FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2093728671> ?p ?o ?g. }

• W2093728671 endingPage "898" @default.
• W2093728671 startingPage "891" @default.
• W2093728671 abstract "Previous research has suggested the therapeutic potential of glutamate-modulating agents for severe mood and anxiety disorders, potentially resulting from enhancement of neuroplasticity. We used proton magnetic resonance spectroscopic imaging ((1)H MRSI) to examine the acute and chronic effects of the glutamate-release inhibitor riluzole on hippocampal N-acetylaspartate (NAA), a neuronal marker, in patients with generalized anxiety disorder (GAD) and examined the relationship between changes in NAA and clinical outcome.Fourteen medication-free GAD patients were administered open-label riluzole and then evaluated by (1)H MRSI before drug administration, and 24 hours and 8 weeks following treatment. Patients were identified as responders (n = 9) or nonresponders (n = 5). Seven untreated, medically healthy volunteers, comparable in age, sex, IQ, and body mass index to the patients, received scans at the same time intervals. Molar NAA concentrations in bilateral hippocampus, and change in anxiety ratings were the primary outcome measures.A group-by-time interaction was found, with riluzole responders showing mean increases in hippocampal NAA across the three time points, whereas nonresponders had decreases over time. In GAD patients at Week 8, hippocampal NAA concentration and proportional increase in NAA from baseline both were positively associated with improvements in worry and clinician-rated anxiety.These preliminary data support a specific association between hippocampal NAA and symptom alleviation following riluzole treatment in GAD. Placebo-controlled investigations that examine hippocampal NAA as a viable surrogate endpoint for clinical trials of neuroprotective and plasticity-enhancing agents are warranted." @default.
• W2093728671 created "2016-06-24" @default.
• W2093728671 creator A5003370819 @default.
• W2093728671 creator A5012699156 @default.
• W2093728671 creator A5023336112 @default.
• W2093728671 creator A5029763155 @default.
• W2093728671 creator A5055497986 @default.
• W2093728671 creator A5063655069 @default.
• W2093728671 creator A5091643041 @default.
• W2093728671 date "2008-05-01" @default.
• W2093728671 modified "2023-10-16" @default.
• W2093728671 title "Hippocampal N-Acetylaspartate Concentration and Response to Riluzole in Generalized Anxiety Disorder" @default.
• W2093728671 cites W1550462067 @default.
• W2093728671 cites W1583604396 @default.
• W2093728671 cites W1860444553 @default.
• W2093728671 cites W1966885996 @default.
• W2093728671 cites W1968886841 @default.
• W2093728671 cites W1968966534 @default.
• W2093728671 cites W1969969013 @default.
• W2093728671 cites W1970076964 @default.
• W2093728671 cites W1978265841 @default.
• W2093728671 cites W1983568884 @default.
• W2093728671 cites W1986900475 @default.
• W2093728671 cites W1987742261 @default.
• W2093728671 cites W1989434587 @default.
• W2093728671 cites W1992050922 @default.
• W2093728671 cites W1992094266 @default.
• W2093728671 cites W1994048221 @default.
• W2093728671 cites W1995671210 @default.
• W2093728671 cites W1999391547 @default.
• W2093728671 cites W1999825042 @default.
• W2093728671 cites W2001866454 @default.
• W2093728671 cites W2014884007 @default.
• W2093728671 cites W2022700331 @default.
• W2093728671 cites W2023081218 @default.
• W2093728671 cites W2026412461 @default.
• W2093728671 cites W2027290785 @default.
• W2093728671 cites W2035296124 @default.
• W2093728671 cites W2039961483 @default.
• W2093728671 cites W2043735698 @default.
• W2093728671 cites W2051263750 @default.
• W2093728671 cites W2054154633 @default.
• W2093728671 cites W2063779366 @default.
• W2093728671 cites W2067230536 @default.
• W2093728671 cites W2069544569 @default.
• W2093728671 cites W2073686836 @default.
• W2093728671 cites W2080135883 @default.
• W2093728671 cites W2082071999 @default.
• W2093728671 cites W2084298829 @default.
• W2093728671 cites W2098906620 @default.
• W2093728671 cites W2099018998 @default.
• W2093728671 cites W2102326989 @default.
• W2093728671 cites W2114613490 @default.
• W2093728671 cites W2127341709 @default.
• W2093728671 cites W2127926155 @default.
• W2093728671 cites W2133185912 @default.
• W2093728671 cites W2137992068 @default.
• W2093728671 cites W2155941672 @default.
• W2093728671 cites W2160070901 @default.
• W2093728671 cites W2160589013 @default.
• W2093728671 cites W2170684975 @default.
• W2093728671 cites W2171928025 @default.
• W2093728671 doi "https://doi.org/10.1016/j.biopsych.2007.09.012" @default.
• W2093728671 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2385784" @default.
• W2093728671 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18028881" @default.
• W2093728671 hasPublicationYear "2008" @default.
• W2093728671 type Work @default.
• W2093728671 sameAs 2093728671 @default.
• W2093728671 citedByCount "56" @default.
• W2093728671 countsByYear W20937286712012 @default.
• W2093728671 countsByYear W20937286712013 @default.
• W2093728671 countsByYear W20937286712014 @default.
• W2093728671 countsByYear W20937286712015 @default.
• W2093728671 countsByYear W20937286712016 @default.
• W2093728671 countsByYear W20937286712017 @default.
• W2093728671 countsByYear W20937286712018 @default.
• W2093728671 countsByYear W20937286712019 @default.
• W2093728671 countsByYear W20937286712020 @default.
• W2093728671 countsByYear W20937286712021 @default.
• W2093728671 countsByYear W20937286712022 @default.
• W2093728671 crossrefType "journal-article" @default.
• W2093728671 hasAuthorship W2093728671A5003370819 @default.
• W2093728671 hasAuthorship W2093728671A5012699156 @default.
• W2093728671 hasAuthorship W2093728671A5023336112 @default.
• W2093728671 hasAuthorship W2093728671A5029763155 @default.
• W2093728671 hasAuthorship W2093728671A5055497986 @default.
• W2093728671 hasAuthorship W2093728671A5063655069 @default.
• W2093728671 hasAuthorship W2093728671A5091643041 @default.
• W2093728671 hasBestOaLocation W20937286712 @default.
• W2093728671 hasConcept C118552586 @default.
• W2093728671 hasConcept C126322002 @default.
• W2093728671 hasConcept C142724271 @default.
• W2093728671 hasConcept C148762608 @default.
• W2093728671 hasConcept C15744967 @default.
• W2093728671 hasConcept C170493617 @default.
• W2093728671 hasConcept C204787440 @default.
• W2093728671 hasConcept C27081682 @default.
• W2093728671 hasConcept C2779319286 @default.

• next