FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2093707906> ?p ?o ?g. }

• W2093707906 endingPage "9" @default.
• W2093707906 startingPage "1" @default.
• W2093707906 abstract "C8/119S is a mutant of recombinant Der f 2 (rDer f 2), and lacks a disulphide bond possessed by wild-type rDer f 2. In humans and mice, C8/119S has a very weak IgE-binding capacity compared with the wild-type, but possesses a T cell reactivity comparable to that of the wild-type. C8/119S may thus be a safe immunotherapeutic agent for house dust mite allergy. The aim of the present study was to evaluate whether the intranasal administration of C8/119S could suppress an immediate allergic reaction in mice sensitized with wild-type rDer f 2, possessing an allergic activity comparable to native counterparts purified from mite extract. Seven-week-old male A/J mice were immunized with wild-type rDer f 2 four times, and then intranasally administered 0.2-2 microg of wild-type, 0.2-20 microg of C8/119S, or PBS alone, three times a week for 4 weeks. Seven days after the last administration, the mice were examined for an immediate allergic reaction. The animals administered 2 microg of C8/119S (C2.0 group) showed significantly reduced immediate bronchoconstriction provoked by the i.v. injection of 1 and 10 microg of wild-type rDer f 2, compared with the PBS-treated mice. Similar results were obtained when we examined mice 10 weeks after the last administration. The reactions in the other groups given wild-type or C8/119S also tended to decrease in severity in comparison with the animals of the PBS group. The allergic phenotypes of the T cells, B cells, and basophils in the C2.0 group were shifted to that of naive mice without immunization. We conclude that C8/119S has hyposensitizing activities in mice sensitized with wild-type rDer f 2. C8/119S may be useful for immunotherapy of house dust mite allergy." @default.
• W2093707906 created "2016-06-24" @default.
• W2093707906 creator A5024037142 @default.
• W2093707906 creator A5036869700 @default.
• W2093707906 creator A5044427365 @default.
• W2093707906 creator A5065515771 @default.
• W2093707906 creator A5075876349 @default.
• W2093707906 creator A5080139718 @default.
• W2093707906 creator A5091749859 @default.
• W2093707906 date "1998-07-01" @default.
• W2093707906 modified "2023-09-30" @default.
• W2093707906 title "Hyposensitization to allergic reaction in rDer f 2-sensitized mice by the intranasal administration of a mutant of rDer f 2, C8/119S" @default.
• W2093707906 cites W1497127646 @default.
• W2093707906 cites W1509108153 @default.
• W2093707906 cites W1528328673 @default.
• W2093707906 cites W1540338306 @default.
• W2093707906 cites W1560419085 @default.
• W2093707906 cites W1655614253 @default.
• W2093707906 cites W1921048215 @default.
• W2093707906 cites W1963169432 @default.
• W2093707906 cites W1966866092 @default.
• W2093707906 cites W1968085770 @default.
• W2093707906 cites W1970594645 @default.
• W2093707906 cites W1972139541 @default.
• W2093707906 cites W1974694046 @default.
• W2093707906 cites W1978561383 @default.
• W2093707906 cites W1980045599 @default.
• W2093707906 cites W1984062235 @default.
• W2093707906 cites W1987386803 @default.
• W2093707906 cites W1987925923 @default.
• W2093707906 cites W1992480781 @default.
• W2093707906 cites W1994378521 @default.
• W2093707906 cites W1995100536 @default.
• W2093707906 cites W1999096644 @default.
• W2093707906 cites W1999241886 @default.
• W2093707906 cites W2005989655 @default.
• W2093707906 cites W2006118096 @default.
• W2093707906 cites W2006421422 @default.
• W2093707906 cites W2008157858 @default.
• W2093707906 cites W2008669313 @default.
• W2093707906 cites W2008878609 @default.
• W2093707906 cites W2009048532 @default.
• W2093707906 cites W2012769309 @default.
• W2093707906 cites W2012785799 @default.
• W2093707906 cites W2020086671 @default.
• W2093707906 cites W2021451119 @default.
• W2093707906 cites W2021475285 @default.
• W2093707906 cites W2026338022 @default.
• W2093707906 cites W2027752086 @default.
• W2093707906 cites W2028932256 @default.
• W2093707906 cites W2029693770 @default.
• W2093707906 cites W2034735991 @default.
• W2093707906 cites W2035821609 @default.
• W2093707906 cites W2039109411 @default.
• W2093707906 cites W2040845035 @default.
• W2093707906 cites W2044309378 @default.
• W2093707906 cites W2046698682 @default.
• W2093707906 cites W2047078985 @default.
• W2093707906 cites W2047181067 @default.
• W2093707906 cites W2047616366 @default.
• W2093707906 cites W2055773200 @default.
• W2093707906 cites W2061626952 @default.
• W2093707906 cites W2062298534 @default.
• W2093707906 cites W2066555469 @default.
• W2093707906 cites W2067573653 @default.
• W2093707906 cites W2074525021 @default.
• W2093707906 cites W2078817917 @default.
• W2093707906 cites W2079218165 @default.
• W2093707906 cites W2079816430 @default.
• W2093707906 cites W2081184287 @default.
• W2093707906 cites W2081676212 @default.
• W2093707906 cites W2085944673 @default.
• W2093707906 cites W2088680288 @default.
• W2093707906 cites W2094309254 @default.
• W2093707906 cites W2104715787 @default.
• W2093707906 cites W2110673488 @default.
• W2093707906 cites W2129886691 @default.
• W2093707906 cites W2133176033 @default.
• W2093707906 cites W2144653639 @default.
• W2093707906 cites W2162423641 @default.
• W2093707906 cites W2163739425 @default.
• W2093707906 cites W2166948911 @default.
• W2093707906 cites W2172466148 @default.
• W2093707906 cites W2325720596 @default.
• W2093707906 cites W2398470976 @default.
• W2093707906 cites W2406881293 @default.
• W2093707906 cites W2415518221 @default.
• W2093707906 cites W2417650947 @default.
• W2093707906 cites W2418595341 @default.
• W2093707906 cites W2441742454 @default.
• W2093707906 cites W2460213033 @default.
• W2093707906 cites W2616736093 @default.
• W2093707906 cites W4251371521 @default.
• W2093707906 doi "https://doi.org/10.1046/j.1365-2249.1998.00616.x" @default.
• W2093707906 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1905018" @default.
• W2093707906 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9697976" @default.
• W2093707906 hasPublicationYear "1998" @default.
• W2093707906 type Work @default.

• next