Matches in SemOpenAlex for { <https://semopenalex.org/work/W2093732800> ?p ?o ?g. }
- W2093732800 endingPage "386" @default.
- W2093732800 startingPage "379" @default.
- W2093732800 abstract "Human embryonic stem cells (hESCs) regularly acquire nonrandom genomic aberrations during culture, raising concerns about their safe therapeutic application. The International Stem Cell Initiative identified a copy number variant (CNV) amplification of chromosome 20q11.21 in 25% of hESC lines displaying a normal karyotype. By comparing four cell lines paired for the presence or absence of this CNV, we show that those containing this amplicon have higher population doubling rates, attributable to enhanced cell survival through resistance to apoptosis. Of the three genes encoded within the minimal amplicon and expressed in hESCs, only overexpression of BCL2L1 (BCL-XL isoform) provides control cells with growth characteristics similar to those of CNV-containing cells, whereas inhibition of BCL-XL suppresses the growth advantage of CNV cells, establishing BCL2L1 as a driver mutation. Amplification of the 20q11.21 region is also detectable in human embryonal carcinoma cell lines and some teratocarcinomas, linking this mutation with malignant transformation." @default.
- W2093732800 created "2016-06-24" @default.
- W2093732800 creator A5001644376 @default.
- W2093732800 creator A5008270331 @default.
- W2093732800 creator A5026456188 @default.
- W2093732800 creator A5031360571 @default.
- W2093732800 creator A5039803307 @default.
- W2093732800 creator A5052730567 @default.
- W2093732800 creator A5062422399 @default.
- W2093732800 creator A5069996996 @default.
- W2093732800 creator A5083420672 @default.
- W2093732800 creator A5085891063 @default.
- W2093732800 creator A5089685702 @default.
- W2093732800 creator A5090913554 @default.
- W2093732800 date "2013-11-01" @default.
- W2093732800 modified "2023-09-30" @default.
- W2093732800 title "BCL-XL Mediates the Strong Selective Advantage of a 20q11.21 Amplification Commonly Found in Human Embryonic Stem Cell Cultures" @default.
- W2093732800 cites W1976501240 @default.
- W2093732800 cites W1978590853 @default.
- W2093732800 cites W1988865085 @default.
- W2093732800 cites W1992396964 @default.
- W2093732800 cites W1992949513 @default.
- W2093732800 cites W1995354282 @default.
- W2093732800 cites W1996659151 @default.
- W2093732800 cites W2002433385 @default.
- W2093732800 cites W2003935383 @default.
- W2093732800 cites W2022489847 @default.
- W2093732800 cites W2022534144 @default.
- W2093732800 cites W2028193303 @default.
- W2093732800 cites W2030299494 @default.
- W2093732800 cites W2040561782 @default.
- W2093732800 cites W2044877927 @default.
- W2093732800 cites W2046839020 @default.
- W2093732800 cites W2049358079 @default.
- W2093732800 cites W2059017712 @default.
- W2093732800 cites W2064165635 @default.
- W2093732800 cites W2066413879 @default.
- W2093732800 cites W2070807361 @default.
- W2093732800 cites W2086943348 @default.
- W2093732800 cites W2096910509 @default.
- W2093732800 cites W2112014972 @default.
- W2093732800 cites W2118638423 @default.
- W2093732800 cites W2126605118 @default.
- W2093732800 cites W2128016314 @default.
- W2093732800 cites W2135189827 @default.
- W2093732800 cites W2138442302 @default.
- W2093732800 cites W2148953262 @default.
- W2093732800 cites W2153056550 @default.
- W2093732800 cites W2155819889 @default.
- W2093732800 cites W2160845673 @default.
- W2093732800 cites W2163404991 @default.
- W2093732800 cites W43675158 @default.
- W2093732800 doi "https://doi.org/10.1016/j.stemcr.2013.10.005" @default.
- W2093732800 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3841249" @default.
- W2093732800 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24286026" @default.
- W2093732800 hasPublicationYear "2013" @default.
- W2093732800 type Work @default.
- W2093732800 sameAs 2093732800 @default.
- W2093732800 citedByCount "120" @default.
- W2093732800 countsByYear W20937328002014 @default.
- W2093732800 countsByYear W20937328002015 @default.
- W2093732800 countsByYear W20937328002016 @default.
- W2093732800 countsByYear W20937328002017 @default.
- W2093732800 countsByYear W20937328002018 @default.
- W2093732800 countsByYear W20937328002019 @default.
- W2093732800 countsByYear W20937328002020 @default.
- W2093732800 countsByYear W20937328002021 @default.
- W2093732800 countsByYear W20937328002022 @default.
- W2093732800 countsByYear W20937328002023 @default.
- W2093732800 crossrefType "journal-article" @default.
- W2093732800 hasAuthorship W2093732800A5001644376 @default.
- W2093732800 hasAuthorship W2093732800A5008270331 @default.
- W2093732800 hasAuthorship W2093732800A5026456188 @default.
- W2093732800 hasAuthorship W2093732800A5031360571 @default.
- W2093732800 hasAuthorship W2093732800A5039803307 @default.
- W2093732800 hasAuthorship W2093732800A5052730567 @default.
- W2093732800 hasAuthorship W2093732800A5062422399 @default.
- W2093732800 hasAuthorship W2093732800A5069996996 @default.
- W2093732800 hasAuthorship W2093732800A5083420672 @default.
- W2093732800 hasAuthorship W2093732800A5085891063 @default.
- W2093732800 hasAuthorship W2093732800A5089685702 @default.
- W2093732800 hasAuthorship W2093732800A5090913554 @default.
- W2093732800 hasBestOaLocation W20937328001 @default.
- W2093732800 hasConcept C104317684 @default.
- W2093732800 hasConcept C144024400 @default.
- W2093732800 hasConcept C145103041 @default.
- W2093732800 hasConcept C149923435 @default.
- W2093732800 hasConcept C153911025 @default.
- W2093732800 hasConcept C28328180 @default.
- W2093732800 hasConcept C2908647359 @default.
- W2093732800 hasConcept C49105822 @default.
- W2093732800 hasConcept C502942594 @default.
- W2093732800 hasConcept C54355233 @default.
- W2093732800 hasConcept C81089528 @default.
- W2093732800 hasConcept C8185291 @default.
- W2093732800 hasConcept C81885089 @default.
- W2093732800 hasConcept C86803240 @default.
- W2093732800 hasConcept C95444343 @default.