FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2093717567> ?p ?o ?g. }

• W2093717567 endingPage "328" @default.
• W2093717567 startingPage "320" @default.
• W2093717567 abstract "The rat pineal gland with its circadian noradrenaline-regulated melatonin rhythm is an excellent model for studying adrenergic signal transduction with respect to cAMP and cGMP formation. The stimulatory G(s) proteins play a well-established role in this process. In contrast, the potential roles of the inhibitory G(i) proteins, the functionally unclear other G(o) proteins, and a number of G protein subtypes are not known. The present study examines the effects on beta(1)- and beta(1)-plus-alpha(1)-stimulated cAMP and cGMP formation of a number of G protein modulators in rat pinealocyte suspension cultures. The effects of the nitric oxide donor sodium nitroprusside on cGMP were also examined. The results showed that drugs that activate G proteins of the G(i)/G(o) family, i.e., pertussis toxin, mastoparan, and compound 48/80, had no effect on unstimulated, isoproterenol (beta(1))-stimulated, or combined isoproterenol/phenylephrine (beta(1)-plus()-alpha(1))-stimulated cAMP and cGMP accumulation. However, in this experimental paradigm, the inhibitors of sulfhydryl G proteins (N-ethylmaleimide) and those of phospholipase A2-related G proteins (isotetrandrine) exerted a clear inhibitory effect. Sodium-nitroprusside-stimulated cGMP accumulation was also inhibited. These results confirm a previous report that members of the G(i)/G(o) family, which are present in the rat pineal gland, do not play a major role in adrenergic signal transduction. The new finding that sulfhydryl G proteins and phospholipase A2-associated G proteins exert a clear stimulatory effect on adrenergic signal transduction suggests that they are subtypes of G(s) proteins." @default.
• W2093717567 created "2016-06-24" @default.
• W2093717567 creator A5009027535 @default.
• W2093717567 creator A5020603065 @default.
• W2093717567 creator A5053247158 @default.
• W2093717567 creator A5077998018 @default.
• W2093717567 date "2001-06-01" @default.
• W2093717567 modified "2023-10-18" @default.
• W2093717567 title "Sulfhydryl G Proteins and Phospholipase A2-Associated G Proteins Are Involved in Adrenergic Signal Transduction in the Rat Pineal Gland" @default.
• W2093717567 cites W1493349125 @default.
• W2093717567 cites W1517879640 @default.
• W2093717567 cites W1523578031 @default.
• W2093717567 cites W1529148196 @default.
• W2093717567 cites W1552421156 @default.
• W2093717567 cites W1555929637 @default.
• W2093717567 cites W1587748294 @default.
• W2093717567 cites W1591392705 @default.
• W2093717567 cites W1668450698 @default.
• W2093717567 cites W1775749144 @default.
• W2093717567 cites W1833489208 @default.
• W2093717567 cites W1964409150 @default.
• W2093717567 cites W1968498137 @default.
• W2093717567 cites W1970835980 @default.
• W2093717567 cites W1974077178 @default.
• W2093717567 cites W1984386521 @default.
• W2093717567 cites W1985491580 @default.
• W2093717567 cites W1997600051 @default.
• W2093717567 cites W1999056362 @default.
• W2093717567 cites W2004790444 @default.
• W2093717567 cites W2021618240 @default.
• W2093717567 cites W2027892263 @default.
• W2093717567 cites W2028188872 @default.
• W2093717567 cites W2028791783 @default.
• W2093717567 cites W2032002772 @default.
• W2093717567 cites W2035193900 @default.
• W2093717567 cites W2043431751 @default.
• W2093717567 cites W2048766645 @default.
• W2093717567 cites W2055407799 @default.
• W2093717567 cites W2055846085 @default.
• W2093717567 cites W2056210477 @default.
• W2093717567 cites W2061402105 @default.
• W2093717567 cites W2063929437 @default.
• W2093717567 cites W2066857634 @default.
• W2093717567 cites W2067382519 @default.
• W2093717567 cites W2073569988 @default.
• W2093717567 cites W2076036347 @default.
• W2093717567 cites W2077061468 @default.
• W2093717567 cites W2078244978 @default.
• W2093717567 cites W2082301978 @default.
• W2093717567 cites W2082958216 @default.
• W2093717567 cites W2091031608 @default.
• W2093717567 cites W2093603461 @default.
• W2093717567 cites W2122903921 @default.
• W2093717567 cites W2133067333 @default.
• W2093717567 cites W2141346516 @default.
• W2093717567 cites W2154860936 @default.
• W2093717567 cites W2164522979 @default.
• W2093717567 cites W2168503470 @default.
• W2093717567 cites W2191741488 @default.
• W2093717567 cites W27088691 @default.
• W2093717567 cites W4213311311 @default.
• W2093717567 cites W4245694795 @default.
• W2093717567 cites W4302413503 @default.
• W2093717567 doi "https://doi.org/10.1006/gcen.2001.7645" @default.
• W2093717567 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11356044" @default.
• W2093717567 hasPublicationYear "2001" @default.
• W2093717567 type Work @default.
• W2093717567 sameAs 2093717567 @default.
• W2093717567 citedByCount "1" @default.
• W2093717567 crossrefType "journal-article" @default.
• W2093717567 hasAuthorship W2093717567A5009027535 @default.
• W2093717567 hasAuthorship W2093717567A5020603065 @default.
• W2093717567 hasAuthorship W2093717567A5053247158 @default.
• W2093717567 hasAuthorship W2093717567A5077998018 @default.
• W2093717567 hasConcept C126322002 @default.
• W2093717567 hasConcept C134018914 @default.
• W2093717567 hasConcept C202023056 @default.
• W2093717567 hasConcept C2778182776 @default.
• W2093717567 hasConcept C2778597717 @default.
• W2093717567 hasConcept C2779610285 @default.
• W2093717567 hasConcept C2780059843 @default.
• W2093717567 hasConcept C49773422 @default.
• W2093717567 hasConcept C519581460 @default.
• W2093717567 hasConcept C62478195 @default.
• W2093717567 hasConcept C71924100 @default.
• W2093717567 hasConcept C80631254 @default.
• W2093717567 hasConcept C86803240 @default.
• W2093717567 hasConcept C95444343 @default.
• W2093717567 hasConceptScore W2093717567C126322002 @default.
• W2093717567 hasConceptScore W2093717567C134018914 @default.
• W2093717567 hasConceptScore W2093717567C202023056 @default.
• W2093717567 hasConceptScore W2093717567C2778182776 @default.
• W2093717567 hasConceptScore W2093717567C2778597717 @default.
• W2093717567 hasConceptScore W2093717567C2779610285 @default.
• W2093717567 hasConceptScore W2093717567C2780059843 @default.
• W2093717567 hasConceptScore W2093717567C49773422 @default.
• W2093717567 hasConceptScore W2093717567C519581460 @default.
• W2093717567 hasConceptScore W2093717567C62478195 @default.

• next