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• W2093722467 abstract "Recent studies suggested that pharmacological manipulation of angiotensin ligands may be of clinical importance in slowing the cognitive deterioration seen Alzheimer's disease. Although angiotensin II is the major effector of the renin-angiotensin system (RAS), various other angiotensins are now recognized as being biologically active. Angiotensin (1-7) is considered to be an important peptide fragment of the RAS, because it has important actions which are often opposite to those of angiotensin II. Losartan, PD123177 (AT1 and AT2 antagonist), captopril (ACE inhibitor), angiotensin II andangiotensin 1-7 were administered in the left cerebral ventricle. The ability of the rats to acquire the operant task was studied by Y-maze task, passive avoidance and radial-arm-maze task. The anxiety state was measured in elevated-plus-maze. We also assessed the levels of some enzymatic antioxidant defences like superoxid dismutase (SOD) and glutathione peroxidase (GPX), as well as lipid oxidation makers like MDA (malondialdehyde), from the temporal lobe. In Y maze, radial arm-maze and passive avoidance task the inhibition of Ang II and the administration of angiotensin 1-7 resulted in an increase of both short-term and long-term memory. In elevated plus maze measuring anxiety, losartan, PD 123177, captopril and angiotensin 1-7 diminished anxiety state, while angiotensin II exerted anxiety-like effects. Alterations in the specific activity of the antioxidant enzymes were found in the temporal lobe of angiotensin II-treated rats. Also, the level of MDA was increased in angiotensinII treated rats. On the contrary, blocking of angiotensin II or administration of angiotensin 1-7 exerted antioxidant effects. The use of antihypertensive drugs, particularly ACE inhibitors and angiotensin receptor blockers, may be associated with a lower rate of cognitive decline in older adults and possibly in those with Alzheimer disease. Also, manipulation of the central angiotensins might be considered as a therapeutic target in the treatment of cognitive dysfunctions. A better understanding of the interactions between the various angiotensins, memory processes and neuronal oxidative stress is necessary and may lead to new the rapeutic treatments." @default.
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• W2093722467 date "2011-07-01" @default.
• W2093722467 modified "2023-10-18" @default.
• W2093722467 title "P1-001: The effects of angiotensin II and angiotensin 1-7 in cognitive processes and oxidative stress in rats. Relevance for Alzheimer's disease" @default.
• W2093722467 doi "https://doi.org/10.1016/j.jalz.2011.05.281" @default.
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