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• W2093673971 endingPage "46" @default.
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• W2093673971 abstract "Caveolin-1 (Cav-1) is a membrane scaffolding protein, which functions to regulate intracellular compartmentalization of various signaling molecules. In the present studies, transgenic mice with a targeted disruption of the Cav-1 gene (Cav-1(-/-)) were used to assess the role of Cav-1 in acetaminophen-induced hepatotoxicity. Treatment of wild-type mice with acetaminophen (300 mg/kg) resulted in centrilobular hepatic necrosis and increases in serum transaminases. This was correlated with decreased expression of Cav-1 in the liver. Acetaminophen-induced hepatotoxicity was significantly attenuated in Cav-1(-/-) mice, an effect that was independent of acetaminophen metabolism. Acetaminophen administration resulted in increased hepatic expression of the oxidative stress marker, lipocalin 24p3, as well as hemeoxygenase-1, but decreased glutathione and superoxide dismutase-1; no differences were noted between the genotypes suggesting that reduced toxicity in Cav-1(-/-) mice is not due to alterations in antioxidant defense. In wild-type mice, acetaminophen increased mRNA expression of the pro-inflammatory cytokines, interleukin-1beta, and monocyte chemoattractant protein-1 (MCP-1), as well as cyclooxygenase-2, while 15-lipoxygenase (15-LOX), which generates anti-inflammatory lipoxins, decreased. Acetaminophen-induced changes in MCP-1 and 15-LOX expression were greater in Cav-1(-/-) mice. Although expression of tumor necrosis factor-alpha, a potent hepatocyte mitogen, was up-regulated in the liver of Cav-1(-/-) mice after acetaminophen, expression of proliferating cell nuclear antigen and survivin, markers of cellular proliferation, were delayed, which may reflect the reduced need for tissue repair. Taken together, these data demonstrate that Cav-1 plays a role in promoting inflammation and toxicity during the pathogenesis of acetaminophen-induced injury." @default.
• W2093673971 created "2016-06-24" @default.
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• W2093673971 date "2010-05-15" @default.
• W2093673971 modified "2023-10-06" @default.
• W2093673971 title "Potential role of caveolin-1 in acetaminophen-induced hepatotoxicity" @default.
• W2093673971 cites W1565915948 @default.
• W2093673971 cites W1662899239 @default.
• W2093673971 cites W170948591 @default.
• W2093673971 cites W1924535555 @default.
• W2093673971 cites W1932539832 @default.
• W2093673971 cites W1963812198 @default.
• W2093673971 cites W196831495 @default.
• W2093673971 cites W1973441276 @default.
• W2093673971 cites W1981972814 @default.
• W2093673971 cites W1984545745 @default.
• W2093673971 cites W1985226935 @default.
• W2093673971 cites W1991562066 @default.
• W2093673971 cites W1998201409 @default.
• W2093673971 cites W1999744363 @default.
• W2093673971 cites W2006286083 @default.
• W2093673971 cites W2009023679 @default.
• W2093673971 cites W2009162867 @default.
• W2093673971 cites W2014833145 @default.
• W2093673971 cites W2017354884 @default.
• W2093673971 cites W2026491809 @default.
• W2093673971 cites W2026611803 @default.
• W2093673971 cites W2028071396 @default.
• W2093673971 cites W2029282958 @default.
• W2093673971 cites W2029415268 @default.
• W2093673971 cites W2030698703 @default.
• W2093673971 cites W2041154904 @default.
• W2093673971 cites W2041841526 @default.
• W2093673971 cites W2043493252 @default.
• W2093673971 cites W2046440609 @default.
• W2093673971 cites W2049498039 @default.
• W2093673971 cites W2053891616 @default.
• W2093673971 cites W2055525658 @default.
• W2093673971 cites W2058846405 @default.
• W2093673971 cites W2059663496 @default.
• W2093673971 cites W2059663663 @default.
• W2093673971 cites W2061403078 @default.
• W2093673971 cites W2062398703 @default.
• W2093673971 cites W2064718100 @default.
• W2093673971 cites W2064759451 @default.
• W2093673971 cites W2066639032 @default.
• W2093673971 cites W2067175668 @default.
• W2093673971 cites W2076779593 @default.
• W2093673971 cites W2077318471 @default.
• W2093673971 cites W2079089488 @default.
• W2093673971 cites W2080050259 @default.
• W2093673971 cites W2081280036 @default.
• W2093673971 cites W2082870822 @default.
• W2093673971 cites W2083896648 @default.
• W2093673971 cites W2083968819 @default.
• W2093673971 cites W2084441247 @default.
• W2093673971 cites W2084973323 @default.
• W2093673971 cites W2085369362 @default.
• W2093673971 cites W2087696236 @default.
• W2093673971 cites W2088599644 @default.
• W2093673971 cites W2089757433 @default.
• W2093673971 cites W2093762655 @default.
• W2093673971 cites W2099742495 @default.
• W2093673971 cites W2111550054 @default.
• W2093673971 cites W2111833940 @default.
• W2093673971 cites W2112252275 @default.
• W2093673971 cites W2113685352 @default.
• W2093673971 cites W2118529933 @default.
• W2093673971 cites W2119417945 @default.
• W2093673971 cites W2123466828 @default.
• W2093673971 cites W2123869725 @default.
• W2093673971 cites W2138150621 @default.
• W2093673971 cites W2139542190 @default.
• W2093673971 cites W2148102136 @default.
• W2093673971 cites W2152462171 @default.
• W2093673971 cites W2153334141 @default.
• W2093673971 cites W2153496829 @default.
• W2093673971 cites W2159391262 @default.
• W2093673971 cites W2161959295 @default.
• W2093673971 cites W2164578997 @default.
• W2093673971 cites W2164693286 @default.
• W2093673971 cites W2169296803 @default.
• W2093673971 cites W2401940175 @default.
• W2093673971 cites W2504901492 @default.
• W2093673971 cites W300087980 @default.
• W2093673971 cites W608898351 @default.
• W2093673971 cites W92884246 @default.
• W2093673971 doi "https://doi.org/10.1016/j.taap.2010.01.008" @default.
• W2093673971 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2862893" @default.
• W2093673971 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20100502" @default.

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