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• W2093701669 abstract "Purpose/Objective(s)Reoxygenation has a deep impact on tumor control in fractionated radiation therapy. With the improvements in radiation therapy technology including IMRT and SRT, it has become much more important to understand the reoxygenation phenomenon clearly. Pulsed electron paramagnetic resonance imaging (EPRI) is a novel imaging method to directly monitor the pO2 in a tumor on a quantitative basis. The purpose of this work was to assess the usefulness of EPRI for reoxygenation imaging in radiation therapy using murine models of human cancer.Materials/MethodsHT29 and HCT 116 solid tumors were formed by injecting 1 × 106 cells s.c. into the right hind legs of nude mice. The experiments were started when tumors grew to approximately 800 mm3. It took 12 min to obtain a data set for a 3D pO2 image. The spatial resolution was 1.8 mm. EPRI was performed before and at 30 minutes, 60 minutes, and 24 hours after 3 Gy irradiation in HT29 and HCT 116 tumors (n = 6 per time point). We also analyzed how irradiation dose affected the reoxygenation, and EPR imaging was done before and at 30 minutes, 60 minutes, 2 hours, 18 hours, 24 hours, and 30 hours after 3 Gy, 10 Gy, and 20 Gy irradiation in HT29 tumors (n = 6 per time point). We assessed the correlation between the hypoxic fraction (< 10 mmHg) measured by the pO2 imaging and immunohistochemical findings with pimonidazole staining. All pO2 results were expressed as the average ± SEM (mmHg).ResultsMedian pO2 of HT29 tumors was 15.9 ± 1.0 before irradiation, 15.4 ± 1.1 at 30 minutes after 3 Gy irradiation, 14.0 ± 1.0 at 60 minutes, and 15.4 ± 0.6 at 24 hours. In HCT116 tumors, it was 14.9 ± 0.9 before irradiation, 13.4 ± 0.9 at 30 minutes after 3 Gy irradiation, 9.1 ± 1.5 at 60 minutes, and 12.0 ± 1.5 at 24 hours. Median pO2 of HT29 tumors was 15.9 ± 1.0 before irradiation, After 3 Gy, 10 Gy, and 20 Gy irradiation, it was, respectively, 15.4 ± 1.1, 14.1 ± 0.3, and 12.7 ± 1.5 at 30 minutes, 14.0 ± 1.0, 13.6 ± 1.0, and 11.8 ± 1.3 at 60 minutes, 15.3 ± 0.6, 13.7 ± 0.5, and 11.4 ± 0.8 at 2 hours, 15.2 ± 0.7, 13.6 ± 1.0, and 13.7 ± 0.5 at 18 hours, 15.4 ± 0.6, 13.6 ± 0.8, and 13.9 ± 0.6 at 24 hours, and 15.2 ± 0.7, 13.8 ± 0.3, and 13.7 ± 0.5 at 30 hours. Immunohistochemical analysis suggested that the hypoxic fraction measured by the pO2 imaging correlated with the pimonidazole density in both HT29 and HCT116 tumors.ConclusionsThis study demonstrated the phenomenon of reoxygenation after irradiation in HT29 and HCT116 tumors by using EPR pO2 imaging. Degree of pO2 decrease and time to recover from pO2 decrease after irradiation depended on irradiation dose. This result indicated the possibility and importance of a new radiation therapy concept such as reoxygenation-based radiation therapy. Purpose/Objective(s)Reoxygenation has a deep impact on tumor control in fractionated radiation therapy. With the improvements in radiation therapy technology including IMRT and SRT, it has become much more important to understand the reoxygenation phenomenon clearly. Pulsed electron paramagnetic resonance imaging (EPRI) is a novel imaging method to directly monitor the pO2 in a tumor on a quantitative basis. The purpose of this work was to assess the usefulness of EPRI for reoxygenation imaging in radiation therapy using murine models of human cancer. Reoxygenation has a deep impact on tumor control in fractionated radiation therapy. With the improvements in radiation therapy technology including IMRT and SRT, it has become much more important to understand the reoxygenation phenomenon clearly. Pulsed electron paramagnetic resonance imaging (EPRI) is a novel imaging method to directly monitor the pO2 in a tumor on a quantitative basis. The purpose of this work was to assess the usefulness of EPRI for reoxygenation imaging in radiation therapy using murine models of human cancer. Materials/MethodsHT29 and HCT 116 solid tumors were formed by injecting 1 × 106 cells s.c. into the right hind legs of nude mice. The experiments were started when tumors grew to approximately 800 mm3. It took 12 min to obtain a data set for a 3D pO2 image. The spatial resolution was 1.8 mm. EPRI was performed before and at 30 minutes, 60 minutes, and 24 hours after 3 Gy