FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2093695488> ?p ?o ?g. }

• W2093695488 endingPage "244" @default.
• W2093695488 startingPage "235" @default.
• W2093695488 abstract "Hyperthyroidism is associated with altered growth hormone (GH) secretion. Many patients with thyroid dysfunction experience several poorly described complications such as symptoms and signs also seen in patients with growth hormone deficiency (GHD). We have therefore prospectively evaluated a possible relationship between the thyroid function, body composition, leptin levels and insulin-like growth factor (IGF) related peptides in patients with Graves' disease. DESIGN, PATIENTS, AND MEASUREMENTS: In a prospective group of 24 fasting female patients with Graves' disease (mean age (CI 95%): 40 years (33-47)), we measured serum thyroxine, triiodothyronine, thyrotropine (TSH), TSH receptor antibodies, anti-thyroid peroxidase, leptin, body composition, body mass index (BMI) and IGF-related peptides at diagnosis and after 12 months of treatment with thiamazol (ATD).In thyrotoxic patients IGF-I plus IGF-II correlated positively with IGFBP-3 at baseline (r = 0.90, p < 0.1 x 10(16)) and after 12 months follow-up (r = 0.87, p < 0.1 x 10(-16)). In the thyrotoxic state total IGF-I, IGF-II, IGF binding protein 3 (IGFBP-3) and acid-labile subunit (ALS) but not free IGF-I decreased significantly from 223 microg/L (189-260) (mean (CI 95%), 877 microg/L (801-953), 4165 microg/L (3772-4577) and 22 mg/L (18-26)) to 198 microg/L (172-226), 788 microg/L (711-865), 3431 microg/L (3135-3741) and 19 mg/L (16-26) (p <0.006), respectively, after 12 months of ATD despite an increase in BMI from 22 (21-23) to 23 kg/m(2) (22-25) (p < 0.0004) but no significant changes in leptin.The complex IGF systems seemed intact in thyrotoxic patients but change in body composition and the regulation of leptin and insulin secretion during treatment of autoimmune thyroid disease influence IGF-related peptides leaving the patient in a state somewhat similar to partial GHD, but the mechanism behind these alterations remains unclear." @default.
• W2093695488 created "2016-06-24" @default.
• W2093695488 creator A5018818724 @default.
• W2093695488 creator A5045917807 @default.
• W2093695488 creator A5065850266 @default.
• W2093695488 creator A5085122960 @default.
• W2093695488 date "2004-06-01" @default.
• W2093695488 modified "2023-09-30" @default.
• W2093695488 title "The insulin-like growth axis in patients with autoimmune thyrotoxicosis: effect of antithyroid drug treatment" @default.
• W2093695488 cites W1513376696 @default.
• W2093695488 cites W1561443084 @default.
• W2093695488 cites W1575263278 @default.
• W2093695488 cites W1970373283 @default.
• W2093695488 cites W1976575003 @default.
• W2093695488 cites W1986938381 @default.
• W2093695488 cites W1992829214 @default.
• W2093695488 cites W1996713062 @default.
• W2093695488 cites W2007265160 @default.
• W2093695488 cites W2007272731 @default.
• W2093695488 cites W2011367510 @default.
• W2093695488 cites W2014843590 @default.
• W2093695488 cites W2022698715 @default.
• W2093695488 cites W2024109244 @default.
• W2093695488 cites W2024729268 @default.
• W2093695488 cites W2031639163 @default.
• W2093695488 cites W2042574132 @default.
• W2093695488 cites W2050959330 @default.
• W2093695488 cites W2054720570 @default.
• W2093695488 cites W2055445517 @default.
• W2093695488 cites W2056100153 @default.
• W2093695488 cites W2060682066 @default.
• W2093695488 cites W2062957914 @default.
• W2093695488 cites W2067947429 @default.
• W2093695488 cites W2068952091 @default.
• W2093695488 cites W2071648601 @default.
• W2093695488 cites W2074446816 @default.
• W2093695488 cites W2078427368 @default.
• W2093695488 cites W2080283914 @default.
• W2093695488 cites W2081096579 @default.
• W2093695488 cites W2083792240 @default.
• W2093695488 cites W2092498253 @default.
• W2093695488 cites W2092966764 @default.
• W2093695488 cites W2093112501 @default.
• W2093695488 cites W2095235597 @default.
• W2093695488 cites W2097327197 @default.
• W2093695488 cites W2097789382 @default.
• W2093695488 cites W2098908401 @default.
• W2093695488 cites W2099621175 @default.
• W2093695488 cites W2101397602 @default.
• W2093695488 cites W2104012044 @default.
• W2093695488 cites W2105429765 @default.
• W2093695488 cites W2117370487 @default.
• W2093695488 cites W2120217103 @default.
• W2093695488 cites W2120939767 @default.
• W2093695488 cites W2122110999 @default.
• W2093695488 cites W2131042063 @default.
• W2093695488 cites W2149440651 @default.
• W2093695488 cites W2157822195 @default.
• W2093695488 cites W2166708656 @default.
• W2093695488 cites W2167628665 @default.
• W2093695488 cites W2171427547 @default.
• W2093695488 cites W2176506025 @default.
• W2093695488 cites W2262457072 @default.
• W2093695488 cites W2323995116 @default.
• W2093695488 cites W2442929901 @default.
• W2093695488 cites W4231290525 @default.
• W2093695488 cites W4235612129 @default.
• W2093695488 cites W4236757670 @default.
• W2093695488 cites W4236965423 @default.
• W2093695488 cites W4237742941 @default.
• W2093695488 cites W4238487939 @default.
• W2093695488 cites W4245304897 @default.
• W2093695488 cites W4245554810 @default.
• W2093695488 cites W4248209523 @default.
• W2093695488 cites W4248547783 @default.
• W2093695488 cites W4249116997 @default.
• W2093695488 cites W4249837375 @default.
• W2093695488 cites W4254613443 @default.
• W2093695488 doi "https://doi.org/10.1016/j.ghir.2003.12.015" @default.
• W2093695488 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15125885" @default.
• W2093695488 hasPublicationYear "2004" @default.
• W2093695488 type Work @default.
• W2093695488 sameAs 2093695488 @default.
• W2093695488 citedByCount "10" @default.
• W2093695488 countsByYear W20936954882015 @default.
• W2093695488 countsByYear W20936954882017 @default.
• W2093695488 countsByYear W20936954882018 @default.
• W2093695488 crossrefType "journal-article" @default.
• W2093695488 hasAuthorship W2093695488A5018818724 @default.
• W2093695488 hasAuthorship W2093695488A5045917807 @default.
• W2093695488 hasAuthorship W2093695488A5065850266 @default.
• W2093695488 hasAuthorship W2093695488A5085122960 @default.
• W2093695488 hasConcept C126322002 @default.
• W2093695488 hasConcept C134018914 @default.
• W2093695488 hasConcept C180650514 @default.
• W2093695488 hasConcept C188816634 @default.
• W2093695488 hasConcept C2776652619 @default.
• W2093695488 hasConcept C2778288131 @default.

• next