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• W2093760864 abstract "Results are summarized that were obtained when analyzing mitochondrial membranes by means of electron microscopy using a variety of preparatory methods. One characteristic feature of all these methods is that they have been developed as an alternative to conventional preparatory procedures used in electron microscopy with the purpose of minimizing structural modifications caused by denaturation of membrane proteins and by extraction of membrane lipids. All these methods give basically the same result, with the structure of the mitochondrial membranes drastically deviating from that observed in conventionally prepared material. Furthermore they make it possible to distinguish structurally between three different types of membranes in the mitochondrion, while all three membranes appear identical in material prepared according to conventional techniques. The methods used in these studies were exposed to critical examination with the aim of finding some factor common to all of them that could have caused the same artifactual distortion of the membrane structure. No such common factor could be found, and no mechanism involving expansion or aggregation that could have produced these different structures of the membranes as artifactual modifications could be identified. On this basis it was concluded that the observed structure of the mitochondrial membranes in material prepared with these methods was closer to the native structure than that observed in material prepared according to conventional methods. As a consequence the observations were interpreted in terms of the molecular structure of the membranes. This interpretation led to the formulation of a new concept regarding the structure of metabolically active membranes. The interior of the inner mitochondrial membranes was considered to consist of a nonaqueous, mixed polar and nonpolar phase. The mitochondrion would thus consist of a two-phase system with alternating aqueous and nonaqueous phases. The advantages of a nonaqueous mixed polar and nonpolar environment for the functioning of complex multienzyme systems are discussed. Some criticism raised against some earlier work on this project is answered, and the relationship between the concept proposed here and the Singer-Nicolson [Singer, S. J., and Nicolson, G. L. (1972) Science 175, 720] membrane model is discussed in detail." @default.
• W2093760864 created "2016-06-24" @default.
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• W2093760864 date "1978-09-01" @default.
• W2093760864 modified "2023-10-18" @default.
• W2093760864 title "The structure of mitochondrial membranes: A new concept" @default.
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• W2093760864 doi "https://doi.org/10.1016/s0022-5320(78)90033-3" @default.
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