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• W2093746997 abstract "Aims Oxidative stress is an early event in the cascade leading in neuronal damage after hypoxic–ischemic (HI) brain injury. In the present study, we examined the dose response and window of opportunity for neuroprotection after HI injury with Allene Oxide Synthase (AOS), an anti-oxidative enzyme of the member of cytochrome P450 family. Methods Adult male rats received intra-cerebro-ventricular infusions of either saline (vehicle) or AOS (1 μg or 10 μg or 100 μg per rat, intracerebroventricular n = 16 all groups) either 45 min or 3 h after unilateral HI brain injury. Brains were collected 5 days later. The extent of brain damage, neuronal survival, apoptosis, and glial reactions were assessed in the striatum, hippocampus, and cortex. Results Allene Oxide Synthase was associated with reduced neuronal damage scores when given 45 min, but not 3 h, after HI injury (P < 0.0001) in all brain regions. AOS treatment (10 μg) improved neuronal survival in the striatum, cortex, and hippocampus (P < 0.05, P < 0.001) and reduced the microglia reaction (P < 0.05) and numbers of caspase-3-positive cells in the hippocampus (P < 0.01). Conclusions Early blockade of oxidative stress after HI injury reduces inflammatory response, neuronal necrosis, and apoptosis. The neuroprotective effects of AOS were time of administration-dependent suggesting a relatively restricted window of opportunity for acute brain injury." @default.
• W2093746997 created "2016-06-24" @default.
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• W2093746997 date "2012-09-24" @default.
• W2093746997 modified "2023-09-27" @default.
• W2093746997 title "Window of Opportunity for Neuroprotection with an Antioxidant, Allene Oxide Synthase, after Hypoxia-Ischemia in Adult Male Rats" @default.
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• W2093746997 doi "https://doi.org/10.1111/cns.12004" @default.
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