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• W2093759970 abstract "(+/-)-3alpha-hydroxy homoepibatidine 4 has been synthesized from the alkaloid scopolamine 5 and its properties as a nicotinic agonist assessed. While still binding strongly, the compound showed reduced agonist potency for the alpha(4)beta(2) nAChR compared with the parent compound epibatidine 1. Compound 4 also displayed generally similar binding and selectivity profiles at alpha(4)beta(2), alpha(2)beta(4), alpha(3)beta(4), and alpha(4)beta(4) nAChR subtypes to those for nicotine." @default.
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• W2093759970 date "2004-01-01" @default.
• W2093759970 modified "2023-09-25" @default.
• W2093759970 title "Synthesis and nicotinic receptor activity of a hydroxylated tropane" @default.
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• W2093759970 doi "https://doi.org/10.1016/j.bmcl.2003.09.081" @default.
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