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• W2093734210 abstract "Single calcium-channel currents were recorded from membrane patches of cultured beta-cells dissociated from human islets of Langerhans. In the absence of exogenous glucose, low frequency spontaneous calcium-channel openings of small amplitude (-0.34 +/- 0.02 pA at 0 mV pipet potential) were observed in all membrane patches examined (25 mM Ca2+ in the patch pipet). The frequency of channel openings was rather insensitive to the membrane potential across the patch (range from ca 0 to 60 mV pipet potential; chord conductance 4.9 +/- 0.2 pS). Addition of glucose induced a dose-dependent increase in the frequency of openings of the Ca2(+)-channel (from now on referred to as the CaG-channel). A few minutes after the addition of glucose (greater than or equal to 11 mM), bursts of action potentials were often observed which were elicited only if Ca2+ was present in the solution bathing the beta-cells. Application of glucose in the presence of mannoheptulose (11 mM), a blocker of the hexokinase controlling the first stage of glycolysis, had no effect and the activity of the CaG-channel remained at its resting level. The readily permeant mitochondrial substrate 2-keto-isocaproate (KIC, 10 mM) was as effective as glucose in eliciting action potentials from cells forming part of cell aggregates. The activity of the CaG-channel was significantly increased by KIC (11 mM). Although spike and Ca2(+)-channel activity were markedly stimulated by glucose or KIC in all cells examined, regular bursts of action potentials were seen only if the patch was formed on beta-cells which were part of a cell aggregate. Mannoheptulose (11 mM) prevented the activation of the CaG-channel by glucose (11 mM) but not by KIC (11 mM). Once activated, the CaG-channel remained active even after excision of the patch. We propose that the physiological control of this Ca2(+)-channel is mediated by one or more products of glucose metabolism." @default.
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• W2093734210 date "1990-02-26" @default.
• W2093734210 modified "2023-10-14" @default.
• W2093734210 title "A new class of calcium channels activated by glucose in human pancreatic β-cells" @default.
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• W2093734210 doi "https://doi.org/10.1016/0014-5793(90)80568-4" @default.
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