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- W2093761750 endingPage "11944" @default.
- W2093761750 startingPage "11937" @default.
- W2093761750 abstract "Fibroblast growth factor 1 (FGF-1, also known as acidic FGF) is a mitogen for a variety of mesoderm- and neuroectoderm-derived cells, as well as an angiogenic factor in vivo. It has been implicated in angiogenic diseases including atherosclerosis, cancer and inflammatory diseases. In the present study, the entire transcriptional unit of the mouse FGF-1 gene, including four promoters, is characterized. By nucleotide sequence and RNase protection analyses, we have determined that its 3′-end resides 3.2 kilobase pairs downstream from the stop codon. We have previously cloned and characterized the mouse homologue of the human 1B promoter, as well as a novel upstream untranslated exon. In order to elucidate the regulatory mechanism of FGF-1 gene expression, the mouse promoter containing TATA and CAAT consensus sequences (FGF-1.A) was isolated from a P1 library and characterized. We further determined that the mouse heart is the most abundant source for the FGF-1.A mRNA. Finally, via both RNase protection analysis and 5′-rapid amplification of cDNA ends, we determined the transcription start site of the FGF-1.A mRNA." @default.
- W2093761750 created "2016-06-24" @default.
- W2093761750 creator A5007416325 @default.
- W2093761750 creator A5057857888 @default.
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- W2093761750 date "1999-04-01" @default.
- W2093761750 modified "2023-10-16" @default.
- W2093761750 title "Characterization of the Entire Transcription Unit of the Mouse Fibroblast Growth Factor 1 (FGF-1) Gene" @default.
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- W2093761750 doi "https://doi.org/10.1074/jbc.274.17.11937" @default.
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