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- W2093774373 abstract "The spermatogonial stem cells of 101/H mice have been found to be more sensitive to killing by acute X-ray doses than those of the “standard” C3H/HeH × 101/H F1 hybrid. Duration of the sterile period was longer throughout the 0.5–8.0-Gy dose range tested and “recovered” testis weights, taken after recovery of fertility, were more severely reduced. The shapes of the sterile period dose-response curves were similar, but with the 101/H mice the plateau occured at 3–5 Gy, rather than at 6 Gy. An equivalent observation was made with the testis weight data. The translocation dose-response curve was bell-shaped, as previously found with the hybrid, but yields were lower at all but the lowest doses. Notably, peak yields occured at 3–5 Gy, rather than at 6 Gy. The altered stem cell killing and genetic responses may be explained either by a higher proportion of radiosensitive cells in the heterogeneous stem cell population or by a higher ratio of cell killing to recoverable chromosome damage which might imply a reduced repair capacity. The latter finds some support in other data. The pattern of genetic response obtained when an X-ray dose was given in two fractions at various intervals was similar in 101/H and the hybrid mice, suggesting that their kinetics of stem cell repopulation following depletion differ little." @default.
- W2093774373 created "2016-06-24" @default.
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- W2093774373 date "1987-01-01" @default.
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- W2093774373 title "Enhanced spermatogonial stem cell killing and reduced translocation yield from X-irradiated 101/H mice" @default.
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- W2093774373 doi "https://doi.org/10.1016/0027-5107(87)90254-5" @default.
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