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- W2093741667 abstract "Gastric cancer is a leading cause of cancer death worldwide, and significant effort has been focused on clarifying the pathology of gastric cancer. In particular, the development of genome-wide analysis tools has enabled the detection of genetic and epigenetic alterations in gastric cancer; for example, aberrant DNA methylation in gene promoter regions is thought to play a crucial role in gastric carcinogenesis. The etiological viewpoint is also essential for the study of gastric cancers, and two distinct pathogens, Helicobacter pylori (H. pylori) and Epstein-Barr virus (EBV), are known to participate in gastric carcinogenesis. Chronic inflammation of the gastric epithelium due to H. pylori infection induces aberrant polyclonal methylation that may lead to an increased risk of gastric cancer. In addition, EBV infection is known to cause extensive methylation, and EBV-positive gastric cancers display a high methylation epigenotype, in which aberrant methylation extends to not only Polycomb repressive complex (PRC)-target genes in embryonic stem cells but also non-PRC-target genes. Here, we review aberrant DNA methylation in gastric cancer and the association between methylation and infection with H. pylori and EBV." @default.
- W2093741667 created "2016-06-24" @default.
- W2093741667 creator A5000685038 @default.
- W2093741667 creator A5005708651 @default.
- W2093741667 creator A5077422132 @default.
- W2093741667 creator A5081519082 @default.
- W2093741667 date "2014-01-01" @default.
- W2093741667 modified "2023-10-01" @default.
- W2093741667 title "DNA methylation in gastric cancer, related to<i>Helicobacter pylori</i>and Epstein-Barr virus" @default.
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