FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2093670228> ?p ?o ?g. }

• W2093670228 endingPage "135" @default.
• W2093670228 startingPage "135" @default.
• W2093670228 abstract "Translationally controlled tumour protein (TCTP), a well known protein of the animal kingdom, was shown to be a Ca(2+)-binding protein with important functions in many different cellular processes (e.g. protection against stress and apoptosis, cell growth, cell cycle progression, and microtubule organization). However, only little is known about TCTP in plants. Transcript and protein levels of plant TCTPs were shown to be altered by various stress conditions (e.g. cold, salt, draught, aluminium, and pathogen infection), and Arabidopsis thaliana TCTP (AtTCTP) was described as an important regulator of growth. The aim of this study was to further characterize plant TCTP relating to one of its major functions in animals: the protection against cell death.We used two different activators of programmed cell death (PCD) in plants: the mammalian pro-apoptotic protein BAX and tunicamycin, an inhibitor of glycosylation and trigger of unfolded protein response (UPR). Over-expression of AtTCTP significantly decreased cell death in tobacco leaf discs in both studies. A (45)Ca overlay assay showed AtTCTP to be a Ca(2+)-binding protein and localization experiments revealed cytosolic distribution of AtTCTP-GFP in Arabidopsis seedlings.Our study showed cytoprotective effects of plant TCTP for the first time. Furthermore, we showed the ability of AtTCTP to bind to Ca(2+) and its cytosolic distribution within the cell. If these results are combined, two putative modes of action can be assumed: 1) AtTCTP acts as Ca(2+) sequester, preventing PCD by reducing cytosolic Ca(2+) levels as described for animals. 2) AtTCTP could directly or indirectly interact with other cytosolic or membrane-bound proteins of the cell death machinery, thereby inhibiting cell death progression. As no homologous proteins of the anti-apoptotic machinery of animals were found in plants, and functional homologues still remain to be elucidated, future work will provide more insight." @default.
• W2093670228 created "2016-06-24" @default.
• W2093670228 creator A5000117477 @default.
• W2093670228 creator A5015240382 @default.
• W2093670228 creator A5049919596 @default.
• W2093670228 creator A5057418565 @default.
• W2093670228 creator A5067216022 @default.
• W2093670228 date "2013-01-01" @default.
• W2093670228 modified "2023-10-08" @default.
• W2093670228 title "The effect of Translationally Controlled Tumour Protein (TCTP) on programmed cell death in plants" @default.
• W2093670228 cites W1553351323 @default.
• W2093670228 cites W1564466158 @default.
• W2093670228 cites W1576693474 @default.
• W2093670228 cites W1966827575 @default.
• W2093670228 cites W1977352336 @default.
• W2093670228 cites W1981423208 @default.
• W2093670228 cites W1994771683 @default.
• W2093670228 cites W2001917210 @default.
• W2093670228 cites W2004689990 @default.
• W2093670228 cites W2009111926 @default.
• W2093670228 cites W2012751277 @default.
• W2093670228 cites W2016851054 @default.
• W2093670228 cites W2023926016 @default.
• W2093670228 cites W2026459518 @default.
• W2093670228 cites W2027783756 @default.
• W2093670228 cites W2039042438 @default.
• W2093670228 cites W2041935120 @default.
• W2093670228 cites W2045425335 @default.
• W2093670228 cites W2065258417 @default.
• W2093670228 cites W2069363008 @default.
• W2093670228 cites W2074795091 @default.
• W2093670228 cites W2077701124 @default.
• W2093670228 cites W2081465644 @default.
• W2093670228 cites W2082930542 @default.
• W2093670228 cites W2084498285 @default.
• W2093670228 cites W2098545111 @default.
• W2093670228 cites W2137945141 @default.
• W2093670228 cites W2140528190 @default.
• W2093670228 cites W2140919652 @default.
• W2093670228 cites W2149836952 @default.
• W2093670228 cites W2150239963 @default.
• W2093670228 cites W2157744273 @default.
• W2093670228 cites W2158386421 @default.
• W2093670228 cites W2159615505 @default.
• W2093670228 cites W2165064047 @default.
• W2093670228 cites W269103602 @default.
• W2093670228 doi "https://doi.org/10.1186/1471-2229-13-135" @default.
• W2093670228 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3847524" @default.
• W2093670228 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24040826" @default.
• W2093670228 hasPublicationYear "2013" @default.
• W2093670228 type Work @default.
• W2093670228 sameAs 2093670228 @default.
• W2093670228 citedByCount "45" @default.
• W2093670228 countsByYear W20936702282014 @default.
• W2093670228 countsByYear W20936702282015 @default.
• W2093670228 countsByYear W20936702282016 @default.
• W2093670228 countsByYear W20936702282017 @default.
• W2093670228 countsByYear W20936702282018 @default.
• W2093670228 countsByYear W20936702282019 @default.
• W2093670228 countsByYear W20936702282020 @default.
• W2093670228 countsByYear W20936702282021 @default.
• W2093670228 countsByYear W20936702282022 @default.
• W2093670228 countsByYear W20936702282023 @default.
• W2093670228 crossrefType "journal-article" @default.
• W2093670228 hasAuthorship W2093670228A5000117477 @default.
• W2093670228 hasAuthorship W2093670228A5015240382 @default.
• W2093670228 hasAuthorship W2093670228A5049919596 @default.
• W2093670228 hasAuthorship W2093670228A5057418565 @default.
• W2093670228 hasAuthorship W2093670228A5067216022 @default.
• W2093670228 hasBestOaLocation W20936702281 @default.
• W2093670228 hasConcept C104317684 @default.
• W2093670228 hasConcept C131312102 @default.
• W2093670228 hasConcept C134459356 @default.
• W2093670228 hasConcept C139447449 @default.
• W2093670228 hasConcept C143065580 @default.
• W2093670228 hasConcept C156203801 @default.
• W2093670228 hasConcept C158617107 @default.
• W2093670228 hasConcept C181199279 @default.
• W2093670228 hasConcept C190283241 @default.
• W2093670228 hasConcept C25602115 @default.
• W2093670228 hasConcept C2775988993 @default.
• W2093670228 hasConcept C2777575526 @default.
• W2093670228 hasConcept C2779491563 @default.
• W2093670228 hasConcept C31573885 @default.
• W2093670228 hasConcept C55493867 @default.
• W2093670228 hasConcept C86803240 @default.
• W2093670228 hasConcept C95444343 @default.
• W2093670228 hasConcept C98539663 @default.
• W2093670228 hasConceptScore W2093670228C104317684 @default.
• W2093670228 hasConceptScore W2093670228C131312102 @default.
• W2093670228 hasConceptScore W2093670228C134459356 @default.
• W2093670228 hasConceptScore W2093670228C139447449 @default.
• W2093670228 hasConceptScore W2093670228C143065580 @default.
• W2093670228 hasConceptScore W2093670228C156203801 @default.
• W2093670228 hasConceptScore W2093670228C158617107 @default.
• W2093670228 hasConceptScore W2093670228C181199279 @default.
• W2093670228 hasConceptScore W2093670228C190283241 @default.
• W2093670228 hasConceptScore W2093670228C25602115 @default.

• next