irradiation in HT29 and HCT 116 tumors (n = 6 per time point). We also analyzed how irradiation dose affected the reoxygenation, and EPR imaging was done before and at 30 minutes, 60 minutes, 2 hours, 18 hours, 24 hours, and 30 hours after 3 Gy, 10 Gy, and 20 Gy irradiation in HT29 tumors (n = 6 per time point). We assessed the correlation between the hypoxic fraction (< 10 mmHg) measured by the pO2 imaging and immunohistochemical findings with pimonidazole staining. All pO2 results were expressed as the average ± SEM (mmHg). HT29 and HCT 116 solid tumors were formed by injecting 1 × 106 cells s.c. into the right hind legs of nude mice. The experiments were started when tumors grew to approximately 800 mm3. It took 12 min to obtain a data set for a 3D pO2 image. The spatial resolution was 1.8 mm. EPRI was performed before and at 30 minutes, 60 minutes, and 24 hours after 3 Gy irradiation in HT29 and HCT 116 tumors (n = 6 per time point). We also analyzed how irradiation dose affected the reoxygenation, and EPR imaging was done before and at 30 minutes, 60 minutes, 2 hours, 18 hours, 24 hours, and 30 hours after 3 Gy, 10 Gy, and 20 Gy irradiation in HT29 tumors (n = 6 per time point). We assessed the correlation between the hypoxic fraction (< 10 mmHg) measured by the pO2 imaging and immunohistochemical findings with pimonidazole staining. All pO2 results were expressed as the average ± SEM (mmHg). ResultsMedian pO2 of HT29 tumors was 15.9 ± 1.0 before irradiation, 15.4 ± 1.1 at 30 minutes after 3 Gy irradiation, 14.0 ± 1.0 at 60 minutes, and 15.4 ± 0.6 at 24 hours. In HCT116 tumors, it was 14.9 ± 0.9 before irradiation, 13.4 ± 0.9 at 30 minutes after 3 Gy irradiation, 9.1 ± 1.5 at 60 minutes, and 12.0 ± 1.5 at 24 hours. Median pO2 of HT29 tumors was 15.9 ± 1.0 before irradiation, After 3 Gy, 10 Gy, and 20 Gy irradiation, it was, respectively, 15.4 ± 1.1, 14.1 ± 0.3, and 12.7 ± 1.5 at 30 minutes, 14.0 ± 1.0, 13.6 ± 1.0, and 11.8 ± 1.3 at 60 minutes, 15.3 ± 0.6, 13.7 ± 0.5, and 11.4 ± 0.8 at 2 hours, 15.2 ± 0.7, 13.6 ± 1.0, and 13.7 ± 0.5 at 18 hours, 15.4 ± 0.6, 13.6 ± 0.8, and 13.9 ± 0.6 at 24 hours, and 15.2 ± 0.7, 13.8 ± 0.3, and 13.7 ± 0.5 at 30 hours. Immunohistochemical analysis suggested that the hypoxic fraction measured by the pO2 imaging correlated with the pimonidazole density in both HT29 and HCT116 tumors. Median pO2 of HT29 tumors was 15.9 ± 1.0 before irradiation, 15.4 ± 1.1 at 30 minutes after 3 Gy irradiation, 14.0 ± 1.0 at 60 minutes, and 15.4 ± 0.6 at 24 hours. In HCT116 tumors, it was 14.9 ± 0.9 before irradiation, 13.4 ± 0.9 at 30 minutes after 3 Gy irradiation, 9.1 ± 1.5 at 60 minutes, and 12.0 ± 1.5 at 24 hours. Median pO2 of HT29 tumors was 15.9 ± 1.0 before irradiation, After 3 Gy, 10 Gy, and 20 Gy irradiation, it was, respectively, 15.4 ± 1.1, 14.1 ± 0.3, and 12.7 ± 1.5 at 30 minutes, 14.0 ± 1.0, 13.6 ± 1.0, and 11.8 ± 1.3 at 60 minutes, 15.3 ± 0.6, 13.7 ± 0.5, and 11.4 ± 0.8 at 2 hours, 15.2 ± 0.7, 13.6 ± 1.0, and 13.7 ± 0.5 at 18 hours, 15.4 ± 0.6, 13.6 ± 0.8, and 13.9 ± 0.6 at 24 hours, and 15.2 ± 0.7, 13.8 ± 0.3, and 13.7 ± 0.5 at 30 hours. Immunohistochemical analysis suggested that the hypoxic fraction measured by the pO2 imaging correlated with the pimonidazole density in both HT29 and HCT116 tumors. ConclusionsThis study demonstrated the phenomenon of reoxygenation after irradiation in HT29 and HCT116 tumors by using EPR pO2 imaging. Degree of pO2 decrease and time to recover from pO2 decrease after irradiation depended on irradiation dose. This result indicated the possibility and importance of a new radiation therapy concept such as reoxygenation-based radiation therapy. This study demonstrated the phenomenon of reoxygenation after irradiation in HT29 and HCT116 tumors by using EPR pO2 imaging. Degree of pO2 decrease and time to recover from pO2 decrease after irradiation depended on irradiation dose. This result indicated the possibility and importance of a new radiation therapy concept such as reoxygenation-based radiation therapy." @default.
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• W2093701669 title "Pulsed Electron Paramagnetic Resonance Imaging for Evaluation of Reoxygenation in Murine Tumors: A New Reoxygenation Imaging for Radiation Therapy" @default.
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