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• W2093744380 abstract "Burkholderia cepacia and Pseudomonas aeruginosa are opportunistic pathogens that commonly cause pulmonary infections in cystic fibrosis patients and occasionally co-infect patients' lungs. Both organisms possess quorum-sensing systems dependent on N-acyl homoserine lactone (N-acyl-HSL). Cross-feeding assays demonstrated that P. aeruginosa and B. cepacia were able to utilize heterologous N-acyl-HSL signaling molecules. The ability of quorum-sensing genes from one species to complement the respective quorum-sensing mutations in the heterologous species was also examined. These studies suggest that B. cepacia CepR can use N-acyl-HSLs synthesized by RhlI and LasI and that P. aeruginosa LasR and RhlR can use N-acyl-HSLs synthesized by CepI. It is possible that a mixed bacterial population of B. cepacia and P. aeruginosa can coordinately regulate some of their virulence factors and influence the progression of lung disease due to infection with these organisms." @default.
• W2093744380 created "2016-06-24" @default.
• W2093744380 creator A5002999179 @default.
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• W2093744380 date "2002-08-01" @default.
• W2093744380 modified "2023-10-18" @default.
• W2093744380 title "Interspecies communication between<i>Burkholderia cepacia</i>and<i>Pseudomonas aeruginosa</i>" @default.
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• W2093744380 doi "https://doi.org/10.1139/w02-068" @default.
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