorship W2093667089A5045171143 @default.
• W2093667089 hasAuthorship W2093667089A5064615638 @default.
• W2093667089 hasAuthorship W2093667089A5065108689 @default.
• W2093667089 hasAuthorship W2093667089A5074615051 @default.
• W2093667089 hasAuthorship W2093667089A5081808654 @default.
• W2093667089 hasBestOaLocation W20936670891 @default.
• W2093667089 hasConcept C104317684 @default.
• W2093667089 hasConcept C108625454 @default.
• W2093667089 hasConcept C111684460 @default.
• W2093667089 hasConcept C14356644 @default.
• W2093667089 hasConcept C153911025 @default.
• W2093667089 hasConcept C159654299 @default.
• W2093667089 hasConcept C163764329 @default.
• W2093667089 hasConcept C179369057 @default.
• W2093667089 hasConcept C185592680 @default.
• W2093667089 hasConcept C189446657 @default.
• W2093667089 hasConcept C203014093 @default.
• W2093667089 hasConcept C2776874634 @default.
• W2093667089 hasConcept C55493867 @default.
• W2093667089 hasConcept C6929976 @default.
• W2093667089 hasConcept C8487232 @default.
• W2093667089 hasConcept C86803240 @default.
• W2093667089 hasConcept C8891405 @default.
• W2093667089 hasConcept C95444343 @default.
• W2093667089 hasConceptScore W2093667089C104317684 @default.
• W2093667089 hasConceptScore W2093667089C108625454 @default.

• next