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- W2093739965 abstract "To evaluate the outcome and prognostic factors in Chinese children undergoing matched unrelated donor hematopoietic stem cell transplantation (UDT). Retrospective analysis of clinical data of 53 consecutive children received URT between November 2002 to December 2007 in our center was performed. Conditioning regimen for Acute lymphoblastic leukemia (ALL) was total body irradiation based, aplastic anemia (AA) was fludarabine based. The other patients received busulphan based myeloablative regimen. The median age was 8.4 years (range, 1.5∼21) with the median follow up 36 months (range, 18∼80). The probability of 3-year overall survival (OS) was 71.5%. Treatment related mortality (TRM) was 19.0%. 9.4% died after post-transplant leukemia relapse. Incidence of Grade I-II and III-IV acute and chronic GVHD was 63%, 29% and 46%. There was significant difference of OS for patients older or younger than 10 years(50.0% vs 84.8%, p=0.003)and patients with different underlying diseases (ALL, AML, CML and non-malignant disease: 36.4%, 80.0%, 61.5% and 100%, p=0.001). There was also significant difference of OS for patients with low-risk, high-risk leukemia (83.3% vs 42.9%, p=0.013) and patient received HLA 0-1 locus 2-3 loci high resolution mismatched transplant (83.3% vs 53.3%, p=0.034). But there was no significant difference of OS among the patient received peripheral stem cell, bone marrow or cord blood transplant (70.3%,87.5%,62.5%, p=0.542) and patients with 0-II and III-IV acute GVHD (77.8% vs 60.0%, p=0.140). The important prognostic factors for OS after UDT were the degree of HLA match, the age of patient and the type of underlying disease. Patients less than 10 year with non-malignant disease receiving 0-1 locus high resolution mismatched UDT had the best outcome. Myeloid, low-risk leukemia was superior to other leukemia." @default.
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- W2093739965 date "2010-02-01" @default.
- W2093739965 modified "2023-10-16" @default.
- W2093739965 title "Outcome Of Chinese Children With Unrelated Donor Hematopoietic Stem Cell Transplantation: A Single Center Experience" @default.
- W2093739965 doi "https://doi.org/10.1016/j.bbmt.2009.12.416" @default.
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