FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2093682762> ?p ?o ?g. }

• W2093682762 endingPage "S47" @default.
• W2093682762 startingPage "S41" @default.
• W2093682762 abstract "Some environmental and genetic factors play important roles in etiopathogenesis of type 1 or insulin-dependent diabetes mellitus (IDDM). HLA genes, the IDDM1 locus located the human chromosome 6, were found to be associated with insulin-dependent diabetes mellitus. However, the incidence of IDDM varied greatly among various populations. To evaluate the pathogenetic factors contributing to the development of IDDM in Taiwan, HLA typing was performed in a group of IDDM unrelated individuals and IDDM pedigrees along with the normal controls from the northern Taiwan. DNA genotypes of class II HLA were done by polymerase-chain-reaction based oligotyping techniques. We confirmed that class II HLA genes were significantly associated with IDDM in Taiwan. To study detailed molecular structure of class II HLA molecules and disease association, we examined several amino acid residues on DQalpha and DQbeta chains and the molecular mechanisms to explain the heterozygotic effect of the DR3/DR4 and DR3/DR9 in the Chinese population. Linkage analysis in our pedigrees confirmed the association between HLA and IDDM in population association studies. Among the several class II alleles, a closer segregation of HLA-DQB1*0401 to the affected persons might suggest that HLA-DQB1*0401 itself or an allele closely linked to the DQB1 locus was the IDDM-predisposing allele in Taiwanese. For IDDM2 (INS) region, association with IDDM was not found due to that more than 90% of the population carried class I alleles. In our collection of IDDM, we found few cases (2.4%) carried mitochondrial DNA mutation. Our studies in Taiwanese confirm a multigenetic nature for IDDM." @default.
• W2093682762 created "2016-06-24" @default.
• W2093682762 creator A5033802039 @default.
• W2093682762 creator A5042628573 @default.
• W2093682762 creator A5049674356 @default.
• W2093682762 creator A5075971265 @default.
• W2093682762 creator A5079569153 @default.
• W2093682762 date "2000-10-01" @default.
• W2093682762 modified "2023-09-27" @default.
• W2093682762 title "Genetic epidemiology of type 1 diabetes mellitus in Taiwan" @default.
• W2093682762 cites W161846367 @default.
• W2093682762 cites W1973189927 @default.
• W2093682762 cites W1976613945 @default.
• W2093682762 cites W1979783059 @default.
• W2093682762 cites W1981490811 @default.
• W2093682762 cites W1989055205 @default.
• W2093682762 cites W1990177394 @default.
• W2093682762 cites W1992678028 @default.
• W2093682762 cites W1995483481 @default.
• W2093682762 cites W1996412706 @default.
• W2093682762 cites W1997467112 @default.
• W2093682762 cites W2003680855 @default.
• W2093682762 cites W2004202345 @default.
• W2093682762 cites W2014466456 @default.
• W2093682762 cites W2016461041 @default.
• W2093682762 cites W2031503440 @default.
• W2093682762 cites W2039396900 @default.
• W2093682762 cites W2040709020 @default.
• W2093682762 cites W2040994708 @default.
• W2093682762 cites W2041605771 @default.
• W2093682762 cites W2042893629 @default.
• W2093682762 cites W2056139065 @default.
• W2093682762 cites W2063712097 @default.
• W2093682762 cites W2065114142 @default.
• W2093682762 cites W2068321755 @default.
• W2093682762 cites W2083472337 @default.
• W2093682762 cites W2087480891 @default.
• W2093682762 cites W2094737836 @default.
• W2093682762 cites W2098221665 @default.
• W2093682762 cites W2099245432 @default.
• W2093682762 cites W2099862054 @default.
• W2093682762 cites W2106869807 @default.
• W2093682762 cites W2112545478 @default.
• W2093682762 cites W2114612730 @default.
• W2093682762 cites W2114904158 @default.
• W2093682762 cites W2122196116 @default.
• W2093682762 cites W2129754316 @default.
• W2093682762 cites W2147206145 @default.
• W2093682762 cites W2147334375 @default.
• W2093682762 cites W2314574316 @default.
• W2093682762 cites W2323741979 @default.
• W2093682762 cites W2326904657 @default.
• W2093682762 cites W2335350296 @default.
• W2093682762 cites W2408777117 @default.
• W2093682762 cites W2409951002 @default.
• W2093682762 cites W2411791650 @default.
• W2093682762 cites W2414755725 @default.
• W2093682762 cites W2416340380 @default.
• W2093682762 cites W2442400994 @default.
• W2093682762 cites W342493743 @default.
• W2093682762 cites W87545951 @default.
• W2093682762 cites W2042927367 @default.
• W2093682762 doi "https://doi.org/10.1016/s0168-8227(00)00178-9" @default.
• W2093682762 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11024583" @default.
• W2093682762 hasPublicationYear "2000" @default.
• W2093682762 type Work @default.
• W2093682762 sameAs 2093682762 @default.
• W2093682762 citedByCount "4" @default.
• W2093682762 countsByYear W20936827622014 @default.
• W2093682762 crossrefType "journal-article" @default.
• W2093682762 hasAuthorship W2093682762A5033802039 @default.
• W2093682762 hasAuthorship W2093682762A5042628573 @default.
• W2093682762 hasAuthorship W2093682762A5049674356 @default.
• W2093682762 hasAuthorship W2093682762A5075971265 @default.
• W2093682762 hasAuthorship W2093682762A5079569153 @default.
• W2093682762 hasConcept C104317684 @default.
• W2093682762 hasConcept C134018914 @default.
• W2093682762 hasConcept C135763542 @default.
• W2093682762 hasConcept C142870003 @default.
• W2093682762 hasConcept C147483822 @default.
• W2093682762 hasConcept C180754005 @default.
• W2093682762 hasConcept C188280979 @default.
• W2093682762 hasConcept C197754878 @default.
• W2093682762 hasConcept C22593422 @default.
• W2093682762 hasConcept C2779910283 @default.
• W2093682762 hasConcept C2908647359 @default.
• W2093682762 hasConcept C54355233 @default.
• W2093682762 hasConcept C555293320 @default.
• W2093682762 hasConcept C71924100 @default.
• W2093682762 hasConcept C84597430 @default.
• W2093682762 hasConcept C86803240 @default.
• W2093682762 hasConcept C99454951 @default.
• W2093682762 hasConceptScore W2093682762C104317684 @default.
• W2093682762 hasConceptScore W2093682762C134018914 @default.
• W2093682762 hasConceptScore W2093682762C135763542 @default.
• W2093682762 hasConceptScore W2093682762C142870003 @default.
• W2093682762 hasConceptScore W2093682762C147483822 @default.
• W2093682762 hasConceptScore W2093682762C180754005 @default.

• next