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• W2093760093 startingPage "83" @default.
• W2093760093 abstract "The multifaceted action of thrombospondin-1 (TSP-1) depends on its ability to physically interact with different ligands, including structural components of the extracellular matrix, other matricellular proteins, cell receptors, growth factors, cytokines and proteases. Through this network, TSP-1 regulates the ligand activity, availability and structure, ultimately tuning the cell response to environmental stimuli in a context-dependent manner, contributing to physiological and pathological processes. Complete mapping of the TSP-1 interactome is needed to understand its diverse functions and to lay the basis for the rational design of TSP-1-based therapeutic approaches. So far, large-scale approaches to identify TSP-1 ligands have been rarely used, but many interactions have been identified in small-scale studies in defined biological systems. This review, based on information from protein interaction databases and the literature, illustrates current knowledge of the TSP-1 interactome map." @default.
• W2093760093 created "2016-06-24" @default.
• W2093760093 creator A5003180276 @default.
• W2093760093 creator A5018599202 @default.
• W2093760093 creator A5047175478 @default.
• W2093760093 creator A5072467454 @default.
• W2093760093 date "2014-07-01" @default.
• W2093760093 modified "2023-10-10" @default.
• W2093760093 title "Current understanding of the thrombospondin-1 interactome" @default.
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