FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2093708759> ?p ?o ?g. }

• W2093708759 endingPage "1014" @default.
• W2093708759 startingPage "1008" @default.
• W2093708759 abstract "Glucocorticoids are widely used for the treatment of malignancy-associated hypercalcemia to delay the occurrence of an escape phenomenon inherent in calcitonin therapy. Using parathyroid hormone-related protein (PTHrP)-producing squamous carcinoma cells (T3M-1 and EC-GI) established in our laboratory, we investigated the in vitro effects of glucocorticoids and calcitonin on PTHrP mRNA expression in the cells and release of PTHrP into the culture medium. The PTHrP gene was constitutively expressed in the logarithmic growth phase in both squamous carcinoma cell lines. When these cells became superconfluent, PTHrP mRNA expression was greatly diminished in T3M-1 cells but was not distinctly diminished in EC-GI cells. Hydrocortisone inhibited the PTHrP mRNA expression in T3M-1 cells and EC-GI cells in a dose-dependent manner. In accordance with the decreased expression of PTHrP mRNA, the release of immunoreactive as well as bioactive PTHrP also decreased in the conditioned medium of glucocorticoid-treated cells. The minimal effective concentration of prednisolone was about 10(-7) M, which is readily attainable in the serum of patients treated with the agent. Calcitonin and indomethacin did not affect the PTHrP mRNA expression or PTHrP release into the medium. Calcitonin did not modulate the hydrocortisone-induced inhibition of PTHrP production. These in vitro findings suggest that the combined use of glucocorticoids and calcitonin plays a beneficial role in the treatment of malignancy-associated hypercalcemia, since the steroid hormone can suppress PTHrP mRNA expression and release of bioactive PTHrP in certain PTHrP-producing tumors." @default.
• W2093708759 created "2016-06-24" @default.
• W2093708759 creator A5030293363 @default.
• W2093708759 creator A5033893823 @default.
• W2093708759 creator A5040481424 @default.
• W2093708759 creator A5048746190 @default.
• W2093708759 creator A5074972223 @default.
• W2093708759 creator A5075205053 @default.
• W2093708759 creator A5084837866 @default.
• W2093708759 date "1991-09-01" @default.
• W2093708759 modified "2023-09-27" @default.
• W2093708759 title "Effects of Glucocorticoids and Calcitonin on Parathyroid Hormone-related Protein (PTHrP) Gene Expression and PTHrP Release in Human Cancer Cells Causing Humoral Hypercalcemia¹" @default.
• W2093708759 cites W1542233468 @default.
• W2093708759 cites W1706076031 @default.
• W2093708759 cites W1982346955 @default.
• W2093708759 cites W1999668025 @default.
• W2093708759 cites W2017211434 @default.
• W2093708759 cites W2026937576 @default.
• W2093708759 cites W2029844524 @default.
• W2093708759 cites W2031139386 @default.
• W2093708759 cites W2060333964 @default.
• W2093708759 cites W2063497701 @default.
• W2093708759 cites W2066160869 @default.
• W2093708759 cites W2073374044 @default.
• W2093708759 cites W2078236994 @default.
• W2093708759 cites W2085355931 @default.
• W2093708759 cites W2086037419 @default.
• W2093708759 cites W2092399669 @default.
• W2093708759 cites W2095426443 @default.
• W2093708759 cites W2095606575 @default.
• W2093708759 cites W2098491997 @default.
• W2093708759 cites W2100443515 @default.
• W2093708759 cites W2103896404 @default.
• W2093708759 cites W2111218461 @default.
• W2093708759 cites W2210892901 @default.
• W2093708759 cites W2576734941 @default.
• W2093708759 cites W4290344173 @default.
• W2093708759 doi "https://doi.org/10.1111/j.1349-7006.1991.tb01936.x" @default.
• W2093708759 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5918602" @default.
• W2093708759 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1938595" @default.
• W2093708759 hasPublicationYear "1991" @default.
• W2093708759 type Work @default.
• W2093708759 sameAs 2093708759 @default.
• W2093708759 citedByCount "22" @default.
• W2093708759 countsByYear W20937087592012 @default.
• W2093708759 countsByYear W20937087592013 @default.
• W2093708759 countsByYear W20937087592015 @default.
• W2093708759 countsByYear W20937087592018 @default.
• W2093708759 countsByYear W20937087592023 @default.
• W2093708759 crossrefType "journal-article" @default.
• W2093708759 hasAuthorship W2093708759A5030293363 @default.
• W2093708759 hasAuthorship W2093708759A5033893823 @default.
• W2093708759 hasAuthorship W2093708759A5040481424 @default.
• W2093708759 hasAuthorship W2093708759A5048746190 @default.
• W2093708759 hasAuthorship W2093708759A5074972223 @default.
• W2093708759 hasAuthorship W2093708759A5075205053 @default.
• W2093708759 hasAuthorship W2093708759A5084837866 @default.
• W2093708759 hasBestOaLocation W20937087591 @default.
• W2093708759 hasConcept C104317684 @default.
• W2093708759 hasConcept C105580179 @default.
• W2093708759 hasConcept C121608353 @default.
• W2093708759 hasConcept C126322002 @default.
• W2093708759 hasConcept C134018914 @default.
• W2093708759 hasConcept C150194340 @default.
• W2093708759 hasConcept C185592680 @default.
• W2093708759 hasConcept C202751555 @default.
• W2093708759 hasConcept C2778828131 @default.
• W2093708759 hasConcept C2779627488 @default.
• W2093708759 hasConcept C2780841215 @default.
• W2093708759 hasConcept C2781208988 @default.
• W2093708759 hasConcept C2781399356 @default.
• W2093708759 hasConcept C519063684 @default.
• W2093708759 hasConcept C54355233 @default.
• W2093708759 hasConcept C55493867 @default.
• W2093708759 hasConcept C71924100 @default.
• W2093708759 hasConcept C81885089 @default.
• W2093708759 hasConcept C86803240 @default.
• W2093708759 hasConcept C96232424 @default.
• W2093708759 hasConceptScore W2093708759C104317684 @default.
• W2093708759 hasConceptScore W2093708759C105580179 @default.
• W2093708759 hasConceptScore W2093708759C121608353 @default.
• W2093708759 hasConceptScore W2093708759C126322002 @default.
• W2093708759 hasConceptScore W2093708759C134018914 @default.
• W2093708759 hasConceptScore W2093708759C150194340 @default.
• W2093708759 hasConceptScore W2093708759C185592680 @default.
• W2093708759 hasConceptScore W2093708759C202751555 @default.
• W2093708759 hasConceptScore W2093708759C2778828131 @default.
• W2093708759 hasConceptScore W2093708759C2779627488 @default.
• W2093708759 hasConceptScore W2093708759C2780841215 @default.
• W2093708759 hasConceptScore W2093708759C2781208988 @default.
• W2093708759 hasConceptScore W2093708759C2781399356 @default.
• W2093708759 hasConceptScore W2093708759C519063684 @default.
• W2093708759 hasConceptScore W2093708759C54355233 @default.
• W2093708759 hasConceptScore W2093708759C55493867 @default.
• W2093708759 hasConceptScore W2093708759C71924100 @default.
• W2093708759 hasConceptScore W2093708759C81885089 @default.
• W2093708759 hasConceptScore W2093708759C86803240 @default.
• W2093708759 hasConceptScore W2093708759C96232424 @default.

• next