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- W2093685198 abstract "By employing as a probe the new compound, N,N-diethyl-2-[(4-phenyl-methyl)-phenoxy]-ethanamine X HC1 (N,N-DPPE), which preferentially binds the anti-estrogen binding site, it is demonstrated that this site appears to contribute to the growth inhibitory action of tamoxifen on MCF-7 human breast cancer cells, even at lower concentrations of this anti-estrogen (1 X 10(-7) M to 1 X 10(-6) M) at which the major effect is clearly mediated via estrogen receptor. The combination of N,N-DPPE and tamoxifen is additive and this effect is not abolished by 17 beta-estradiol. This suggests that the anti-estrogen binding site is not simply a passive reservoir for binding tamoxifen, but may itself mediate the cytotoxic effects of specific ligands." @default.
- W2093685198 created "2016-06-24" @default.
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- W2093685198 date "1984-10-01" @default.
- W2093685198 modified "2023-09-26" @default.
- W2093685198 title "A diphenylmethane derivative selective for the anti-estrogen binding site may help define its biological role" @default.
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- W2093685198 doi "https://doi.org/10.1016/0006-291x(84)90943-4" @default.
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