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• W2093770277 abstract "I n this issue of Translational Research, Askari et al 1 provide the results of a double-blinded, randomized, clinical trial for the treatment of primary biliary cirrhosis (PBC) with tetrathiomolybdate (TM). A total of 28 patients were randomized to either ursodeoxycholic acid (UDCA) and TM or to UDCA and placebo, and these patients were followed for a median of 14 months. PBC is a chronic cholestatic liver disease that predominantly involves middle-aged women; it is characterized by portal inflammation and loss of the epithelial cells in the small and middle-sized bile ducts, which occur at different rates and with varying degrees of severity in different patients. If untreated, PBC is a slowly progressive disease that causes substantial loss of intrahepatic bile ducts and ultimately results in advanced fibrosis, cirrhosis, and liver failure. As such," @default.
• W2093770277 created "2016-06-24" @default.
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• W2093770277 date "2010-03-01" @default.
• W2093770277 modified "2023-09-28" @default.
• W2093770277 title "Is there a role for tetrathiomolybdate in the treatment of primary biliary cirrhosis?" @default.
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• W2093770277 doi "https://doi.org/10.1016/j.trsl.2009.10.006" @default.
• W2093770277 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20171596" @default.
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