FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2093674575> ?p ?o ?g. }

• W2093674575 endingPage "1222" @default.
• W2093674575 startingPage "1216" @default.
• W2093674575 abstract "Atrophy of skeletal muscle is due to a depression in protein synthesis and an increase in degradation. Studies in vitro have suggested that activation of the dsRNA-dependent protein kinase (PKR) may be responsible for these changes in protein synthesis and degradation. In order to evaluate whether this is also applicable to cancer cachexia the action of a PKR inhibitor on the development of cachexia has been studied in mice bearing the MAC16 tumour. Treatment of animals with the PKR inhibitor (5 mg kg(-1)) significantly reduced levels of phospho-PKR in muscle down to that found in non-tumour-bearing mice, and effectively attenuated the depression of body weight, with increased muscle mass, and also inhibited tumour growth. There was an increase in protein synthesis in skeletal muscle, which paralleled a decrease in eukaryotic initiation factor 2alpha phosphorylation. Protein degradation rates in skeletal muscle were also significantly decreased, as was proteasome activity levels and expression. Myosin levels were increased up to values found in non-tumour-bearing animals. Proteasome expression correlated with a decreased nuclear accumulation of nuclear factor-kappaB (NF-kappaB). The PKR inhibitor also significantly inhibited tumour growth, although this appeared to be a separate event from the effect on muscle wasting. These results suggest that inhibition of the autophosphorylation of PKR may represent an appropriate target for the attenuation of muscle atrophy in cancer cachexia." @default.
• W2093674575 created "2016-06-24" @default.
• W2093674575 creator A5010015013 @default.
• W2093674575 creator A5046076101 @default.
• W2093674575 creator A5070070958 @default.
• W2093674575 date "2007-03-27" @default.
• W2093674575 modified "2023-10-16" @default.
• W2093674575 title "Attenuation of muscle atrophy in a murine model of cachexia by inhibition of the dsRNA-dependent protein kinase" @default.
• W2093674575 cites W1527390792 @default.
• W2093674575 cites W1551930510 @default.
• W2093674575 cites W1968862012 @default.
• W2093674575 cites W1974099977 @default.
• W2093674575 cites W1984364760 @default.
• W2093674575 cites W1984673950 @default.
• W2093674575 cites W1985534077 @default.
• W2093674575 cites W1999506801 @default.
• W2093674575 cites W2007456673 @default.
• W2093674575 cites W2014867066 @default.
• W2093674575 cites W2035498285 @default.
• W2093674575 cites W2039111148 @default.
• W2093674575 cites W2046289475 @default.
• W2093674575 cites W2048227382 @default.
• W2093674575 cites W2051994734 @default.
• W2093674575 cites W2060511918 @default.
• W2093674575 cites W2076277955 @default.
• W2093674575 cites W2077218757 @default.
• W2093674575 cites W2089033636 @default.
• W2093674575 cites W2094646101 @default.
• W2093674575 cites W2096786196 @default.
• W2093674575 cites W2136395092 @default.
• W2093674575 cites W2142599230 @default.
• W2093674575 cites W2142712951 @default.
• W2093674575 cites W2151856174 @default.
• W2093674575 cites W2155685150 @default.
• W2093674575 cites W2161832141 @default.
• W2093674575 cites W2274283551 @default.
• W2093674575 doi "https://doi.org/10.1038/sj.bjc.6603704" @default.
• W2093674575 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2360141" @default.
• W2093674575 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17387345" @default.
• W2093674575 hasPublicationYear "2007" @default.
• W2093674575 type Work @default.
• W2093674575 sameAs 2093674575 @default.
• W2093674575 citedByCount "41" @default.
• W2093674575 countsByYear W20936745752012 @default.
• W2093674575 countsByYear W20936745752013 @default.
• W2093674575 countsByYear W20936745752014 @default.
• W2093674575 countsByYear W20936745752015 @default.
• W2093674575 countsByYear W20936745752016 @default.
• W2093674575 countsByYear W20936745752017 @default.
• W2093674575 countsByYear W20936745752018 @default.
• W2093674575 countsByYear W20936745752019 @default.
• W2093674575 countsByYear W20936745752020 @default.
• W2093674575 countsByYear W20936745752021 @default.
• W2093674575 countsByYear W20936745752023 @default.
• W2093674575 crossrefType "journal-article" @default.
• W2093674575 hasAuthorship W2093674575A5010015013 @default.
• W2093674575 hasAuthorship W2093674575A5046076101 @default.
• W2093674575 hasAuthorship W2093674575A5070070958 @default.
• W2093674575 hasBestOaLocation W20936745751 @default.
• W2093674575 hasConcept C121608353 @default.
• W2093674575 hasConcept C126322002 @default.
• W2093674575 hasConcept C134018914 @default.
• W2093674575 hasConcept C150109051 @default.
• W2093674575 hasConcept C161238802 @default.
• W2093674575 hasConcept C167414201 @default.
• W2093674575 hasConcept C184235292 @default.
• W2093674575 hasConcept C207200792 @default.
• W2093674575 hasConcept C2776214593 @default.
• W2093674575 hasConcept C2776263037 @default.
• W2093674575 hasConcept C2777488582 @default.
• W2093674575 hasConcept C2777704314 @default.
• W2093674575 hasConcept C2779764123 @default.
• W2093674575 hasConcept C2779959927 @default.
• W2093674575 hasConcept C2781172350 @default.
• W2093674575 hasConcept C2992195973 @default.
• W2093674575 hasConcept C71924100 @default.
• W2093674575 hasConcept C86803240 @default.
• W2093674575 hasConcept C90934575 @default.
• W2093674575 hasConcept C95444343 @default.
• W2093674575 hasConcept C97029542 @default.
• W2093674575 hasConceptScore W2093674575C121608353 @default.
• W2093674575 hasConceptScore W2093674575C126322002 @default.
• W2093674575 hasConceptScore W2093674575C134018914 @default.
• W2093674575 hasConceptScore W2093674575C150109051 @default.
• W2093674575 hasConceptScore W2093674575C161238802 @default.
• W2093674575 hasConceptScore W2093674575C167414201 @default.
• W2093674575 hasConceptScore W2093674575C184235292 @default.
• W2093674575 hasConceptScore W2093674575C207200792 @default.
• W2093674575 hasConceptScore W2093674575C2776214593 @default.
• W2093674575 hasConceptScore W2093674575C2776263037 @default.
• W2093674575 hasConceptScore W2093674575C2777488582 @default.
• W2093674575 hasConceptScore W2093674575C2777704314 @default.
• W2093674575 hasConceptScore W2093674575C2779764123 @default.
• W2093674575 hasConceptScore W2093674575C2779959927 @default.
• W2093674575 hasConceptScore W2093674575C2781172350 @default.
• W2093674575 hasConceptScore W2093674575C2992195973 @default.
• W2093674575 hasConceptScore W2093674575C71924100 @default.
• W2093674575 hasConceptScore W2093674575C86803240 @default.

• next