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- W2093735344 endingPage "182" @default.
- W2093735344 startingPage "171" @default.
- W2093735344 abstract "In the lifetime of an individual, every single gene will have undergone mutation on about 10(10) separate occasions. Nevertheless, cancer occurs mainly with advancing age. Here, we hypothesize that the evolutionary pressure driving the creation of the T cell receptor (TCR) repertoire was primarily the homeostatic surveillance of the genome. The subtly variable T cells may in fact constitute an evolutionary link between the invariable innate and hypervariable B cell systems. The new model is based on the homeostatic role of T cells, suggesting that molecular complementarity between the positively selected TCR and the self peptide-presenting major histocompatibility complex molecules establishes and regulates homeostasis, strictly limiting variations of its components. Notwithstanding, the 'homeostatic role of T cells' model offers a more realistic explanation as to how a naïve clonal immune system can cope with the much faster replicating pathogens, despite a limited repertoire that is capable of facing only a small fraction of the vast antigenic universe at a time." @default.
- W2093735344 created "2016-06-24" @default.
- W2093735344 creator A5025649527 @default.
- W2093735344 creator A5038949664 @default.
- W2093735344 creator A5039037754 @default.
- W2093735344 creator A5040702576 @default.
- W2093735344 creator A5058546981 @default.
- W2093735344 creator A5071748657 @default.
- W2093735344 date "2007-01-01" @default.
- W2093735344 modified "2023-10-11" @default.
- W2093735344 title "T Cells Survey the Stability of the Self: A Testable Hypothesis on the Homeostatic Role of TCR-MHC Interactions" @default.
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