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- W2093784805 abstract "Antidepressant drugs with different mechanism of action are known to have distinct influences on pituitary hormone secretion. Antidepressants which primarily act via noradrenaline (NA) reuptake inhibition (e.g. desipramine) stimulate growth hormone (GH) secretion, whereas serotonin (5 HT) reuptake inhibiting antidepressants (e.g. clomipramine, indalpine) are characterized by prolactin (PRL) stimulation. Cortisol (COR) secretion can be increased both by noradrenergic and serotonergic agonists. In this investigation the effects of acute po-administration of 4 mg reboxetine on the growth hormone (GH) and prolactin (PRL) secretion were examined in twelve physically and mentally healthy subjects, compared to placebo. Reboxetine is a new antidepressant which displays a selective noradrenaline reuptake inhibition. After insertion of an intravenous catheter, blood samples were drawn one hour prior to the administration of reboxetine or placebo, at time of application, and during the time of five hours after application in periods of 30 minutes. Plasma concentrations of GH, and PRL were determined in each blood sample. The AUC (AUC = area under the curve) value was used as parameter for the GH, and PRL response. In comparison to placebo, reboxetine caused a significant stimulation of GH secretion (p < 0.05). The GH stimulatory effects of reboxetine are probably mediated via noradrenergic a2-receptors. Unexpectedly, reboxetine significantly enhanced PRL secretion as well (p < 0.05). Since PRL secretion is known to be stimulated via serotonergic mechanisms and reboxetine is proven to be highly selective for noradrenaline reuptake inhibition, further studies have to be performed to clarify this result. Furthermore, a significant increase of the mean arterial blood pressure and the pulse rata could be demonstrated after application of 4 mg reboxetine 0, < 0.05)." @default.
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- W2093784805 date "2000-01-01" @default.
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- W2093784805 title "The influence of reboxetine on GH and PRL secretion in healthy subjects" @default.
- W2093784805 doi "https://doi.org/10.1016/s0306-4530(00)90180-x" @default.
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