FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2093796103> ?p ?o ?g. }

• W2093796103 endingPage "2107" @default.
• W2093796103 startingPage "2098" @default.
• W2093796103 abstract "To investigate the effects of thyroxine (T4) administration on bone mass, five 81-day-old female rats were treated with T4 (25 μg of T4/100 g of body weight [bw]/day), and bone mineral density (BMD) was measured by dual-energy X-ray absorptiometry (DXA) 28 days later. The BMD values for the total skeleton, femoral, and tibial subsegments were lower than in controls (p ≤ 0.05). The lumbar spine (L2–L5) was not significantly affected by T4 treatment. Next, thirty-seven 211 ± 1.5 (mean ± SEM)-day-old female rats were divided into six groups as follows: (1) control; (2) ovariectomized (OVX); (3) 1xT4 (∼1.0 μg of T4/100 g of bw/day; approximately physiological replacement dose); (4) OVX+1xT4; (5) 2xT4 (∼2.0 μg of T4/100 g of bw/day); (6) OVX+2xT4. DXA scans were performed at days 0 and 85. Control rats showed a generalized BMD increase, as opposed to a decrease in OVX rats. The trabecular bone volume of the fifth lumbar vertebra was also lower in OVX rats than in controls (p < 0.05). The 1xT4 treatment had no effect on BMD of intact rats, while treatment with 2xT4 impaired the expected BMD increase. Unexpectedly, the OVX+1xT4 group presented a generalized BMD increase that was significant for the total skeleton, L2–L5, and femoral subsegments (p < 0.05), comparable to controls. Treating OVX animals with 2xT4 did not potentiate the osteopenic effects of estrogen deficiency, nor did it reverse the osteopenic effects of OVX. In conclusion, treatment with high doses of T4 caused BMD to decrease substantially, particularly at the femur, whereas near physiological doses of T4 prevented bone loss associated with OVX, and regardless of bone type (trabecular or cortical), the skeleton site seems to be a more important determinant of the effects of thyroid hormone on bone mass." @default.
• W2093796103 created "2016-06-24" @default.
• W2093796103 creator A5026395401 @default.
• W2093796103 creator A5032326208 @default.
• W2093796103 creator A5036205270 @default.
• W2093796103 date "1997-12-01" @default.
• W2093796103 modified "2023-09-23" @default.
• W2093796103 title "Effects of Thyroid Hormone Administration and Estrogen Deficiency on Bone Mass of Female Rats" @default.
• W2093796103 cites W1967061310 @default.
• W2093796103 cites W1967833277 @default.
• W2093796103 cites W1979525194 @default.
• W2093796103 cites W1984225489 @default.
• W2093796103 cites W1992032967 @default.
• W2093796103 cites W1994353252 @default.
• W2093796103 cites W1994846791 @default.
• W2093796103 cites W1996148662 @default.
• W2093796103 cites W1999003511 @default.
• W2093796103 cites W2007940807 @default.
• W2093796103 cites W2008596143 @default.
• W2093796103 cites W2013559444 @default.
• W2093796103 cites W2018096397 @default.
• W2093796103 cites W2020432522 @default.
• W2093796103 cites W2021189716 @default.
• W2093796103 cites W2023426997 @default.
• W2093796103 cites W2030324928 @default.
• W2093796103 cites W2032937559 @default.
• W2093796103 cites W2034716124 @default.
• W2093796103 cites W2037128775 @default.
• W2093796103 cites W2042813663 @default.
• W2093796103 cites W2043089512 @default.
• W2093796103 cites W2043774208 @default.
• W2093796103 cites W2045690940 @default.
• W2093796103 cites W2047312094 @default.
• W2093796103 cites W2048828599 @default.
• W2093796103 cites W2051022943 @default.
• W2093796103 cites W2055397537 @default.
• W2093796103 cites W2056360570 @default.
• W2093796103 cites W2056889736 @default.
• W2093796103 cites W2057814467 @default.
• W2093796103 cites W2059725412 @default.
• W2093796103 cites W2060236587 @default.
• W2093796103 cites W2064077191 @default.
• W2093796103 cites W2070939672 @default.
• W2093796103 cites W2078161465 @default.
• W2093796103 cites W2079587265 @default.
• W2093796103 cites W2080741216 @default.
• W2093796103 cites W2081802470 @default.
• W2093796103 cites W2083552955 @default.
• W2093796103 cites W2092156129 @default.
• W2093796103 cites W2097551860 @default.
• W2093796103 cites W2112897084 @default.
• W2093796103 cites W2136393430 @default.
• W2093796103 cites W2150513416 @default.
• W2093796103 cites W2150756587 @default.
• W2093796103 cites W2499719795 @default.
• W2093796103 cites W4327852300 @default.
• W2093796103 doi "https://doi.org/10.1359/jbmr.1997.12.12.2098" @default.
• W2093796103 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9421243" @default.
• W2093796103 hasPublicationYear "1997" @default.
• W2093796103 type Work @default.
• W2093796103 sameAs 2093796103 @default.
• W2093796103 citedByCount "68" @default.
• W2093796103 countsByYear W20937961032012 @default.
• W2093796103 countsByYear W20937961032013 @default.
• W2093796103 countsByYear W20937961032014 @default.
• W2093796103 countsByYear W20937961032015 @default.
• W2093796103 countsByYear W20937961032016 @default.
• W2093796103 countsByYear W20937961032017 @default.
• W2093796103 countsByYear W20937961032019 @default.
• W2093796103 countsByYear W20937961032020 @default.
• W2093796103 countsByYear W20937961032021 @default.
• W2093796103 countsByYear W20937961032023 @default.
• W2093796103 crossrefType "journal-article" @default.
• W2093796103 hasAuthorship W2093796103A5026395401 @default.
• W2093796103 hasAuthorship W2093796103A5032326208 @default.
• W2093796103 hasAuthorship W2093796103A5036205270 @default.
• W2093796103 hasConcept C105702510 @default.
• W2093796103 hasConcept C126322002 @default.
• W2093796103 hasConcept C134018914 @default.
• W2093796103 hasConcept C141071460 @default.
• W2093796103 hasConcept C18969341 @default.
• W2093796103 hasConcept C2776541429 @default.
• W2093796103 hasConcept C2776886416 @default.
• W2093796103 hasConcept C2777164284 @default.
• W2093796103 hasConcept C2779329777 @default.
• W2093796103 hasConcept C2779835254 @default.
• W2093796103 hasConcept C2781440623 @default.
• W2093796103 hasConcept C44575665 @default.
• W2093796103 hasConcept C71924100 @default.
• W2093796103 hasConcept C8264082 @default.
• W2093796103 hasConceptScore W2093796103C105702510 @default.
• W2093796103 hasConceptScore W2093796103C126322002 @default.
• W2093796103 hasConceptScore W2093796103C134018914 @default.
• W2093796103 hasConceptScore W2093796103C141071460 @default.
• W2093796103 hasConceptScore W2093796103C18969341 @default.
• W2093796103 hasConceptScore W2093796103C2776541429 @default.
• W2093796103 hasConceptScore W2093796103C2776886416 @default.
• W2093796103 hasConceptScore W2093796103C2777164284 @default.

• next