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• W2093776083 abstract "Invasive fungal infections in preterm neonates in the neonatal intensive care unit are predominantly caused by <i>Candida</i> spp<i>,</i> and have a high burden of morbidity and mortality. Effective prophylactic strategies have recently become available, but the identification of the best possible strategies to manage high-risk infants is still a priority. Choice and use of appropriate antifungal drugs needs careful assessment of neonatal characteristics, the epidemiology and drug pharmacokinetics. Ideally, antifungal drugs for preterm neonates should target fungal bio-films, prevent or effectively treat end-organ localisations, be active against fluconazole-resistant Candida species, and have reliable safety and tolerability profiles. The paper reviews the state-of-the-art in the area of neonatal fungal infections, and addresses some open questions related to the best possible prophylactic and therapeutic strategies to be implemented in such unique patients." @default.
• W2093776083 created "2016-06-24" @default.
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• W2093776083 date "2015-01-20" @default.
• W2093776083 modified "2023-09-23" @default.
• W2093776083 title "Update on the management of<i>Candida</i>infections in preterm neonates" @default.
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• W2093776083 doi "https://doi.org/10.1136/archdischild-2012-303350" @default.
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