Matches in SemOpenAlex for { <https://semopenalex.org/work/W2093670351> ?p ?o ?g. }
- W2093670351 endingPage "339" @default.
- W2093670351 startingPage "331" @default.
- W2093670351 abstract "Nineteen naturally occurring amino acids were administered intracranially to day-old chicks at various times before and after a single trial passive avoidance learning task. The results suggest a consistent and simple difference between essential and non-essential amino acids. Except for arginine, phenylalanine, tryptophan and tyrosine, the essential amino acids had no effect on memory formation when administered 5 min before or immediately after learning. However, arginine, phenylalanine and tryptophan yielded amnesia after 60 min following learning, when given between 5 min before and 2.5 min after learning. In the case of tryptophan, amnesia was only temporary, lasting from 60 min to 240 min post-learning. All non-essential amino acids, when administered between 5 min before and 5 min after learning, yielded amnesia by 60 min post-learning, with no evidence of recovery by 24 hr post-learning. Alanine-, asparagine-, cysteine- and glutamate-treated chicks, however, showed signs of generalized avoidance shortly after administration. The retention time courses after injection of glutamine, proline, serine and taurine were similar to that obtained with the non-metabolizable amino acid α -amino-isobutyric acid, and amnesia arising from administration of these amino acids was counteracted by diphenylhydantoin, as was amnesia induced by phenylalanine and tyrosine. The retention function obtained with tryptophan was similar to that obtained with 5-hydroxytryptamine, and DPH had no effect on the action of tryptophan or the actions of arginine, alanine or asparagine. The findings were interpreted in the context of a three-stage model of memory formation. In particular, all amino acids which produced amnesia, except for tryptophan, appeared to inhibit formation of the protein synthesis-dependent long-term memory stage, and may exert their effects through interference with the uptake or the balance of amino acids necessary for LTM-related protein synthesis. The finding that non-essential amino acids proved more critical than essential amino acids may be due to the possibility that levels of essential amino acids may be expected to fluctuate with dietary conditions more than non-essential amino acids. Hence, fundamental processes such as memory formation may be expected to be less susceptible to such fluctuation." @default.
- W2093670351 created "2016-06-24" @default.
- W2093670351 creator A5047240384 @default.
- W2093670351 creator A5074071398 @default.
- W2093670351 creator A5086871900 @default.
- W2093670351 date "1987-09-01" @default.
- W2093670351 modified "2023-09-26" @default.
- W2093670351 title "Effect of excess intracranial amino acids on memory: A behavioural survey" @default.
- W2093670351 cites W16603568 @default.
- W2093670351 cites W1854223427 @default.
- W2093670351 cites W1903552917 @default.
- W2093670351 cites W1964533428 @default.
- W2093670351 cites W1966897875 @default.
- W2093670351 cites W1982878777 @default.
- W2093670351 cites W1984882670 @default.
- W2093670351 cites W1990546626 @default.
- W2093670351 cites W1993048108 @default.
- W2093670351 cites W1997066967 @default.
- W2093670351 cites W200284424 @default.
- W2093670351 cites W2003198568 @default.
- W2093670351 cites W2015896064 @default.
- W2093670351 cites W2017180584 @default.
- W2093670351 cites W2019040520 @default.
- W2093670351 cites W2023567448 @default.
- W2093670351 cites W2025077434 @default.
- W2093670351 cites W2034910577 @default.
- W2093670351 cites W2040263305 @default.
- W2093670351 cites W2040329887 @default.
- W2093670351 cites W2042649649 @default.
- W2093670351 cites W2046425777 @default.
- W2093670351 cites W2056016753 @default.
- W2093670351 cites W2057084723 @default.
- W2093670351 cites W2057954553 @default.
- W2093670351 cites W2061611811 @default.
- W2093670351 cites W2074391633 @default.
- W2093670351 cites W2082213193 @default.
- W2093670351 cites W2084890913 @default.
- W2093670351 cites W2093240010 @default.
- W2093670351 cites W2130687360 @default.
- W2093670351 cites W2142554308 @default.
- W2093670351 cites W3022208204 @default.
- W2093670351 cites W394967177 @default.
- W2093670351 doi "https://doi.org/10.1016/s0149-7634(87)80018-0" @default.
- W2093670351 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3684059" @default.
- W2093670351 hasPublicationYear "1987" @default.
- W2093670351 type Work @default.
- W2093670351 sameAs 2093670351 @default.
- W2093670351 citedByCount "15" @default.
- W2093670351 countsByYear W20936703512012 @default.
- W2093670351 countsByYear W20936703512013 @default.
- W2093670351 countsByYear W20936703512014 @default.
- W2093670351 crossrefType "journal-article" @default.
- W2093670351 hasAuthorship W2093670351A5047240384 @default.
- W2093670351 hasAuthorship W2093670351A5074071398 @default.
- W2093670351 hasAuthorship W2093670351A5086871900 @default.
- W2093670351 hasConcept C118552586 @default.
- W2093670351 hasConcept C151730666 @default.
- W2093670351 hasConcept C15744967 @default.
- W2093670351 hasConcept C185592680 @default.
- W2093670351 hasConcept C2776165026 @default.
- W2093670351 hasConcept C2776706248 @default.
- W2093670351 hasConcept C2777431362 @default.
- W2093670351 hasConcept C2777468819 @default.
- W2093670351 hasConcept C2778615406 @default.
- W2093670351 hasConcept C2779343474 @default.
- W2093670351 hasConcept C2779349466 @default.
- W2093670351 hasConcept C2779701627 @default.
- W2093670351 hasConcept C515207424 @default.
- W2093670351 hasConcept C55493867 @default.
- W2093670351 hasConcept C71924100 @default.
- W2093670351 hasConcept C86803240 @default.
- W2093670351 hasConcept C98274493 @default.
- W2093670351 hasConceptScore W2093670351C118552586 @default.
- W2093670351 hasConceptScore W2093670351C151730666 @default.
- W2093670351 hasConceptScore W2093670351C15744967 @default.
- W2093670351 hasConceptScore W2093670351C185592680 @default.
- W2093670351 hasConceptScore W2093670351C2776165026 @default.
- W2093670351 hasConceptScore W2093670351C2776706248 @default.
- W2093670351 hasConceptScore W2093670351C2777431362 @default.
- W2093670351 hasConceptScore W2093670351C2777468819 @default.
- W2093670351 hasConceptScore W2093670351C2778615406 @default.
- W2093670351 hasConceptScore W2093670351C2779343474 @default.
- W2093670351 hasConceptScore W2093670351C2779349466 @default.
- W2093670351 hasConceptScore W2093670351C2779701627 @default.
- W2093670351 hasConceptScore W2093670351C515207424 @default.
- W2093670351 hasConceptScore W2093670351C55493867 @default.
- W2093670351 hasConceptScore W2093670351C71924100 @default.
- W2093670351 hasConceptScore W2093670351C86803240 @default.
- W2093670351 hasConceptScore W2093670351C98274493 @default.
- W2093670351 hasIssue "3" @default.
- W2093670351 hasLocation W20936703511 @default.
- W2093670351 hasLocation W20936703512 @default.
- W2093670351 hasOpenAccess W2093670351 @default.
- W2093670351 hasPrimaryLocation W20936703511 @default.
- W2093670351 hasRelatedWork W1976713062 @default.
- W2093670351 hasRelatedWork W1985079385 @default.
- W2093670351 hasRelatedWork W1989005058 @default.
- W2093670351 hasRelatedWork W2014998047 @default.