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- W2093701908 abstract "In vitro studies of blood supersaturated with oxygen produced by hydrogen peroxide, show that rapid dissociation of the hydrogen peroxide occurs with subsequent bubble formation at an oxygen concentration dependent on the nature of the mixing process of hydrogen peroxide and blood. Oxygen bubble formation in the inferior mesenteric artery of rats caused by hydrogen peroxide infusion was observed to cause blockage of arteriolar and capillary blood flow. The bubbles in the arterioles became absorbed in 30 minutes but flow did not return in the capillaries under observation, although flow did continue in the precapillary shunts. A quantitative study on the amounts of hydrogen peroxide which can be added to circulating blood before oxygen bubble formation and capillary blockage occurs, was performed in the hind limbs of dogs. Sodium 22 clearance tests were used as an index of capillary function. A blood hydrogen peroxide concentration of 0·01–0·02 vol. per cent caused cessation of capillary flow which was consistent with a previous in vitro study which predicted the formation of bubbles above a blood concentration of 0·007 vol. per cent of H2O2." @default.
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- W2093701908 date "1968-10-01" @default.
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- W2093701908 title "Hydrogen peroxide and radiotherapy. Bubble formation in blood" @default.
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- W2093701908 doi "https://doi.org/10.1259/0007-1285-41-490-749" @default.
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