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- W2093670419 abstract "A novel polypyridyl ligand 2-(4′-benzyloxyphenyl)imidazo[4,5-f][1,10]phenanthroline (BPIP) and its complex [Ru(bpy)2(BPIP)]2+ (1) (bpy = 2,2′-bipyridine) and (2) [Ru(phen)2(BPIP)]2+ (phen = 1,10-phenanthroline) have been synthesized and characterized by elemental analysis, electrospray mass spectra and 1H NMR. The DNA-binding properties of the two complexes were investigated by spectroscopic and viscosity measurements. The results suggest that both complexes bind to DNA via an intercalative mode. Both complexes can enantioselectively interact with calf thymus DNA (CT-DNA) in a way. The Λ enantiomer of complex 1 is slightly predominant for binding to CT-DNA to the Δ enantiomer. Under irradiation at 365 nm, both complexes have also been found to promote the photocleavage of plasmid pBR 322 DNA. Inhibitors studies suggest that singlet oxygen (1O2) and hydroxyl radical (OH) play a significant role in the cleavage mechanism for both complexes. Moreover, the DNA-binding and photocleavage properties of both complexes were compared with that of [Ru(bpy)2(BPIP)]2+ and [Ru(phen)2(BPIP)]2+. The experimental results indicate that methene group existence or not have a significant effect on the DNA-binding and cleavage mechanism of these complexes." @default.
- W2093670419 created "2016-06-24" @default.
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- W2093670419 date "2007-04-01" @default.
- W2093670419 modified "2023-09-29" @default.
- W2093670419 title "Ruthenium(II) mixed-ligand complex containing 2-(4′-benzyloxy-phenyl)imidazo[4,5-f][1,10]phenanthroline: Synthesis, DNA-binding and photocleavage studies" @default.
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- W2093670419 doi "https://doi.org/10.1016/j.jinorgbio.2006.12.016" @default.
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