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• W2093755764 endingPage "e0122114" @default.
• W2093755764 startingPage "e0122114" @default.
• W2093755764 abstract "Diffusion tensor imaging (DTI) has been suggested as a new promising tool in MS that may provide greater pathological specificity than conventional MRI, helping, therefore, to elucidate disease pathogenesis and monitor therapeutic efficacy. However, the pathological substrates that underpin alterations in brain tissue diffusivity are not yet fully delineated. Tract-specific DTI analysis has previously been proposed in an attempt to alleviate this problem. Here, we extended this approach by segmenting a single tract into areas bound by seemingly similar pathological processes, which may better delineate the potential association between DTI metrics and underlying tissue damage.Several compartments were segmented in optic radiation (OR) of 50 relapsing-remitting MS patients including T2 lesions, proximal and distal parts of fibers transected by lesion and fibers with no discernable pathology throughout the entire length of the OR.Asymmetry analysis between lesional and non-lesional fibers demonstrated a marked increase in Radial Diffusivity (RD), which was topographically limited to focal T2 lesions and potentially relates to the lesional myelin loss. A relative elevation of Axial Diffusivity (AD) in the distal part of the lesional fibers was observed in a distribution consistent with Wallerian degeneration, while diffusivity in the proximal portion of transected axons remained normal. A moderate, but significant elevation of RD in OR non-lesional fibers was strongly associated with the global (but not local) T2 lesion burden and is probably related to microscopic demyelination undetected by conventional MRI.This study highlights the utility of the compartmentalization approach in elucidating the pathological substrates of diffusivity and demonstrates the presence of tissue-specific patterns of altered diffusivity in MS, providing further evidence that DTI is a sensitive marker of tissue damage in both lesions and NAWM. Our results suggest that, at least within the OR, parallel and perpendicular diffusivities are affected by tissue restructuring related to distinct pathological processes." @default.
• W2093755764 created "2016-06-24" @default.
• W2093755764 creator A5020921178 @default.
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• W2093755764 date "2015-03-25" @default.
• W2093755764 modified "2023-10-07" @default.
• W2093755764 title "Decoding Diffusivity in Multiple Sclerosis: Analysis of Optic Radiation Lesional and Non-Lesional White Matter" @default.
• W2093755764 cites W1493533123 @default.
• W2093755764 cites W1634780921 @default.
• W2093755764 cites W1965400726 @default.
• W2093755764 cites W1969226019 @default.
• W2093755764 cites W1975244640 @default.
• W2093755764 cites W1975518016 @default.
• W2093755764 cites W1976243808 @default.
• W2093755764 cites W1976692470 @default.
• W2093755764 cites W1977719765 @default.
• W2093755764 cites W1979525053 @default.
• W2093755764 cites W1979976762 @default.
• W2093755764 cites W1981111637 @default.
• W2093755764 cites W1981453697 @default.
• W2093755764 cites W1984698416 @default.
• W2093755764 cites W1988586000 @default.
• W2093755764 cites W1991492504 @default.
• W2093755764 cites W1994275622 @default.
• W2093755764 cites W1994743387 @default.
• W2093755764 cites W1994972002 @default.
• W2093755764 cites W1998929321 @default.
• W2093755764 cites W2002914256 @default.
• W2093755764 cites W2006178657 @default.
• W2093755764 cites W2011931872 @default.
• W2093755764 cites W2013495374 @default.
• W2093755764 cites W2013644613 @default.
• W2093755764 cites W2015842377 @default.
• W2093755764 cites W2019074756 @default.
• W2093755764 cites W2021658407 @default.
• W2093755764 cites W2023807439 @default.
• W2093755764 cites W2025047388 @default.
• W2093755764 cites W2028266147 @default.
• W2093755764 cites W2047977577 @default.
• W2093755764 cites W2048870844 @default.
• W2093755764 cites W2049874375 @default.
• W2093755764 cites W2051698918 @default.
• W2093755764 cites W2055406505 @default.
• W2093755764 cites W2057434762 @default.
• W2093755764 cites W2057860462 @default.
• W2093755764 cites W2059177186 @default.
• W2093755764 cites W2063001897 @default.
• W2093755764 cites W2064262911 @default.
• W2093755764 cites W2065200510 @default.
• W2093755764 cites W2065404009 @default.
• W2093755764 cites W2066429484 @default.
• W2093755764 cites W2070468319 @default.
• W2093755764 cites W2072682344 @default.
• W2093755764 cites W2074633222 @default.
• W2093755764 cites W2077176232 @default.
• W2093755764 cites W2077876133 @default.
• W2093755764 cites W2080113649 @default.
• W2093755764 cites W2080423736 @default.
• W2093755764 cites W2080748802 @default.
• W2093755764 cites W2084669193 @default.
• W2093755764 cites W2085813310 @default.
• W2093755764 cites W2092631976 @default.
• W2093755764 cites W2094008621 @default.
• W2093755764 cites W2094894028 @default.
• W2093755764 cites W2099114955 @default.
• W2093755764 cites W2102531734 @default.
• W2093755764 cites W2104140249 @default.
• W2093755764 cites W2106736831 @default.
• W2093755764 cites W2110080262 @default.
• W2093755764 cites W2110645708 @default.
• W2093755764 cites W2111306572 @default.
• W2093755764 cites W2119790076 @default.
• W2093755764 cites W2122545833 @default.
• W2093755764 cites W2131307089 @default.
• W2093755764 cites W2136568934 @default.
• W2093755764 cites W2141805326 @default.
• W2093755764 cites W2142255966 @default.
• W2093755764 cites W2142577589 @default.
• W2093755764 cites W2144665769 @default.
• W2093755764 cites W2147927529 @default.
• W2093755764 cites W2148333046 @default.
• W2093755764 cites W2157723935 @default.
• W2093755764 cites W2160215963 @default.
• W2093755764 cites W2161281218 @default.
• W2093755764 cites W2162723250 @default.
• W2093755764 cites W2165804706 @default.
• W2093755764 cites W2170480020 @default.
• W2093755764 cites W2320853752 @default.
• W2093755764 cites W2325038063 @default.

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