Matches in SemOpenAlex for { <https://semopenalex.org/work/W2093680968> ?p ?o ?g. }
- W2093680968 endingPage "1472" @default.
- W2093680968 startingPage "1459" @default.
- W2093680968 abstract "Many host–parasite interactions are regulated in part by the programmed cell death of host cells or the parasite. Here we review evidence suggesting that programmed cell death occurs during the early stages of the development of the malaria parasite in its vector. Zygotes and ookinetes of Plasmodium berghei have been shown to die by programmed cell death (apoptosis) in the midgut lumen of the vector Anopheles stephensi, or whilst developing in vitro. Several morphological markers, indicative of apoptosis, are described and evidence for the involvement of a biochemical pathway involving cysteine proteases discussed in relationship to other protozoan parasites. Malaria infection induces apoptosis in the cells of two mosquito tissues, the midgut and the follicular epithelium. Observations on cell death in both these tissues are reviewed including the role of caspases as effector molecules and the rescue of resorbing follicles resulting from inhibition of caspases. Putative signal molecules that might induce parasite and vector apoptosis are suggested including nitric oxide, reactive nitrogen intermediates, oxygen radicals and endocrine balances. Finally, we suggest that programmed cell death may play a critical role in regulation of infection by the parasite and the host, and contribute to the success or not of parasite establishment and host survival." @default.
- W2093680968 created "2016-06-24" @default.
- W2093680968 creator A5057408197 @default.
- W2093680968 creator A5064359359 @default.
- W2093680968 date "2004-12-01" @default.
- W2093680968 modified "2023-10-03" @default.
- W2093680968 title "The role of programmed cell death in Plasmodium–mosquito interactions" @default.
- W2093680968 cites W1519120937 @default.
- W2093680968 cites W1588042586 @default.
- W2093680968 cites W1589415602 @default.
- W2093680968 cites W1605273522 @default.
- W2093680968 cites W1745634660 @default.
- W2093680968 cites W1782545213 @default.
- W2093680968 cites W1819638116 @default.
- W2093680968 cites W1964297184 @default.
- W2093680968 cites W1964822872 @default.
- W2093680968 cites W1965928916 @default.
- W2093680968 cites W1968044713 @default.
- W2093680968 cites W1970448853 @default.
- W2093680968 cites W1973349116 @default.
- W2093680968 cites W1973722221 @default.
- W2093680968 cites W1978833177 @default.
- W2093680968 cites W1980037437 @default.
- W2093680968 cites W1980414703 @default.
- W2093680968 cites W1982037867 @default.
- W2093680968 cites W1983774663 @default.
- W2093680968 cites W1986918666 @default.
- W2093680968 cites W1987546203 @default.
- W2093680968 cites W1987979056 @default.
- W2093680968 cites W2004051711 @default.
- W2093680968 cites W2004138269 @default.
- W2093680968 cites W2005728706 @default.
- W2093680968 cites W2008186920 @default.
- W2093680968 cites W2008275506 @default.
- W2093680968 cites W2009947869 @default.
- W2093680968 cites W2016875675 @default.
- W2093680968 cites W2017581149 @default.
- W2093680968 cites W2019016430 @default.
- W2093680968 cites W2019211309 @default.
- W2093680968 cites W2019851585 @default.
- W2093680968 cites W2020796977 @default.
- W2093680968 cites W2021974175 @default.
- W2093680968 cites W2022745094 @default.
- W2093680968 cites W2026513070 @default.
- W2093680968 cites W2026617683 @default.
- W2093680968 cites W2030956146 @default.
- W2093680968 cites W2032128070 @default.
- W2093680968 cites W2033596981 @default.
- W2093680968 cites W2033856139 @default.
- W2093680968 cites W2036788806 @default.
- W2093680968 cites W2037265145 @default.
- W2093680968 cites W2038644790 @default.
- W2093680968 cites W2040004663 @default.
- W2093680968 cites W2041011266 @default.
- W2093680968 cites W2043659101 @default.
- W2093680968 cites W2046263258 @default.
- W2093680968 cites W2046578035 @default.
- W2093680968 cites W2048673047 @default.
- W2093680968 cites W2052853635 @default.
- W2093680968 cites W2056426949 @default.
- W2093680968 cites W2060102739 @default.
- W2093680968 cites W2061497413 @default.
- W2093680968 cites W2061708393 @default.
- W2093680968 cites W2069107030 @default.
- W2093680968 cites W2069252806 @default.
- W2093680968 cites W2072090415 @default.
- W2093680968 cites W2075011887 @default.
- W2093680968 cites W2079223597 @default.
- W2093680968 cites W2080886415 @default.
- W2093680968 cites W2082376575 @default.
- W2093680968 cites W2083906562 @default.
- W2093680968 cites W2085212583 @default.
- W2093680968 cites W2089550565 @default.
- W2093680968 cites W2090554701 @default.
- W2093680968 cites W2093765409 @default.
- W2093680968 cites W2097904707 @default.
- W2093680968 cites W2098429428 @default.
- W2093680968 cites W2099443046 @default.
- W2093680968 cites W2104480040 @default.
- W2093680968 cites W2113831354 @default.
- W2093680968 cites W2121702473 @default.
- W2093680968 cites W2122826329 @default.
- W2093680968 cites W2125536365 @default.
- W2093680968 cites W2125912444 @default.
- W2093680968 cites W2130280297 @default.
- W2093680968 cites W2131462203 @default.
- W2093680968 cites W2132411546 @default.
- W2093680968 cites W2133821029 @default.
- W2093680968 cites W2143405339 @default.
- W2093680968 cites W2154554320 @default.
- W2093680968 cites W2155180789 @default.
- W2093680968 cites W2157708069 @default.
- W2093680968 cites W2159132498 @default.
- W2093680968 cites W2162221985 @default.
- W2093680968 cites W2163771974 @default.
- W2093680968 cites W2165321783 @default.
- W2093680968 cites W2169788635 @default.
- W2093680968 cites W2176314571 @default.