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- W2093676288 abstract "Noradrenaline (1–10 μM) inhibited Ca 2+ ‐induced insulin secretion from electrically permeabilised islets of Langerhans with an efficacy similar to that for inhibition of glucose‐induced insulin secretion from intact islets. The inhibition of insulin secretion from permeabilised islets was blocked by the α 2 ‐adrenoreceptor antagonist, yohimbine. Adenosine 3′,5′‐cyclic monophosphate (cAMP) did not relieve the noradrenaline inhibition of Ca 2+ ‐induced secretion from the permeabilised islets, although noradrenaline did not affect the secretory responses to cAMP at substimulatory (50 nM) concentrations of Ca 2+ . These results suggest that catecholamines do not inhibit insulin secretion solely by reducing B‐cell adenylate cyclase activity, and imply that one site of action of noradrenaline is at a late stage in the secretory process." @default.
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- W2093676288 date "1987-07-13" @default.
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- W2093676288 title "Catecholamine inhibition of Ca<sup>2+</sup>-induced insulin secretion from electrically permeabilised islets of Langerhans" @default.
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- W2093676288 doi "https://doi.org/10.1016/0014-5793(87)81206-1" @default.
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