FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2093726957> ?p ?o ?g. }

• W2093726957 abstract "Like factories in miniature, cells must organize complex arrays of machinery into robust and accurate processes. It comes as no surprise, then, that diverse quality control and precision mechanisms underlie virtually all aspects of cellular function. In this issue, we are pleased to present a group of Review articles exploring facets of key cellular infrastructure and the consequences of their failure. These Reviews focus on four particular areas of rapidly advancing research relating to cytoskeleton-based structures, organellar membranes, protein biosynthesis, and chromosome integrity.Our Review Feature begins with a discussion of cytoskeleton-based structures, focusing on those built from microtubules, from Radhika Subramanian and Tarun Kapoor. Beyond their obvious structural roles, dynamic assemblies of microtubules are also central to diverse cellular processes such as chromosome segregation, organelle positioning, and cilium formation. How do regulatory inputs ensure the essential qualities, like shape and size, of these architectures? Subramanian and Kapoor argue that basic recurring structural motifs in cytoskeletal arrays provide points of regulation and promote self-organized assembly of diverse architectures.Copyright iStockphoto/RomanOkopnyView Large Image | View Hi-Res Image | Download PowerPoint SlideAkin to the precision necessary to build specific cellular structures, the membrane surfaces of organelles such as the ER and Golgi must also provide precisely defined domains to facilitate a multitude of specific protein interactions important to signal transduction, vesicular trafficking, and lipid metabolism. Joelle Bigay and Bruno Antonny provide a conceptual framework for understanding how changes in the deceptively simple physical parameters of membrane curvature, lipid packing, and electrostatics provide the necessary inputs that generate specificity in protein-membrane interactions.Of course, precision mechanisms are far from being fail-safe in the maintenance of fidelity. Thus, there exist additional layers of quality control dedicated to recognizing when these mechanisms have failed and providing damage control. No different from an assembly line in a factory, the assessment and removal of defective products at multiple stages throughout the manufacturing process provides added degrees of fidelity. Monica Rodrigo-Brenni and Ramanujan Hegde explore this idea of additive quality-control systems and the coupling of synthesis and degradation in the context of protein biosynthesis. Not only do sequential checkpoints survey the nascent polypeptide throughout its maturation, but the protein biosynthetic machinery is also increasingly found to associate with protein degradation factors.Unlike protein biosynthesis, in which degradation of defective products is the dominant mode of quality control, safeguarding the integrity of the genome must rely instead on repair. Not surprisingly, failure of these error-correction mechanisms has catastrophic consequences not only for chromosome integrity but also for cellular and organismal health. Focusing on the recently discovered phenomenon of chromothripsis, the complex and extensive gross chromosomal rearrangements observed in certain cancer cells, Mathew Jones and Prasad Jallepalli review the processes that regulate chromosome integrity and delve into the ramifications of their dysfunction.We hope you will enjoy reading these Reviews and considering the diverse range of cellular strategies for quality control and fidelity that they present.On behalf of the Developmental Cell editorial team." @default.
• W2093726957 created "2016-06-24" @default.
• W2093726957 creator A5021278321 @default.
• W2093726957 date "2012-11-01" @default.
• W2093726957 modified "2023-09-30" @default.
• W2093726957 title "Quality Control and Fidelity" @default.
• W2093726957 doi "https://doi.org/10.1016/j.devcel.2012.10.026" @default.
• W2093726957 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23153483" @default.
• W2093726957 hasPublicationYear "2012" @default.
• W2093726957 type Work @default.
• W2093726957 sameAs 2093726957 @default.
• W2093726957 citedByCount "0" @default.
• W2093726957 crossrefType "journal-article" @default.
• W2093726957 hasAuthorship W2093726957A5021278321 @default.
• W2093726957 hasBestOaLocation W20937269571 @default.
• W2093726957 hasConcept C119062480 @default.
• W2093726957 hasConcept C14036430 @default.
• W2093726957 hasConcept C142669718 @default.
• W2093726957 hasConcept C1491633281 @default.
• W2093726957 hasConcept C158617107 @default.
• W2093726957 hasConcept C168240541 @default.
• W2093726957 hasConcept C20418707 @default.
• W2093726957 hasConcept C2777278457 @default.
• W2093726957 hasConcept C39944091 @default.
• W2093726957 hasConcept C41625074 @default.
• W2093726957 hasConcept C54355233 @default.
• W2093726957 hasConcept C70721500 @default.
• W2093726957 hasConcept C86803240 @default.
• W2093726957 hasConcept C95444343 @default.
• W2093726957 hasConceptScore W2093726957C119062480 @default.
• W2093726957 hasConceptScore W2093726957C14036430 @default.
• W2093726957 hasConceptScore W2093726957C142669718 @default.
• W2093726957 hasConceptScore W2093726957C1491633281 @default.
• W2093726957 hasConceptScore W2093726957C158617107 @default.
• W2093726957 hasConceptScore W2093726957C168240541 @default.
• W2093726957 hasConceptScore W2093726957C20418707 @default.
• W2093726957 hasConceptScore W2093726957C2777278457 @default.
• W2093726957 hasConceptScore W2093726957C39944091 @default.
• W2093726957 hasConceptScore W2093726957C41625074 @default.
• W2093726957 hasConceptScore W2093726957C54355233 @default.
• W2093726957 hasConceptScore W2093726957C70721500 @default.
• W2093726957 hasConceptScore W2093726957C86803240 @default.
• W2093726957 hasConceptScore W2093726957C95444343 @default.
• W2093726957 hasLocation W20937269571 @default.
• W2093726957 hasLocation W20937269572 @default.
• W2093726957 hasOpenAccess W2093726957 @default.
• W2093726957 hasPrimaryLocation W20937269571 @default.
• W2093726957 hasRelatedWork W156003978 @default.
• W2093726957 hasRelatedWork W1629621594 @default.
• W2093726957 hasRelatedWork W1973582015 @default.
• W2093726957 hasRelatedWork W2057968730 @default.
• W2093726957 hasRelatedWork W2071081233 @default.
• W2093726957 hasRelatedWork W2081069775 @default.
• W2093726957 hasRelatedWork W2086908552 @default.
• W2093726957 hasRelatedWork W2314581359 @default.
• W2093726957 hasRelatedWork W2332468347 @default.
• W2093726957 hasRelatedWork W2337073629 @default.
• W2093726957 hasRelatedWork W2409808796 @default.
• W2093726957 hasRelatedWork W2473711714 @default.
• W2093726957 hasRelatedWork W2565518405 @default.
• W2093726957 hasRelatedWork W2582467215 @default.
• W2093726957 hasRelatedWork W2732134855 @default.
• W2093726957 hasRelatedWork W2987812001 @default.
• W2093726957 hasRelatedWork W3029678772 @default.
• W2093726957 hasRelatedWork W3152079138 @default.
• W2093726957 hasRelatedWork W79016611 @default.
• W2093726957 hasRelatedWork W2034101325 @default.
• W2093726957 isParatext "false" @default.
• W2093726957 isRetracted "false" @default.
• W2093726957 magId "2093726957" @default.
• W2093726957 workType "article" @default.