Matches in SemOpenAlex for { <https://semopenalex.org/work/W2093718109> ?p ?o ?g. }
Showing items 1 to 72 of
72
with 100 items per page.
- W2093718109 endingPage "6" @default.
- W2093718109 startingPage "6" @default.
- W2093718109 abstract "Hepatocyte growth factor (HGF) has recently attracted a considerable amount of attention as a stromal-derived mediator in tumor-stromal interactions, particularly because of its close involvement in cancer invasion and metastasis, and (−)-epigallocatechin-3-gallate (EGCG) can modulate the cell signaling associated with angiogenesis, metastasis, and migration of cancer cells. In the present study, we have investigated the effects of HGF on invasion and metastasis of hypopharyngeal carcinoma cells and the effect of EGCG on blocking HGF-induced invasion and metastasis in these cells. We found that HGF promoted the autophosphorylation of c-Met, HGF receptor, and that HGF-induced proliferation, colony dispersion, migration and invasion of tumors. We also observed that HGF enhanced the activity of matrix metalloproteinase (MMP)-9 and urokinase-type plasminogen activator (uPA) in hypopharyngeal carcinoma cells. In addition, HGF-induced the activation of Akt and Erk pathway as a downstreaming pathway of invasion. On the other hand, EGCG at physiologically relevant concentration (1 μM) suppressed HGF-induced tumor motility and MMP-9 and uPA activities, and the suppression of Akt and Erk pathway by EGCG was one of the downstream mechanisms to facilitate EGCG-induced anti-invasion effects. These results suggest that EGCG may serve as a therapeutic agent to inhibit HGF-induced invasion in hypopharyngeal carcinoma patients." @default.
- W2093718109 created "2016-06-24" @default.
- W2093718109 creator A5026064194 @default.
- W2093718109 date "2008-07-01" @default.
- W2093718109 modified "2023-09-25" @default.
- W2093718109 title "Paradigm shift in proteomics – Implication for biomarker discovery and evaluation" @default.
- W2093718109 doi "https://doi.org/10.1016/s1359-6349(08)71198-4" @default.
- W2093718109 hasPublicationYear "2008" @default.
- W2093718109 type Work @default.
- W2093718109 sameAs 2093718109 @default.
- W2093718109 citedByCount "0" @default.
- W2093718109 crossrefType "journal-article" @default.
- W2093718109 hasAuthorship W2093718109A5026064194 @default.
- W2093718109 hasConcept C121608353 @default.
- W2093718109 hasConcept C126322002 @default.
- W2093718109 hasConcept C137738243 @default.
- W2093718109 hasConcept C1491633281 @default.
- W2093718109 hasConcept C16930146 @default.
- W2093718109 hasConcept C170493617 @default.
- W2093718109 hasConcept C185592680 @default.
- W2093718109 hasConcept C200786668 @default.
- W2093718109 hasConcept C2776996007 @default.
- W2093718109 hasConcept C2779013556 @default.
- W2093718109 hasConcept C2780394083 @default.
- W2093718109 hasConcept C502942594 @default.
- W2093718109 hasConcept C55493867 @default.
- W2093718109 hasConcept C57074206 @default.
- W2093718109 hasConcept C62478195 @default.
- W2093718109 hasConcept C71924100 @default.
- W2093718109 hasConcept C75217442 @default.
- W2093718109 hasConcept C86803240 @default.
- W2093718109 hasConcept C95444343 @default.
- W2093718109 hasConceptScore W2093718109C121608353 @default.
- W2093718109 hasConceptScore W2093718109C126322002 @default.
- W2093718109 hasConceptScore W2093718109C137738243 @default.
- W2093718109 hasConceptScore W2093718109C1491633281 @default.
- W2093718109 hasConceptScore W2093718109C16930146 @default.
- W2093718109 hasConceptScore W2093718109C170493617 @default.
- W2093718109 hasConceptScore W2093718109C185592680 @default.
- W2093718109 hasConceptScore W2093718109C200786668 @default.
- W2093718109 hasConceptScore W2093718109C2776996007 @default.
- W2093718109 hasConceptScore W2093718109C2779013556 @default.
- W2093718109 hasConceptScore W2093718109C2780394083 @default.
- W2093718109 hasConceptScore W2093718109C502942594 @default.
- W2093718109 hasConceptScore W2093718109C55493867 @default.
- W2093718109 hasConceptScore W2093718109C57074206 @default.
- W2093718109 hasConceptScore W2093718109C62478195 @default.
- W2093718109 hasConceptScore W2093718109C71924100 @default.
- W2093718109 hasConceptScore W2093718109C75217442 @default.
- W2093718109 hasConceptScore W2093718109C86803240 @default.
- W2093718109 hasConceptScore W2093718109C95444343 @default.
- W2093718109 hasIssue "9" @default.
- W2093718109 hasLocation W20937181091 @default.
- W2093718109 hasOpenAccess W2093718109 @default.
- W2093718109 hasPrimaryLocation W20937181091 @default.
- W2093718109 hasRelatedWork W1983017595 @default.
- W2093718109 hasRelatedWork W2060716574 @default.
- W2093718109 hasRelatedWork W2081370006 @default.
- W2093718109 hasRelatedWork W2088276717 @default.
- W2093718109 hasRelatedWork W2291930530 @default.
- W2093718109 hasRelatedWork W2917496558 @default.
- W2093718109 hasRelatedWork W3003597902 @default.
- W2093718109 hasRelatedWork W3009445293 @default.
- W2093718109 hasRelatedWork W3114532332 @default.
- W2093718109 hasRelatedWork W4283771460 @default.
- W2093718109 hasVolume "6" @default.
- W2093718109 isParatext "false" @default.
- W2093718109 isRetracted "false" @default.
- W2093718109 magId "2093718109" @default.
- W2093718109 workType "article" @default.