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- W2093745889 abstract "The effects of glucocorticoids on lipopolysaccharide (LPS)-stimulated lymphocytes undergoing proliferation and differentiation were studied using cells from a corticosensitive species, the mouse, and a relatively corticoresistant species, the guinea pig. A B-cell-specific mitogen, LPS, caused a 5-fold increase in [3H]thymidine ([3H]TdR) incorporation in murine splenic lymphocytes compared to that in nonmitogen-stimulated cells. Increasing concentrations of various glucocorticoids decreased [3H]TdR incorporation. The order of biological effectiveness of the glucocorticoids was triamcinolone acetonide > dexamethasone > cortisol = corticosterone > estradiol. Triamcinolone acetonide (TA) caused decreases in [3H]TdR incorporation ranging from 24% at 10-13 M to 75% at 10-5 M. Neither cortexolone nor progesterone alone affected [3H]TdR incorporation in LPS-stimulated murine cells, but these antiglucocorticoids at a 1000-fold excess blocked the inhibitory effect of TA on [3H]TdR incorporation. Nonmitogen-stimulat..." @default.
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- W2093745889 title "The Effect of Glucocorticoids on Mitogen-Stimulated B-Lymphocytes: Thymidine Incorporation and Antibody Secretion*" @default.
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- W2093745889 doi "https://doi.org/10.1210/endo-110-1-169" @default.
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