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- W2093744693 abstract "BackgroundThe number of patients with a previously treated tumor, needing cardiac surgery is increasing. Whether this operation in these patients is justified is determined by the long-term outcome.MethodsOf 8620 patients referred for cardiac surgery, 205 had a documented malignant tumor. The time interval between the occurrence of the tumor and the cardiac surgery was recorded. These patients were matched with 205 patients without a tumor according to age, gender, comorbidity and type of cardiac surgery. The patients were followed retrospectively. A χ2 Kaplan Meier and Cox' regression analysis were performed.ResultsDuring follow-up, 95.8% of the patients were traced (2794 patient years). Univariate analysis showed that 5- and 10-year survival was better in patients without a malignant tumor in the history (0.91 ± 0.02 versus 0.72 ± 0.03 and 0.73 ± 0.04 versus 0.40 ± 0.05; p < 0.0001). For shorter time intervals, mortality for all causes and mortality due to the tumor increase significantly (p < 0.0001). Multivariate analysis identified 4 independent variables: a malignant tumor in the history (p < 0.001), chronic obstructive pulmonary disease (p = 0.003), age (p = 0.001), and impaired left ventricular function (p = 0.035)ConclusionsA malignant tumor in the history is the most prognostic factor after cardiac surgery, but the operation is still rewarding. Fatal progression of the tumor is seen if the time interval between the occurrence of the malignant tumor and cardiac surgery is short. Other unfavorable factors are decreased left ventricular function, chronic obstructive pulmonary disease and high age." @default.
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- W2093744693 date "2004-05-01" @default.
- W2093744693 modified "2023-10-16" @default.
- W2093744693 title "Effect of prior malignancy on survival after cardiac surgery" @default.
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- W2093744693 doi "https://doi.org/10.1016/j.athoracsur.2003.08.049" @default.
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